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Pharmacogenetics of antidepressants / Alessandro Serretti.
- Format:
- Video
- Author/Creator:
- Serretti, Alessandro, author.
- Language:
- English
- Subjects (All):
- Pharmacogenetics.
- Precision medicine.
- Physical Description:
- 1 streaming video file (51 min.) : color, sound
- Place of Publication:
- London : Henry Stewart Talks Ltd, 2024.
- System Details:
- video file
- Contents:
- Introduction
- Antidepressants (and all >100 psych drugs)
- Variability
- Clinical-demographic predictors of response
- Sociodemographic predictors
- Clinical predictors
- Precision medicine
- Pharmacogenetics (PGx)
- PGx in clinical guidelines
- PGx biomarkers in drug labels (FDA)
- Psychotropic drugs
- Antidepressant efficacy & plasma levels: correlation
- Practicalities: when to recommend PGx testing?
- Pharmacodynamics?
- 5-HTTLPR variants explained 7% of the variance of antidepressant efficacy
- 5-HTTLPR effects
- Genome-Wide Association Studies (GWAS)
- Polygenic risk scores
- GWAS studies
- GWAS TRD summary
- What evidence supports a role of genetics in treatment outcomes?
- Whole exome sequencing
- Role of the identified top GO gene sets
- Predictive model validity
- Other factors that can modulate the clinical picture
- Personalized antidepressant treatments
- Polygenic risk scores (PRS) in psychiatry
- Potential use of PRS for predicting treatment response in MDD
- TRD in the UKB primary care EHRs
- Non-response in MDD patients according to SCZ PRS quantiles
- Using PRS to treat other disorders
- Non-pharmacological treatments for depression
- Drug repositioning for TRD
- A prediction algorithm?
- Combining psychotherapy and pharmacotherapy
- Available pharmacogenetic tests
- Genetic algorithms to predict antidepressant response and side effects
- Is pharmacogenetic testing ready for a store near you?
- Criticism to the commercially available pharmacogenetics
- Misleading guidance from pharmacogenomic testing
- Precision psychiatry in clinical practice
- Precision psychiatry in clinical practice: the future
- How to utilize clinical and genetic information for personalized treatment of MDD
- Portable real-time biological analyses
- Perspective
- Conclusion
- Speaker details.
- Notes:
- Description based on publisher supplied metadata and other sources.
- Retrieved August 14, 2025, from https://doi.org/10.69645/CVAA8322.
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