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OrthoBiologics / Rachel M. Frank, Jorge Chahla, and Garrett Jackson, editors.
- Format:
- Book
- Language:
- English
- Subjects (All):
- Orthopedic surgery.
- Biological products--Therapeutic use.
- Biological products.
- Physical Description:
- 1 online resource (281 pages)
- Edition:
- First edition.
- Place of Publication:
- London, England : Academic Press, [2025]
- Summary:
- OrthoBiologics provides state-of-the-art knowledge of current biologic therapies for a variety of orthopaedic conditions in a single source.The content is presented in a straightforward manner, including defining all currently available orthobiologic options, discussing processing characteristics and appropriate clinical use, and finally.
- Contents:
- Front Cover
- OrthoBiologics
- Copyright Page
- Dedication
- Contents
- List of contributors
- Preface
- 1 Autologous blood: platelet-rich plasma and platelet-poor plasma
- Introduction
- Composition
- Platelet-rich fibrin
- Fibrin functions in regeneration
- Applications in orthopedics
- Ligament healing
- Meniscus healing
- Tendon healing
- Platelet-rich plasma in muscle healing
- Platelet-rich plasma in cartilage
- Conclusion
- References
- 2 Defining, measuring and optimizing platelet-rich plasma
- Defining platelet-rich plasma
- Commercial system platelet-rich plasma variability
- Proposed platelet-rich plasma classifications
- Quantifying platelet-rich plasma
- Benchside analysis point of care
- Future directions
- 3 Optimal use of platelet-rich plasma and platelet-poor plasma
- Platelet-rich plasma and platelet-poor plasma: overview
- Muscle healing
- Common clinical applications
- Rotator cuff disease
- Ulnar collateral ligament injuries
- Hip osteoarthritis
- Knee osteoarthritis
- Achilles tendinopathy
- Summary
- 4 Where orthobiologics started: what are mesenchymal stem cells?
- Orthobiologics: a historical overview
- What are mesenchymal stem cells?
- What mesenchymal stem cells are not
- Orthopedic applications of mesenchymal stem cells
- Avascular necrosis
- Fracture healing
- Cartilage restoration
- Ligamentous and tendinopathic injuries
- Spinal cord injuries
- 5 Bone marrow-derived mesenchymal stromal cells
- Harvest and preparation
- Senescence
- Regulations
- Bone marrow-derived mesenchymal stromal cells versus concentrated bone marrow aspirate
- Uses
- Osteoarthritis
- Focal cartilage defects
- Fractures
- Osteoporosis
- Osteogenesis imperfecta.
- Challenges for clinical application
- Social media
- Conflict of interests
- 6 Defining, optimizing, and measuring bone marrow aspirate and bone marrow concentrate
- Bone marrow extraction method
- Patient procedural preparation
- Review anatomical sites
- Unilateral versus bilateral
- Overview of bone marrow harvesting guidance techniques
- Bone marrow extraction techniques
- Bone marrow aspirate device designs and their overall differences in cellularity
- Differences between bone marrow aspirate and bone marrow concentrate
- Bone marrow aspirate as injectate+characteristics cellularity
- Bone marrow aspirate matrix as injectate+characteristics cellularity
- Bone marrow concentrate as injectate+characteristics cellularity+preparation consideration (cellular density separation)
- Literature summary of results Bone marrow application in osteoarthritis
- Bone marrow aspirate in osteoarthritis
- Bone marrow concentrate in osteoarthirits
- 7 Optimal clinical use of bone marrow aspirate and bone marrow aspirate concentrate
- Patient selection
- Clinical uses/outcomes
- Bone marrow aspirate concentrate in sports medicine
- Rotator cuff
- Lateral or medial epicondylitis
- Anterior cruciate ligament
- Patellar and achilles tendons
- Articular cartilage applications
- Bone marrow aspirate concentrate in osteoarthritis
- Bone marrow aspirate concentrate in trauma
- Bone marrow aspirate concentrate in spine
- Potential complications
- Further reading
- 8 Adipose tissue-derived stromal/stem cells
- Isolation and expansion of adipose tissue-derived stromal/stem cells
- Trilineage differentiation of adipose tissue-derived stromal/stem cells
- Factors influencing cell fate.
- Adipogenic differentiation
- Osteogenic differentiation
- Chondrogenic differentiation
- Adipose tissue-derived stromal/stem cells differentiation for tissue regeneration in vivo
- Bone regeneration
- Cartilage regeneration
- Chondroinduction by adipose tissue-derived stromal/stem cells
- Immunomodulation by adipose tissue-derived stromal/stem cells
- Immunoregulatory mechanisms
- Innate immune response
- Adaptive immune response
- Therapeutic application of immunomodulatory adipose tissue-derived stromal/stem cells
- 9 Defining, optimizing, measuring, and utilizing adipose, MFAT, etc.
- Adipose as a source of stem cells
- Adipose-derived stem cells
- Adipose tissue derivatives: SVF and MFAT
- Regulatory considerations
- Mechanism of adipose function
- Preparation of adipose stem cells
- Location
- Harvesting technique
- Isolation
- Storage
- Clinical application
- Bone
- Cartilage and meniscus
- Tendon
- Skin and wound healing
- Complications
- Limitations and shortcomings
- Next steps and future directions
- Conclusions
- 10 Optimal clinical use of adipose mesenchymal stromal cells
- Biology of adipose-derived mesenchymal stromal cells
- Origin and characteristics
- Mechanism of action in regenerative medicine
- Clinical use of adipose-derived mesenchymal stromal cells
- Overview of clinical indications
- Preparation approaches
- Patient selection and contraindications for harvest
- Applications
- Ankle osteoarthritis
- Shoulder osteoarthritis
- Chondral defects
- Tendon and ligament healing
- Lateral epicondylitis
- Rotator cuff tendinopathy/repair
- Patellar tendinopathy
- Anterior cruciate ligament tears
- Bone regeneration.
- Fracture healing
- Osteonecrosis
- Practical considerations
- Limitations and future directions
- Disclosure statement
- 11 Basic science and preclinical evidence for amniotic membrane−derived allografts in orthobiologics
- Sources and isolation of placental-derived orthobiologics
- Anatomy of placental-derived products
- Harvesting and processing of perinatal tissue
- Preclinical studies using amniotic membrane-derived products
- Challenges and limitations of using amniotic membrane-derived orthobiologics
- Difficulty in maintaining live mesenchymal stromal cells
- Lack of standardization
- Safety
- Current regulatory restriction on the use of amniotic membrane-derived products
- 12 Defining, optimizing, and measuring amniotic/placental mesenchymal stem cells
- Anatomy and function
- Formulation
- Collection
- Isolation and storage
- Effects of use
- In vitro
- In vivo
- Cartilage and bone
- Tendon injury
- Ligament injury
- Plantar fasciitis
- Spinal cord injury
- 13 Optimal clinical use of amniotic/placental mesenchymal stem cells
- History and basic science of birth tissue products
- Advantages and disadvantages of using amniotic/placental mesenchymal stem cells
- Current evidence of successful clinical use of amniotic/placental mesenchymal stem cells
- Knee
- Hip
- Tendinopathy
- Spine
- Future directions and challenges for the clinical use of amniotic/placental-derived allografts
- 14 Synovial mesenchymal stem cells
- Background
- Background on cartilage repair
- Cartilage injury and tissue damage response and consequences
- The synovium
- Synovial disorders
- Synovial analysis.
- Role of mesenchymal stem cells in cartilage regeneration
- Microfracture
- Bone marrow concentrate
- Synovial-derived mesenchymal stem cells
- Limits
- Mesenchymal stem cell repair
- Recruitment
- Signaling
- Exosomes
- The regulation and use of mesenchymal stem cells
- Synovial mesenchymal stem cells
- Properties of synovial mesenchymal stem cells
- Paracrine signaling
- Synovial-derived mesenchymal stem cells for cartilage repair
- Origin of synovial-derived mesenchymal stem cells
- Perivascular synovial-derived mesenchymal stem cells' highest chondrogenic potential
- Increased proliferation in synovial-derived mesenchymal stem cells
- Synovial-derived mesenchymal stem cell-derived exosomes
- Disclosures
- 15 Peripheral blood stem cells
- Developmental perspective hematology oncology
- Developmental background for cartilage repair
- Clinical applications of peripheral blood stem cell
- Articular cartilage regeneration and target patient population for K.A.R.T.®
- Food Drug Administration pathway
- Expanding indications for peripheral blood stem cells
- Shoulder cartilage
- Bone defects
- Osteochondral defects in the knee
- Osteochondral defects in the ankle
- Patellar tendinitis
- Achilles tendinitis
- Adductor tendinitis
- Ligament Injury
- Augmentation following surgical repair of tendons and ligaments
- Knee-recurrent dislocation of the patella
- Elbow-complete rupture of the radial collateral ligament and the common extensor origin
- Shoulder-massive rotator cuff tear
- Mechanism of action of musculoskeletal regeneration via peripheral blood stem stells
- 16 Orthobiologics-growth factors and mediators
- Growth factors.
- Platelet-derived growth factors.
- Notes:
- Includes bibliographical references and index.
- Description based on publisher supplied metadata and other sources.
- Description based on print version record.
- ISBN:
- 0-12-822903-9
- OCLC:
- 1453196001
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