Metabolomics of Bladder Cancer : An Emerging Application / Vishwajeet Singh and Mukul Kumar Singh, editors.

Format:

Book

Contributor:

Singh, Vishwajeet, editor.

Singh, Mukul Kumar, editor.

Language:

English

Subjects (All):

Biochemical markers.

Bladder--Cancer.

Bladder.

Metabolites.

Physical Description:

1 online resource (158 pages)

Edition:

First edition.

Place of Publication:

London, England : Stacy Masucci, [2025]

Summary:

Metabolomics of Bladder Cancer: An Emerging Application offers insights into the latest research methodologies and potential therapeutic applications.The book examines how applied research on the discovery of metabolomic biomarkers with prognostic and predictive value is needed to stratify patients into different risk groups, minimizing.

Contents:

Front Cover

Metabolomics of Bladder Cancer

Metabolomics of Bladder Cancer An Emerging Application

Copyright

Contents

Contributors

1 - Contribution of metabolomics in the discovery of biomarker for urinary bladder cancer

Introduction

Metabolomics techniques

LC MS-based metabolomic analysis of human bladder cancer

Selectivity and sensitivity

Sample preparation

Data analysis

Example

Multivariate statistical analysis

NMR-based metabolomics analysis of human bladder cancer

Sample preparations

Multivariate pattern recognition and statistical analysis

Conclusion

References

2 - Role of tobacco on bladder cancer pathways

Tobacco

Tobacco products and bladder cancer

Tobacco smoking

Second hand smoke

Smokeless tobacco

Carcinogenic components of tobacco

Polycyclic aromatic hydrocarbons

Nitrosamines

Aldehydes

Others

Bladder cancer pathways

Tobacco smoke and aberrant methylation

Tobacco smoke causes DNA damage and adducts

Nitrosomine-induced bladder cancer

Tobacco smoke causes epithelial-mesenchymal transition

JNK pathway

Ras pathway

PI3K-AKT/mTOR pathway

Wnt/β-catenin signaling pathway

p53 and cell cycle

Chemoresistance

Smoking cessation

Concluding remark and future challenges

Abbreviations

3 - Regulation of glycolysis in bladder cancer

Role of different glycolytic pathway genes and enzymes in the progression of urinary bladder cancer

Different strategies to control the regulation of glycolysis in urinary bladder cancer

A key point of regulation in urinary bladder cancer metabolism is pkm2

PKM2 citrullination controls glycolysis and the growth of cancer cells in UBC.

Through the coactivation of hypoxia-inducible factor 1α, steroid receptor coactivator-3 controls glucose metabolism in blad ...

Through the PTEN/PI3K/AKT/mTOR axis, a lentiviral sponge for miRNA-21 reduces aerobic glycolysis in bladder cancer

Effects of Licochalcone A on the regulation of glycolysis in urinary bladder cancer

Regulation of glycolysis by the long noncoding RNAs in urinary bladder cancer

Regulation of glycolysis in bladder cancer by the knockdown of YBX1 factor

Regulation of glycolysis via managing the expression of lysine deacetylase Sirtuin 1 in urinary bladder cancer

In bladder cancer, orphan retinoic acid-related receptor C controls glycolysis through the pd-l1/itgb6/stat3 signaling axis

Targeting various enzymes of glycolytic pathways with the inhibitors for the regulation of glycolysis in bladder cancer

Through LDHA-dependent glycolysis reprogramming, CDKN3 reverses cisplatin resistance in bladder cancer

Melatonin reduces the growth of bladder tumors by inhibiting PPAR/ENO1-mediated glycolysis

4 - Metabolism of fatty acid

Metabolomics and biomarkers

Fatty acids

Fatty acids synthesis and oxidation

Fatty acid oxidation/β-oxidation

Pathways impacted by altered lipid metabolism in bladder cancer

Fatty acid-based biomarkers for bladder cancer

Implications for clinical management

Future paths and significance of fatty acid metabolomics

Early and accurate diagnosis

Personalized treatment strategies

Therapeutic monitoring and response assessment

Identification of novel drug targets

Understanding disease progression and prognosis

Facilitating research and clinical trials

Long-term implications for public health

Preventive interventions

Population health surveillance

Precision public health.

Early detection and screening programs

Data-driven policy making

Research and development

Health education and awareness

5 - Regulation of pentose phosphate pathway in bladder cancer

Altered metabolism in malignant transformed cells

Changes in glucose metabolism

Crosslinks of glucose metabolism with pentose phosphate pathway

Modifications in pentose phosphate pathway

G6PDH

6PGDH

RPI and RPE

TALDO and TKT

p53

Myc

HIF-α

The involvement of PPP in urothelial carcinoma cell survival

Future implications: Application in treatment therapy

6 - Mitochondrial metabolism

Mitochondria: The cellular powerhouses

Structure and function of mitochondria

Mitochondrial metabolism beyond energy production

Carbohydrate metabolism

Fatty acid metabolism

Amino acid metabolism

Mitochondria in cellular processes

Mitochondrial DNA (mtDNA) and genetic variation

Metabolic reprogramming in bladder cancer: Shifting the balance between glycolysis and oxidative phosphorylation

Glycolysis versus oxidative phosphorylation

Mitochondrial metabolic pathways in cancer

Warburg effect in bladder cancer

Mitochondrial metabolism in bladder cancer: Insights into altered dynamics, tumor progression, and energy balance

Altered mitochondrial dynamics in cancer cells

Impact of mitochondrial dysfunction on tumor progression

The role of mitochondria in tumor energy balance

Molecular mechanisms of mitochondrial dysfunction in bladder cancer

Reactive oxygen species and oxidative stress

Genetic and epigenetic factors

Mitochondrial DNA mutations

Cell proliferation and cell death

Therapeutic targeting of mitochondrial metabolism in bladder cancer

Targeting mitochondrial respiration.

Inhibiting complex I

Targeting complex II

Mitochondrial uncouplers

Modulating mitochondrial dynamics

Targeting Drp1

Promoting fusion

Revitalizing mitochondria-driven apoptosis: Mitochondria-targeted therapies

Challenges and future directions in targeting mitochondrial metabolism in bladder cancer

Overcoming therapeutic challenges

Ethical considerations

Emerging technologies and research frontiers

Conclusion: The promise of mitochondrial metabolism targeting in bladder cancer

7 - Metabolic effect of cancer therapy

Cancer metabolism

Impact of cancer therapy on metabolism

Impact of chemotherapy on metabolism

Metabolic consequences of radiation therapy

Immunotherapy and metabolic remodeling

Metabolic reprogramming in cancer

Metabolism as a therapeutic target

Targeting metabolic vulnerabilities

Combination therapies

Metabolic challenges and opportunities in cancer therapy

Metabolic heterogeneity and resistance

Metabolic side effects and toxicities

Metabolic imaging in cancer therapy

Personalized cancer treatment based on metabolism

Future directions

8 - Metabolomics and racial disparities in bladder cancer carcinogenesis

Urothelial carcinoma of bladder: Two distinct entities

Racial disparities on cancer incidence, risk factors, and survival

Metabolomics: A new perspective

Metabolomics in carcinogenesis

Integrating racial disparities

Metabolomic disparities in various racial and ethnic groups

Challenges associated with bladder cancer management

Research to clinical implications

Recent developments/Future implications

Multiomics: A bigger and a better picture

Index

A

B

C

D

E

F

G

H

I

J

L

M

N

O

P

R

S

T.

U

W

Y

Back Cover.

Notes:

Includes bibliographical references and index.

Description based on publisher supplied metadata and other sources.

Description based on print version record.

ISBN:

9780443238826

0443238820

OCLC:

1455753506