Blood Oxidant Ties : the Evolving Concepts in Myocardial Injury and Cardiovascular Disease / Bashir Matata, Maqsood Elahi, and Priscilla Day-Walsh, editors.

Format:

Book

Author/Creator:

Matata, Bashir, Author.

Contributor:

Matata, Bashir, editor.

Elahi, Maqsood, editor.

Day-Walsh, Priscilla, editor.

Language:

English

Subjects (All):

Oxidative stress--Physiological effect.

Oxidative stress.

Lipids--Metabolism.

Lipids.

Cardiovascular system--Diseases.

Cardiovascular system.

Antioxidants.

Physical Description:

1 online resource (185 pages)

Edition:

First edition.

Place of Publication:

Singapore : Bentham Science Publishers Pte. Ltd., [2023]

Summary:

Blood Oxidant Ties: The Evolving Concepts in Myocardial Injury and Cardiovascular Diseaseis an update on the recent advances in the development of antioxidant-based therapies. It starts with an overview of the mechanisms underlying the genesis of oxidative stress, summarizing the link between oxidative stress and a number of cardiovascular conditions. This is followed by an explanation of how oxidative stress interacts with lipid metabolism and the placental environment. Three chapters on the role of antioxidant-based therapy for cardiovascular diseases round up the book. Key Features- Outlines several cell-signaling pathways that are modulated by the interplay between reducing and oxidizing agents (redox status) and gene expression in the cardiovascular disease process- Brings information about maternal programming environment in the placenta- Covers development of novel nanotechnology-based antioxidant delivery systems for effective drug delivery- Includes references for further reading The book is aimed at a broad readership of scientific and medical professionals involved in research on cardiovascular diseases, pathophysiology, pharmacy, pharmaceutical science and life sciences. It also serves as a reference for scholars who want to understand the complex biochemical mechanisms of antioxidant agents.

Contents:

Cover

Title

Copyright

End User License Agreement

Contents

Foreword

Preface

List of Contributors

Redox Signaling, Oxidative Stress in Cardiovascular Disease -basic Science and Clinical Aspects

Bashir M. Matata1,* and Maqsood M. Elahi2

INTRODUCTION

Reactive Oxygen Species and Reactive Nitrogen Species

Nitric Oxide Synthases and the Generation of Reactive Nitrogen Species

Potential Sources of Reactive Oxygen Species (ROS)

Enzymatic Generation of NADPH Oxidase as a Source of ROS

The Mechanisms of Assembly and Activation of NOX Enzymes

The Biological Effect of NOX-activation

Defects in the NOX System and its Consequences

Intracellular Reactive Oxidant Species as By-products of Mitochondrial Respiration

Generation of Reactive Oxidant Species by the Xanthine Oxidoreductase System

NOS Uncoupling as a Source of Reactive Oxidant Species in the Cell

Redox Signalling Pathways

ROS Signalling as the Mechanism for NF-κB Activation

ROS Signalling via Ap-1 Activation

ROS Signalling via Peroxisome Proliferators Activated Receptors (PPAR)

CONCLUDING REMARKS

LIST OF ABBREVIATIONS

ACKNOWLEDGEMENT

REFERENCES

Oxidative Stress and Leukocytes Activation - The Two Keystones of Ischemia/Reperfusion Injury during Myocardial Infarction, Valve Disease, and Atrial Fibrillation

Oxidative Stress as a Putative Mechanism for Atherogenesis and Myocardial Injury

Interaction Between Circulating Leukocytes, ROS and the Antioxidant Systems

Hypertension

Aortic Valve Disease

Atrial Fibrillation

Atherosclerosis and Premature Coronary Artery Disease (CAD)

Diabetes

Stroke

Heart Failure

The Role of Antioxidants

CONCLUSION

REFERENCES.

Lipids, Oxidation, and Cardiovascular Disease

Priscilla Day-Walsh1,*

PATHWAYS INVOLVED IN CHOLESTEROL METABOLISM AND TRANSPORT

Chylomicrons

Chylomicron Remnants

Very Low-Density Lipoproteins

Intermediate Density Lipoproteins (IDL)

Low-Density Lipoproteins (LDL)

Lipoprotein(a) (Lp(a))

High-Density Lipoproteins (HDL)

FFA Metabolism Through Mitochondrial Beta-oxidation

Lipoproteins and Lipid Oxidation

Enzymatic Lipid Oxidation

Regulation of Cholesterol Synthesis and Metabolism

Reverse Cholesterol Transport and Cholesterol Metabolism to Bile Acids

CLINICAL TRIALS TARGETING CHOLESTROL METABOLISM

Maternal Factors and the Placenta: A Programming Environment for Cardiovascular Disease

Wai Lok Whitney Ching1, Priscilla Day-Walsh2 and Amanda Sferruzzi-Perri1,*

The Maternal Environment and Programming of Cardiovascular Disease

The Placenta, Fetal Outcomes, and CVD Programming

Oxidative Stress and Lipid Oxidation

The Influence of the Maternal Microbiome on Developmental Programming

Genetic and Epigenetic Regulation in Fetal Programming and CVD

Single Nucleotide Polymorphisms

MicroRNAs

Epigenetics: DNA Methylation and Histone Modifications

The Emerging Role of Microbiome in Cardiovascular Diseases

Emad Shehata1,2 and Priscilla Day-Walsh1,*

Microbiome Characteristics in Health and Disease

Associations of Microbiota and CVD

Short Chain Fatty Acids in Cardiovascular Disease

Regulation of Cholesterol and Bile Acids by the Gut Microbiota in CVD

Metabolism to Coprostanol and Incorporation into Bacterial Membranes

Impact of Bile Acid Metabolising Bacteria on PH and Amino Acid Sparing.

Interaction of Secondary Bile Acids With Host Receptors

Choline, L-carnitine, and Their Gut Derived Metabolite Trimethylamine Oxide [TMAO]

Associations With Other Gut Metabolites

The Use of Prebiotics and Probiotics to Alter the Microbiome and Prevent CVD

Oxidants and Antioxidants Interplay in the Modulation of Inflammation and Cardiovascular Disease

Bashir Matata1,* and Maqsood Elahi2

Oxidative Stress as a Putative Mechanism for CVD

Molecular Effects of Oxidative Stress

Oxidative Stress and Programmed Cell Death

Oxidative Stress and Myocardial Ischaemia-Reperfusion (I/R) Injury

Antioxidants as a Defence System Against Inflammation and Cardiovascular Disease

Other Naturally Occurring Antioxidants

Prevention of Reperfusion Injury in Acute Myocardial Infarction: A "flashback" Journey of Novel Strategies Based on the Potential Therapeutic Role of Antioxidants

Francisco Salazar-Cornejo1, Abraham Gajardo2,3, Marcelo J. Kogan4, 5 and Ramón Rodrigo3,*

PATHOPHYSIOLOGY OF MYOCARDIAL ISCHEMIA-REPERFUSION INJURY

Sources of Reactive Oxygen and Nitrogen Species in the Heart

Cardiac Effects of Ischemia and Reperfusion

ANTIOXIDANTS AS THERAPEUTIC AGENTS

Ascorbate

N-acetylcysteine

Deferoxamine

Ginger

Alpha-linolenic Acid

Nootkatone

Inonotus obliquus

Memantine

Dexmedetomidine

INTEGRATIVE FOCUS SUPPORTING THE EFFICACY OF A COMBINED ANTIOXIDANT TREATMENT

Improvement of Nitric Oxide Availability in Myocardial Ischemia/reperfusion: Role of Nanotechnology as a Therapeutic Approach.

Marcelo J Kogan1,2,*, Francisco Salazar-Cornejo3, Abraham Gajardo4,5 and Ramón Rodrigo5,*

Oxidative/nitrosative Stress in Myocardial Ischemia/reperfusion: Potential Pharmacological Targets

THERAPEUTIC FAILURE IN OXIDATIVE STRESS

DRUG DELIVERY SYSTEM BY NANOPARTICLES

Targeting strategies

NANOPARTICLES AND OXIDATIVE STRESS CONTROL IN ISCHEMIA/REPERFUSION

NITRIC OXIDE DONOR IN CARDIOVASCULAR DISEASE AND NANOPARTICLE APPROACH

ACKNOWLEDGEMENTS

Subject Index

Back Cover.

Notes:

Description based on publisher supplied metadata and other sources.

Description based on print version record.

Includes bibliographical references and index.

ISBN:

9789815165012

9815165011

OCLC:

1394120455