Chemistry and Biology of O-GlcNAcylation / edited by Wen Yi.

Format:

Book

Contributor:

Yi, Wen, editor.

Language:

English

Subjects (All):

Medicine--Research.

Medicine.

Biology--Research.

Biology.

Cytology.

Biomedical Research.

Cell Biology.

Local Subjects:

Biomedical Research.

Cell Biology.

Physical Description:

1 online resource (178 pages)

Edition:

1st ed. 2024.

Place of Publication:

Singapore : Springer Nature Singapore : Imprint: Springer, 2024.

Summary:

O-linked N-acetylglucosamine (O-GlcNAc) is a prevalent post-translational modification of numerous intracellular proteins. This modification has recently emerged as a key regulator of various important biological processes, including gene transcription, stress response, metabolic homeostasis, and immune regulation. Given the critical role of O-GlcNAc in normal physiology, increasing evidence has now demonstrated that deregulation of O-GlcNAc is closely associated with the development and progression of various diseases, including neurodegeneration, cardiovascular disease, and cancer. This book provides a comprehensive overview of the current progress and understanding of this modification in biology, and likely provides new research directions in the future.

Contents:

Chapter 1. Chemical tools for decoding the functions of O-GlcNAcylation

Chapter 2. Profiling O-GlcNAcylation with mass spectrometry

Chapter 3. O-GlcNAcylation and cell metabolism

Chapter 4. O-GlcNAcylation and transcriptional regulation and epigenetics

Chapter 5. O-GlcNAcylation and signal transduction

Chapter 6. O-GlcNAcylation and stem cells

Chapter 7. O-GlcNAcylation and immune regulation

Chapter 8. O-GlcNAcylation and neuronal development, neurodegeneration and neurological disorders.

Notes:

Includes bibliographical references.

ISBN:

981-9748-64-X