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The Rose and Mackay Textbook of Autoimmune Diseases / Edited M. Eric Gershwin, George C. Tsokos, and Betty Diamond, editors.
- Format:
- Book
- Series:
- ClinicalKey.
- ClinicalKey
- Language:
- English
- Subjects (All):
- Autoimmune Diseases.
- Autoimmune diseases.
- Medical Subjects:
- Autoimmune Diseases.
- Physical Description:
- 1 online resource (xxxii, 1719 pages) : illustrations (chiefly color)
- Edition:
- Seventh Edition.
- Other Title:
- Autoimmune Diseases
- Textbook of Autoimmune Diseases
- Place of Publication:
- London, England : Academic Press, 2024.
- System Details:
- datafile html
- datafile pdf
- text file PDF
- text file html
- Summary:
- **Selected for 2025 Doody's Core Titles® with "Essential Purchase" designation in Allergy/Clinical Immunology**The Rose-Mackay Textbook of Autoimmune Diseases, Seventh Edition is a comprehensive reference that emphasizes the "3 P's" of 21st Century medicine: precision, prediction, and prevention.
- The Rose-Mackay Textbook of Autoimmune Diseases, Seventh Edition is a comprehensive reference that emphasizes the "3 P’s" of 21st Century medicine: precision, prediction, and prevention. Topics cover the modern systems approach to biology that involves large amounts of personalized, ongoing physiologic data ("omics") coupled with advanced methods of analysis, new tests of genetic engineering, such as CRISPR, auto inflammatory diseases, autoimmune responses to tumor immunotherapy, and information on normal immune response and disorders. Each of the major autoimmune disorders is discussed by researchers and clinical investigators experienced in dealing with patients. This new edition continues its success with 75% of the content revised, updated, or completely new. This edition is a valuable resource to clinicians involved in the diagnosis and treatment of autoimmune disease, as well as to scientists who want to follow developments in the field. -- Publisher
- Contents:
- Part 1 Basic science: development of the immune system with cell lineages
- Part 2 - Rheumatology
- Part 3 - Nephrology
- Part 4 - Hematology
- Part 5 - Endocrinology
- Part 6 - GI and liver
- Part 7 - Cardiopulmonary diseases
- Part 8 - Ear Nose and Throat
- Part 9 - Ocular autoimmunity
- Part 10 - Autoimmune diseases of the skin
- Part 11 - Autoimmune disorders of the neurologic system
- 9780443239472v1_WEB
- Front Cover
- The Rose and Mackay Textbook of Autoimmune Diseases
- Copyright Page
- Dedication
- Contents to Volume 1
- List of contributors
- List of editors and section editors
- Editors
- Section editors
- Basic science
- Ear nose and throat
- Dermatology
- Endocrinology
- Hematology
- Hepatobiliary and gastroenterology
- Nephrology
- Neurology
- Ophthalmology
- Pulmonary
- Rheumatology
- Preface
- 1 Basic science: development of the immune system with cell lineages
- 1. Development of adaptive immune cells
- Self versus nonself
- Adaptive immune cell development
- Lymphocyte progenitors
- T cell development
- Altered mechanisms of T cell tolerance as promoters of autoimmunity
- B cell development
- Antibody diversity
- Self-reactive B cells are inherently part of the peripheral B cell pool
- Altered mechanisms of B cell tolerance and autoimmunity
- Conclusion
- Acknowledgment
- References
- 2. Revision to the origins of the mononuclear phagocyte
- Key points
- Overview
- Steady-state development of macrophages
- Transcriptional regulation of tissue-resident macrophages
- Common macrophage transcriptional profiles
- Adipose tissue macrophages
- Cardiac tissue macrophages
- Intestinal macrophages
- Kupffer cells
- Langerhans cells
- Peritoneal macrophages
- Lung macrophages
- Brain macrophages
- Nerve-associated macrophages
- Osteoclasts
- Splenic macrophages
- Synovial macrophages
- M1 and M2 paradigm revisited
- Future directions
- 3. Tolerance and activation of peripheral B and T cells
- B cell central tolerance "checkpoints" in humans
- Tonic signaling at the immature B cell stage
- Receptor editing is likely a dominant tolerance mechanism at the immature B cell stage in mice and humans.
- The special case of immature B cell deletion in response to DNA-protein complexes
- T cell activation, T-B collaboration, and peripheral B cell tolerance
- Self-reactive B cells at the transitional B cell stages are likely most susceptible to receptor downregulation and subseque...
- Late transitional and mature follicular B cells are anergized by selective downregulation of IgM, but anergic B cells are a...
- An overview of T cell tolerance and peripheral T cell activation
- The simultaneous generation of CD4+ T cell subsets and the induction of the extrafollicular response
- The transient extrafollicular induction of autoimmunity after infection likely reflects the major contribution of self-reac...
- The extrafollicular response, tolerance, and common autoimmune disorders
- Regulatory T cells in the maintenance of B cell tolerance
- Autoantibodies in common variable immunodeficiency likely reflect altered T effector/T reg ratios that allow anergic B cell...
- Germinal center B cell tolerance may reflect a default process and a break in tolerance at this location may lead to frank ...
- Acknowledgments
- 4. Genetic alterations leading to autoimmunity
- Introduction
- The genetics of autoimmunity before development of the genome-wide association study
- Evidence supporting the role of genetics in autoimmune diseases
- Linkage studies in autoimmune diseases
- Candidate gene studies identify the first non-HLA associated autoimmune disease risk genes
- The genome-wide association study
- Genome-wide association study discover a trove of autoimmune disease associations
- Fine mapping autoimmune disease loci with the Immunochip
- Moving from genetic association to functional mechanism in the post-GWAS era
- The next technology advance: single cell sequencing.
- Leveraging polygenic risk scores to predict disease
- Summary
- 5. Microbiome in autoimmunity
- Alterations in the gut microbiome in autoimmune diseases
- Inflammatory bowel diseases
- Type 1 diabetes
- Multiple sclerosis
- Rheumatoid arthritis
- Systemic lupus erythematosus
- Mechanisms
- Metabolites
- Molecules mimicry
- Microbiota translocation
- Interventions
- Diet and metabolites
- Fecal microbiota transplantation
- 6. Metabolic control of pathogenesis in autoimmune diseases
- Short summary
- Mitochondrial oxidative stress underlies mTOR activation in SLE
- Autoimmune spondyloarthritis
- Scleroderma and systemic sclerosis
- Metabolic control of organ-specific autoimmune diseases
- Conclusions
- 7. Triggers for autoimmunity
- Self-antigens that escape tolerance
- Neoantigens
- Breaking tolerance to existing autoantigens
- Enhanced presentation of posttranslationally modified epitopes
- Cryptic epitopes
- Sequestered antigens
- Environmental triggers of autoimmunity
- Viral-induced autoimmunity
- Epstein-Barr virus
- Enterovirus
- Hepatitis C virus
- Herpes simplex virus
- SARS-CoV-2
- Drug-induced autoimmunity
- Drug-induced lupus
- Potential mechanisms of drug-induced lupus
- Cellular autoimmunity
- Neutrophil extracellular traps
- Immune checkpoint inhibitor-induced autoimmunity
- Potential mechanisms of immune checkpoint inhibitor-induced autoimmunity
- Humoral autoimmunity
- Cytokine production
- 8. Organ damage in autoimmune disease.
- Introduction
- Initiation of tissue injury
- Antibody-mediated tissue injury
- Organ-specific diseases initiated by autoantibodies
- Autoantibodies of unknown function
- Antibodies directed at ubiquitous self-antigens
- B cells as organizers of local inflammation
- B cell-directed therapies
- T cell-mediated tissue injury
- T cells as inflammatory effector cells
- Antigen-specific T cells
- T cells as B cell helpers or regulatory cells
- T cell-directed therapies
- Innate immune mechanisms
- Macrophages
- Neutrophils
- Innate lymphoid cells
- Soluble inflammatory mediators
- Soluble mediators of resolution
- Chronic tissue injury
- Hypoxia
- Immune senescence
- Cell death
- Fibrosis
- Fibroblasts
- Pro-fibrotic and antifibrotic soluble mediators
- Targeting fibrosis
- Failed resolution
- Genetics of tissue injury
- Loss of function
- Implications for therapy
- 9. Therapeutic strategies for treating autoimmune disease
- Immunosuppression versus targeted therapy
- B cell depletion
- T cell-directed therapy
- Cytokine blockade
- Small molecule immune inhibitors
- Immunoablation and reconstitution
- Antigen-specific therapy
- 2 Rheumatology
- 10. Systemic lupus erythematosus
- History
- Disease diagnosis and classification
- Epidemiology, genetics, and the environment
- Pathogenesis
- Adaptive immunity
- Innate immunity
- Clinical features
- Clinical presentation
- Mucocutaneous manifestations
- Arthritis
- Renal involvement
- Neuro-psychiatric disease
- Hematologic manifestations
- Pulmonary and cardiovascular manifestations
- Other clinical manifestations
- Infections
- Clinical laboratory findings
- Treatment
- Outcome measures
- General therapeutic schema
- Therapeutic agents
- Antimalarials
- Corticosteroids
- Biologics.
- Immunosuppressive medications
- Calcineurin inhibitors
- Cyclophosphamide
- Supportive treatments
- 11. Systemic sclerosis (scleroderma)
- Definition and classification
- Epidemiology and etiology
- Sex bias, ethnic background and mortality trends
- Environmental factors
- Genetic associations
- Preclinical disease models
- Microvascular disease in systemic sclerosis
- Inflammation and autoimmunity
- Cellular immunity
- Pathology
- Skin
- Lungs
- Gastrointestinal tract
- Kidneys
- Heart
- Pathology in other organs
- Initial clinical presentation
- Organ involvement
- Raynaud's phenomenon
- Skin features
- Pulmonary features
- Interstitial lung disease
- Gastrointestinal involvement
- Renal involvement: scleroderma renal crisis
- Cardiac involvement
- Musculoskeletal complications
- Less recognized disease manifestations
- Biomarkers and autoantibodies in systemic sclerosis
- Screening and follow-up evaluation
- Management of patients with systemic sclerosis
- General principles
- Disease-modifying immunomodulatory therapy
- Therapy targeting fibrosis
- Vascular therapy
- Treatment of gastrointestinal complications
- Treatment of interstitial lung disease
- Management of renal crisis
- Treatment of pulmonary arterial hypertension
- Natural history and prognosis
- 12. Antiphospholipid syndrome
- Historical perspective
- Geoepidemiology
- Double-hit model
- Thrombosis
- Activation of endothelial cells, platelets and immune cells
- Complement activation
- Resistance to activated protein C
- Pregnancy complications
- Proliferation and migration of trophoblasts
- Inflammation
- Genetics
- Diagnosis, screening, and prevention.
- Antiphospholipid antibody assays.
- Autoimmune pancreatitis / Reza V. Milano; Camilo J. Acosta; Russ Kuker; Jodie A. Barkin
- Primary biliary cholangitis / Cynthia Levy
- Notes:
- Includes bibliographical references.
- Description based on publisher supplied metadata and other sources.
- Description based on print version record.
- Other Format:
- Also issued in print: Rose and Mackay Textbook of Autoimmune Diseases
- ISBN:
- 9780443239472
- 0443239479
- 9780443239465 (hardcover ; set)
- 0443239460 (hardcover ; set)
- 9780443289309 (hardcover ; v. 1)
- 0443289301 (hardcover ; v. 1)
- 9780443289316 (hardcover ; v. 2)
- 044328931X (hardcover ; v. 2)
- OCLC:
- 1451805644
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