Cytokine Storm Syndrome / edited by Randy Q. Cron, Edward M. Behrens.

Format:

Book

Contributor:

Cron, Randy Q., editor.

Behrens, Edward M., editor.

Series:

Advances in Experimental Medicine and Biology, 2214-8019 ; 1448

Language:

English

Subjects (All):

Immunology.

Molecular genetics.

Diseases.

Cytokines.

Molecular Genetics.

Cytokines and Growth Factors.

Local Subjects:

Immunology.

Molecular Genetics.

Diseases.

Cytokines and Growth Factors.

Physical Description:

1 online resource (609 pages)

Edition:

2nd ed. 2024.

Place of Publication:

Cham : Springer International Publishing : Imprint: Springer, 2024.

Summary:

Cytokine Storm Syndromes, including HLH and MAS, are frequently fatal disorders, particularly if not recognized early and treated during presentation. The genetics of Cytokine Storm Syndromes are being defined with many of the risk alleles giving rise to mutations in the perforin-mediated cytolytic pathway used by CD8 cytotoxic T cells and natural killer cells. These are being studied using murine models. Up to 10% of the general population may carry risk alleles for developing Cytokine Storm Syndromes, and Cytokine Storm Syndromes are being increasingly recognized around the world in pediatric and adult hospitals. A variety of infectious, rheumatic, and oncologic triggers are commonly associated with Cytokine Storm Syndromes, but understanding this disorder is critical for all researchers and physicians to ensure timely and appropriate therapy. This second edition addresses all aspects of the disorder, from genetics, pathophysiology, and ongoing research, to clinical presentations, risk factors and treatment. New-to-this-edition features include dedicated chapters on severe COVID-19 CSS, and post-COVID CSS of multi-system inflammatory syndrome in children (MIS-C). In addition, novel topics including CSS associated with Castleman disease, pregnancy, therapeutics, transplantation, and cardiac bypass, as well as treatment with JAK inhibitors are addressed. .

Contents:

1. Cytokines in cytokine storm syndromes

2. History of HLH

3. The history of macrophage activation syndrome in autoimmune diseases

4. Clinical features of cytokine storm syndromes

5. Laboratory features and pathology of cytokine storm syndromes

6. Criteria for cytokine storm syndromes

7. Familial HLH genetics

8. Secondary HLH genetics

9. Genetics of macrophage activation syndrome in systemic juvenile idiopathic arthritis

10. CD8+ T cell biology in cytokine storm syndromes

11. Immunology of cytokine storm syndromes: Natural killer cells

12. Myeloid cells in the immunopathogenesis of cytokine storm syndrome

13. Cytokine storm

14. Primary immunodeficiencies

15. Infectious triggers of cytokine storm syndromes: Herpes virus family (non-EBV)

16. CSS associated with Epstein Barr Virus

17. Hemorrhagic Fever and other viruses

18. Cytokine storm syndrome as a manifestation of primary HIV infection

19. Bacteria-associated cytokine storm syndrome

20. Zoonoticbacterial infections triggering cytokine storm syndrome

21. Parasitic and fungal triggers

22. COVID-19 pneumonia and cytokine storm syndrome

23. Cytokine storm associated with Systemic Juvenile Idiopathic Arthritis

24. Systemic lupus erythematosus

25. Kawasaki disease

26. The intersections of autoinflammation and cytokine storm

27. Other rheumatic triggers

28. Multisystem Inflammatory Syndrome in children

29. Hemophagocytic lymphohistiocytosis in the context of hematological malignancies and solid tumors

30. Cytokine storm and sepsis-induced Multiple Organ Dysfunction Syndrome

31. The cytokine storm of Multicentric Castleman Disease

32. Cytokine storm syndromes associated with pregnancy and therapeutics

33. fHLH models

34. sHLH models

35. Etoposide therapy of CSS

36. IL-1 family blockade

37. IL-6 blockade

38. IFNy blockade

39. JAK inhibitors

40. Other immunomodulatory HLH treatments

41. Salvage therapy for HLH.

Notes:

Includes bibliographical references and index.

ISBN:

3-031-59815-6