Immune system ageing : immunesenescence / Janet M. Lord.

Format:

Video

Author/Creator:

Lord, Janet M., author.

Language:

English

Subjects (All):

Age factors in disease.

Immunity, Innate.

Physical Description:

1 streaming video file (44 min., 07 sec.) : color, sound

Other Title:

Immune system ageing

Place of Publication:

London : Henry Stewart Talks Ltd, 2024.

System Details:

video file

Contents:

Retrieved August 14, 2025, from https://doi.org/10.69645/BSAU5922.

Introduction

Content of the talk

The role of the immune system: criteria for immune ageing

Older individuals are more susceptible to infection and have higher morbidity and mortality

SARS-CoV-2 infection: age and sex differences amongst hospitalised patients

COVID-19 severity: age and sex differences amongst hospitalised patients

COVID-19 mortality: age and sex differences amongst hospitalised patients

Reduced vaccination efficacy with age

Existing immune memory fades

Cancer incidence increases with age

Autoimmunity increases with age

The age-related increase in systemic inflammation: inflammageing

Causes of inflammaging

Cells of the immune system

Impact of Advancing Age on Innate Immunity

NK cell subtypes

CD56DIM NK cell cytotoxicity

NK cytotoxicity decreases with age

Mechanism of functional decline

NK cell number and function in COVID-19

Senescent cells upregulate NKG2D ligands

Senescent cells also express HLA-E evading killing by CD8 and NK cells

Ageing and neutrophils

Typical migratory pathway - young subjects

Typical migratory pathway - older subjects

The decline is age-related

Increased serum NE activity in healthy elders

Compromised chemotaxis is a leukocyte-wide phenomenon

Effect of age on phagocytosis

Reduced NET generation with age

Age, superoxide and NET generation

Bacterial infections and age

Key functions of monocytes and dendritic cells

Effect of age on monocyte and DC phenotype

Monocytes/macrophages are basally active but compromised when challenged

Impact of Advancing Age on Adaptive Immunity

Cells of the adaptive immune system

Memory:naïve T cell ratio increases with age

Thymic output reduces with age due to fat infiltration

Telomere erosion in CD8+ T cells with age

T cell senescent-like phenotype in older adults

IMM-AGE: an integrated score for immune ageing

Hallmarks of T cell ageing

Inducing senescence in CD4 T cells accelerates ageing in other body systems

Effect of age on B cells

Correcting immunesenescence

Boosting T cell autophagy improves T cell responses

Improving T cell function and vaccination responses: Rapamycin

Old mice are more susceptible to coronavirus infection but senolytics improve survival

Statins improve neutrophil migration in vitro

Simvastatin to modify Neutrophil functiOn in Older patients with PneumonIa (SNOOPI)

Summary.

Notes:

Description based on publisher supplied metadata and other sources.