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The Evolution of Immunotherapy Against Tumors : An Historical Approach / Domenico Ribatti.
- Format:
- Book
- Author/Creator:
- Ribatti, Domenico, 1956- author.
- Language:
- English
- Subjects (All):
- Immunotherapy.
- Physical Description:
- 1 online resource (194 pages)
- Edition:
- First edition.
- Place of Publication:
- London, England : Academic Press, [2025]
- Summary:
- The Evolution of Immunotherapy Against Tumors: An Historical Approach summarizes the literature concerning the development of the theory of immune surveillance against tumors.It discusses the evidence for and against this theory, along with the concept of immunoediting.
- Contents:
- Front Cover
- The Evolution of Immunotherapy Against Tumors
- The Evolution of Immunotherapy Against Tumors: An Historical Approach
- Copyright
- Contents
- Preface
- 1 - Historical background
- The primordia
- Jenner and the vaccinology
- Metchnikoff and the discovery of macrophages
- Ehrlich and the side-chain theory of antibody formation
- The natural selection hypothesis and the clonal selection theory
- The discovery of the structure of antibodies
- Diversity of antibody specificities
- The discovery of the primary immune organs
- Immunodeficiencies
- B cells, T cells, and other effector cells of the immune response
- The major histocompatibility complex and immunological tolerance
- Immunotherapy
- 2 - First evidence
- 3 - Bacillus Calmette-Guerin
- 4 - Immunosurveillance against tumors
- Evidence confirming the theory of immunosurveillance
- Evidence against the theory of immunosurveillance
- 5 - Immunoediting
- 6 - Inflammation and tumors
- Tumor hypoxia
- Tumor vasculature
- Tumor angiogenesis
- Alternative mode of tumor vascularization
- Genomic instability of tumor endothelial cells and increase of metastatic potential
- Inhibition of angiogenesis
- Tumor-associated macrophages
- Tie-2 expressing monocytes
- B lymphocytes
- T lymphocytes
- T regulatory cells
- Natural killer cells
- Tumor associated neutrophils
- Mast cells
- Cancer associated fibroblasts
- Dendritic cells
- Myeloid-derived suppressor cells
- 7 - Therapeutic implications
- 8 - Cytokine therapies
- Basic immunotherapy with IL-2
- Interferons
- 9 - Adoptive T cell therapy
- 10 - Tumors express specific antigens
- 11 - Monoclonal antibodies
- Tyrosine kinase inhibitors
- Bispecific monoclonal antibodies
- Side effects
- 12 - Immunosuppressive effects of VEGF.
- 13 - Immunomodulatory effects of angiopoietin, platelet derived growth factor, and hepatocyte growth factor
- Immunomodulatory effect of angiopoietins and of platelet derived growth factor
- Immunomodulatory effect of hepatocyte growth factor
- 14 - Oncolytic virus therapy
- 15 - Cancer vaccines
- 16 - Engineering of T cells and CAR-T therapy
- 17 - Immune checkpoint inhibitors
- 18 - Co-applying anti-angiogenic and immune checkpoint inhibitors
- 19 - Combination therapies
- 20 - Conclusions
- References
- Index
- Back Cover.
- Notes:
- Includes bibliographical references and index.
- Description based on publisher supplied metadata and other sources.
- Description based on print version record.
- ISBN:
- 9780443217999
- 0443217998
- OCLC:
- 1455130930
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