Screening for hepatocellular carcinoma in adults at increased risk / Adrienne Landsteiner.

Format:

Book

Author/Creator:

Landsteiner, Adrienne, author.

Language:

English

Subjects (All):

Cancer--Treatment.

Cancer.

Physical Description:

1 online resource (x, 95 pages) : illustrations

Place of Publication:

Washington, DC : U.S. Department of Veterans Affairs, 2023.

Summary:

Screening for HCC among adults at increased risk (especially those with cirrhosis) has been recommended by several specialty societies (eg, American Association for the Study of Liver Diseases [AASLD], European Association for the Study of the Liver [EASL]) (typically through abdominal ultrasound imaging with AFP every 6 months) and is considered a quality metric for practice performance by AASLD. However, the National Cancer Institute's Physician Data Query concluded that based on fair evidence, screening of persons at elevated risk does not result in a decrease in mortality from HCC and would result in rare but serious side effects. The United States Preventive Services Task Force and other USA medical societies have not issued HCC screening guidelines. Questions surrounding screening include whether to conduct screening, the appropriate imaging technique if conducting screening (ultrasound, magnetic resonance imaging [MRI], computed tomography [CT]), use of AFP, screening intervals (eg, 3, 6, or 12 months), populations defined as increased or "at risk" and thus potential screening candidates, and when to discontinue screening.

Contents:

PREFACE

ACKNOWLEDGMENTS

Executive Summary

ABBREVIATIONS TABLE

BACKGROUND

METHODS

REGISTRATION AND REVIEW

ANALYTIC FRAMEWORK

KEY QUESTIONS AND ELIGIBILITY CRITERIA

SEARCHING AND SCREENING

DATA ABSTRACTION AND RISK OF BIAS ASSESSMENT

SYNTHESIS

RESULTS

LITERATURE FLOW DIAGRAM

OVERVIEW OF INCLUDED STUDIES

RANDOMIZED CONTROLLED TRIALS

CASE-CONTROL STUDIES

COHORT STUDIES

HCC COHORT STUDIES

DISCUSSION

FUTURE RESEARCH

CONCLUSIONS

REFERENCES

Appendix.

Notes:

Description based on publisher supplied metadata and other sources.