Advances in Antifungal Drug Development : Natural Products with Antifungal Potential / edited by Nikhat Manzoor.

Format:

Book

Contributor:

Manzoor, Nikhat, editor.

Language:

English

Subjects (All):

Pharmacology.

Medical microbiology.

Fungi.

Mycology.

Microbiology.

Medical Microbiology.

Local Subjects:

Pharmacology.

Fungi.

Medical Microbiology.

Physical Description:

1 online resource (723 pages)

Edition:

1st ed. 2024.

Place of Publication:

Singapore : Springer Nature Singapore : Imprint: Springer, 2024.

Summary:

This book explores the antifungal properties of natural products and reviews their antifungal mechanism. An introductory chapter illustrates the various fungal pathogenic species, common fungal diseases, and general mechanisms of action of various antifungal classes, including natural products. The book comprises seven sections and each section contains chapters on the efficacy and antifungal mode of action of plant extracts, essential oils, natural compounds, their derivatives, and plant-based nanoparticles. A section summarizes the antifungal efficacy of compounds derived from sources other than plants, like microbes. Besides compound toxicity, the book explores the antifungal mode of action and efficacy against the virulence and pathogenicity of fungal pathogens like Candida, Aspergillus, Cryptococcus, Histoplasma, and other pathogenic fungi. Further, the book also describes recent advancements in the discovery of novel drug targets and therapeutic strategies that are non-toxic and more efficacious for combating drug resistance. This book is an invaluable source for researchers working in the field of fungal biochemistry, anti-microbial, and anti-bacterial and undergraduate and postgraduate students of microbiology and pharmacology.

Contents:

Part I: Introduction

An Update on Human Fungal Diseases: A Holistic Overview

Part II: Plant Extracts and Essential Oils as antifungals

Composition of different species of Lamiaceae plant family: A potential bio-source of terpenoids and antifungal agents

Plant Essential Oils and their Active Ingredients

Essential Oils and Their Compounds for Applications in Fungal Diseases: Conventional and Non-conventional Approaches

Antifungal efficacy of plant essential oils against Candida, Aspergillus and Cryptococcus species

Unveiling the Potential of Essential Oils as Antifungal Agents Against Non-albicans Candida Species: Mechanisms of Action and Therapeutic Implications

Part III: Plant derived natural compounds as antifungals

Molecules of natural origin as inhibitors of signal transduction pathway in Candida albicans

Harnessing the antifungal potential of natural products

Clinical Significance, Molecular Formation, and Natural Antibiofilm Agents of Candida albicans

Futuristic Avenues in Candida Treatment: Exploiting Plant Derived agents as potent inhibitors of Candidiasis

Antifungal efficacy of Terpenes and mechanism of action against human pathogenic fungi

Part IV: Plant based nanoparticles as antifungals

Exploration of new plant-based nanoparticles with potential antifungal activity and their mode of action

Green-synthesized nanoparticles: Characterization and Antifungal mechanism of action

Green-synthesized nanoparticles: Antifungal efficacy and other applications

Metal nanoparticles: management and control of phytopathogenic fungi

Phytosynthesized Nanoparticles: Antifungal activity and mode of action

Antifungal Efficacy of Plant-based Nanoparticles as a putative tool for antifungal therapy

Part V: Plant based chemical derivatives as antifungals

Antifungal Efficacy of Natural Product-Based Chemical Derivatives

Therapeutic potential of phytochemicals and their derivatives as antifungal candidates: Recent discovery and development

Bioactive Heterocyclic Analogs as Antifungal Agents: Recent Advances and Future Aspects

Part VI: Natural products derived from microbes and other natural sources

Bioactive potential of Streptomyces spp. against diverse pathogenic fungi

Antifungal potential of bioactive compounds derived from microbes and other natural sources: Challenges and future scope

Microbial and plant natural products and their antifungal targets

Part VII: Toxicology of natural antifungals and other applications

Toxicology of antifungal and antiviral drugs

Natural Compounds Toxicity: An Egregiously Overlooked Topic

Fungal infestation of biodegradable heritage material: application of conservatory treatments and characterization of the article

Antifungals Discovery and Bioinformatics Tools.

Notes:

Includes bibliographical references.

ISBN:

981-9751-65-9