Molecular Mechanisms Determining Mammalian Oocyte Quality : Oocyte Developmental Competence, Aneuploidy, and Clinical Relevance / edited by Ahmed Z. Balboula.

Format:

Book

Author/Creator:

Balboula, Ahmed Z.

Series:

Advances in Anatomy, Embryology and Cell Biology, 2192-7065 ; 238

Language:

English

Subjects (All):

Reproduction.

Physiology.

Cytology.

Reproductive health.

Reproductive Physiology.

Cell Biology.

Reproductive Medicine.

Local Subjects:

Reproductive Physiology.

Cell Biology.

Reproductive Medicine.

Physical Description:

1 online resource (135 pages)

Edition:

1st ed. 2024.

Place of Publication:

Cham : Springer International Publishing : Imprint: Springer, 2024.

Summary:

As the age of childbearing increases, reduced female gamete (egg) quality has emerged as the primaery cause of infertility in women. This book addresses molecular mechanisms that regulate oocyte quality as well as intrinsic and extrinsic factors that compromise these mechanisms. Eggs are produced through a unique cell division called meiosis. Oocyte meiosis is initiated early in fetal life. Shortly before birth, the oocyte undergoes a prolonged arrest at prophase I until the age of puberty, at which selected oocytes resume meiosis I. Following meiotic resumption and during oocyte maturation, tight regulation of nuclear and DNA-related mechanisms ensures proper homologous chromosome segregation prior to another arrest at metaphase II. Any errors prior to completion of meiosis I can lead to chromosome segregation errors and aneuploidy, the most common genetic cause of miscarriage and congenital disorders such as Down syndrome. In addition to nuclear maturation, several cytoplasmic processes are orchestrated to support cell division and to generate developmentally competent eggs capable of supporting fertilization and early embryonic development. The interaction between these nuclear and cytoplasmic processes is critical for producing good-quality oocytes. This volume in the Advances in Anatomy, Embryology and Cell Biology book series presents current reviews by leading experts. It offers valuable insights for researchers, physicians and Ph.D. students interested in reproductive biology, particularly oocyte quality and meiosis.

Contents:

Chapter 1. Predicting Infertility: How Genetic Variants in Oocyte Spindle Genes Affect Egg Quality

Chapter 2. Regulation of Oocyte mRNA Metabolism: A Key Determinant of Oocyte Developmental Competence

Chapter 3. Mechanisms of DNA Damage Response in Mammalian Oocytes

Chapter 4. How do Environmental Toxicants Affect Oocyte Maturation via Oxidative Stress?

Chapter 5. Molecular Mechanisms Determining Mammalian Oocyte Quality with the Treatment of Cancer Therapy

Chapter 6. Telomere Elongation during Pre-implantation Embryo Development.

Notes:

Description based on publisher supplied metadata and other sources.

Other Format:

Print version: Balboula, Ahmed Z. Molecular Mechanisms Determining Mammalian Oocyte Quality

ISBN:

9783031551635

OCLC:

1449645789