Microglia : Physiology, Pathophysiology and Therapeutic Potential / edited by Marie-Ève Tremblay, Alexei Verkhratsky.

Format:

Book

Author/Creator:

Tremblay, Marie-Eve.

Contributor:

Verkhratskiĭ, A. N. (Alekseĭ Nestorovich)

Series:

Advances in Neurobiology, 2190-5223 ; 37

Language:

English

Subjects (All):

Neurosciences.

Neurology.

Immunology.

Neuroscience.

Local Subjects:

Neuroscience.

Neurology.

Immunology.

Physical Description:

1 online resource (635 pages)

Edition:

1st ed. 2024.

Place of Publication:

Cham : Springer International Publishing : Imprint: Springer, 2024.

Summary:

The past decade has witnessed a revolution in our understanding of microglia, especially since their roles in the healthy CNS have started to unravel. These cells were shown to actively maintain health, in concert with neurons and other types of CNS cells, providing further insight into their crucial involvement with diseases. Edited by Drs. Marie-Ève Tremblay and Alexei Verkhratsky, Microglia: Physiology, Pathophysiology and Therapeutic Potential shares with the scientific and medical community the latest discoveries in the microglial research field, with a truly comprehensive collection of chapters written by the top specialists across five continents. The book begins by explaining briefly what they are, from both historical and evolutionary points of view, and how they can be studied. The first section explains their physiological roles in the maturation, function, and plasticity of the CNS. The second section focuses on their general involvement in neuropathophysiology, and the third section on their critical implication in specific CNS diseases, including neurotrauma, neuropathic pain, ischemia and stroke, infectious diseases, autoimmune diseases, neurodevelopmental and neuropsychiatric disorders, substance use and addiction, sleep disorders, ageing, and neurodegenerative diseases. The fourth section presents their clinical potential as a targeted therapeutic tool for these CNS diseases.

Contents:

PART I: Introduction

Chapter 1: General Pathophysiology of Microglia

Chapter 2: History of Microglia

Chapter 3: Evolution of Microglia

Chapter 4: Visualization, Fate Mapping, Ablation and Mutagenesis of Microglia in the Mouse Brain

Chapter 5: Technological Innovations: Progress of the Structural and Functional in vivo Imaging of Microglia

PART II: Basic Discoveries in Physiology

Chapter 6:Microglial Physiology: Receptors

Chapter 7: Microglial Physiology: Calcium Signalling

Chapter 8:Contactomics of Microglia and Intercellular Communication

Chapter 9: Elimination of Neurones: Embryonic and Postnatal Development

Chapter 10: Developmental Angiogenesis, Astrogliogenesis, and Myelination

Chapter 11: Synaptic Formation and Elimination

Chapter 12: Synaptic Maturation, Activity, and Plasticity

Chapter 13: Adult Neurogenesis, Learning and Memory

Chapter 14: Regulation of Sleep and Wakefulness

PART III: General Pathophysiology of Microglia

Chapter 15: Roles in Innate Immunity

Chapter 16: Microglia and Systemic Immunity

Chapter 17: Microglia and Microbiome-Gut-Brain Axis

Chapter 18: Stress and Microglia: A Double-Edged Relationship

Chapter 19: Substance Use and Addiction

Chapter 20: Microglia and Sleep Disorders

Chapter 21: Ageing

Part IV: Microglia and Pathophysiology of Diseases of Nervous System

Chapter 22: Neuropathic Pain

Chapter 23: Role of Microglia in Stroke

Chapter 24: Infectious Diseases including COVID-19 and HAND

Chapter 25: Microglia and Multiple Sclerosis

Chapter 26: Neurodevelopmental and Neuropsychiatric Disorders

Chapter 27: Neurodegenerative Diseases

Chapter 28: Microglia in Glioma

PART V: Clinical Potential

Chapter 29: Microglial Risk Alleles for Neurodegenerative Diseases (GWAS studies)

Chapter 30: Emerging Models for the Study of Human Microglia in vitro (e.g. IPSCs, minibrains)

Chapter 31: Emerging Models for the Study of Human Microglia ex vivo (comparison between human and rodent microglia)

Chapter 32: Radiotracers for Microglial PET Imaging in vivo (focus on TSPO and its limitations)

Chapter 33: Role of Microglial Modulation in Therapies for Perinatal Brain Injuries Leading to Neurodevelopmental Disorders

Chapter 34: Metabolic Control of Microglial Function

Chapter 35: Microglial Emerging Therapies and Targets under Clinical Trial

Chapter 36: Epilogue.

Notes:

Description based on publisher supplied metadata and other sources.

ISBN:

3-031-55529-5

OCLC:

1453755781