Engrams : A Window into the Memory Trace / edited by Johannes Gräff, Steve Ramirez.

Format:

Book

Contributor:

Gräff, Johannes, editor.

Ramirez, Steve, editor.

Series:

Advances in Neurobiology, 2190-5223 ; 38

Language:

English

Subjects (All):

Neurosciences.

Neuropsychology.

Psychobiology.

Neuroscience.

Biological Psychology.

Local Subjects:

Neuroscience.

Neuropsychology.

Biological Psychology.

Physical Description:

1 online resource (306 pages)

Edition:

1st ed. 2024.

Place of Publication:

Cham : Springer International Publishing : Imprint: Springer, 2024.

Summary:

This is the first book to extensively explore the current state-of-the-art and promise of engram cells, the closest physical approximation of the memory trace to date. Converging evidence suggests that memories are stored, at least in part, as specific populations of engram cells. In this book, the leading experts in engram biology share their continuously refined insights on how engram cells contribute to information encoding and storage, across diverse brain regions and behavioral modalities. “Engrams: A Window into the Memory Trace" is broad in scope and spans molecular, cellular, circuit, computational as well as societal-philosophical aspects of memory engrams. Particular emphasis is placed on their emerging translational value for memory dysfunctions in age and stress-related disorders. .

Contents:

Section I: Introduction

Engrams to remember – A conversation between Johannes and Steve

Section II: Engram cells and their mnemonic role across different brain structures

Engrams: From behavior to brain-wide networks

Memory storage in distributed engram cell ensembles

Hippocampal engrams and contextual memory

The role of prefrontal ensembles in memory across time – Time-dependent transformations of prefrontal memory ensembles

Section III: Insights into intra-engram functioning

All IEGs are not created equal – Molecular sorting within the memory engram

Unveiling transcriptional and epigenetic mechanisms within engram cells: Insights into memory formation and stability

The synaptic engram

Section IV: Beyond associative learning: Engrams for other memory processes

Engrams of fear memory attenuation

Adult neurogenesis, context encoding, and pattern separation: A pathway for treating overgeneralization

What can hippocampal engrams tell us about encoding spatial navigation?

Understanding others’ distress through past experiences: The role of memory engram cells in observational fear

Section V: Beyond the neurobiology of engrams

A computational framework for memory engrams

Engram studies: A call for historical, philosophical and sociological approaches

If engrams are the answer, what is the question?.

Notes:

Includes bibliographical references and index.

ISBN:

9783031629839