Pharmacology in drug discovery and development : understanding drug response / Terry P. Kneakin.

Format:

Book

Author/Creator:

Kenakin, Terrence P., author.

Language:

English

Subjects (All):

Developmental pharmacology.

Pharmacology.

Drug development.

pharmacology.

Medical Subjects:

Pharmacology.

Physical Description:

1 online resource.

Edition:

Third edition.

Place of Publication:

London, United Kingdom : Academic Press, [2024]

Summary:

"Pharmacology in Drug Discovery and Development: Understanding Drug Response, Third Edition is an introductory resource that illustrates how pharmacology can be used to furnish the tools necessary to analyze different drug behavior and trace this behavior to its root cause or molecular mechanism of action. Chapters logically build upon one another to show how to characterize the pharmacology of any given molecule and allow for more informed predictions of drug effects in all biological systems. New chapters are dedicated to the interdisciplinary drug discovery environment in both industry and academia, and special techniques involved in new drug screening and lead optimization. The updates to the Third Edition include a new section converting “descriptive” data into “predictive” data through comparison to mathematical models, expansion on enzymes, drug metabolites and drug–drug interactions, and two new chapters. The newly developed companion website hosts further educational resources to complement the book. As in previous editions, this new edition includes numerous valuable chapter summaries, detailed references, practical examples, and case studies throughout"-- ScienceDirect.

Contents:

Pharmacology : the chemical control of physiology

Drug affinity and efficacy

Predicting agonist effect

Drug antagonism : orthosteric drug effects

Allosteric drug effects

Enzymes as drug targets

Pharmacokinetics I : permeation and metabolism

Pharmacokinetics II : distribution and multiple dosing

In vivo pharmacology

Safety pharmacology

The science of finding drug molecules I : applying pharmacology to discovery/target identification and validation

The science of finding drug molecules II : demonstrating target engagement and therapeutic value.

Notes:

Includes bibliographical references and index.

Online resource; title from PDF title page (SpringerLink, viewed June 10, 2024).

Other Format:

Print version: Kenakin, Terry P. Pharmacology in Drug Discovery and Development. Third edition

ISBN:

9780443141256

0443141258

OCLC:

1438795680

Publisher Number:

CIPO000079858

Access Restriction:

Restricted for use by site license