Diagnostic, Prognostic, and Therapeutic Role of MicroRNAs in Head and Neck Cancer / Ashok Kumar [and three others], editors.

Format:

Book

Contributor:

Kumar, Ashok, editor.

Language:

English

Subjects (All):

Head--Cancer--Diagnosis.

Head.

Head--Cancer.

Physical Description:

1 online resource (363 pages)

Edition:

First edition.

Place of Publication:

London, England : Academic Press, [2024]

Summary:

Early diagnosis of HNSCC can cause improved treatment, treatment response rates and reduction in mortality rates.Recently, miRNA-based diagnostics and therapeutics have gained considerable attention among the scientific community.

Contents:

Front Cover

Diagnostic, Prognostic, and Therapeutic Role of MicroRNAs in Head and Neck Cancer

Copyright Page

Contents

List of contributors

1 Epidemiology, pathology, and genomic topography of head and neck cancers

1.1 Introduction

1.2 Epidemiology of head and neck cancer

1.3 Risk factors

1.3.1 Tobacco

1.3.2 Alcohol

1.3.3 Human papillomavirus

1.4 Squamous cell carcinoma

1.4.1 Precursors

1.4.1.1 Leukoplakia

1.4.1.2 Erythroplakia

1.4.1.3 Squamous dysplasia

1.4.1.4 Proliferative verrucous leukoplakia

1.4.2 Histologic variant

1.4.2.1 Verrucous squamous cell carcinoma

1.4.2.2 Basaloid squamous cell carcinoma

1.4.2.3 Spindle cell squamous cell carcinoma

1.5 Genetic landscape of head and neck cancer

1.5.1 Comprehensive genetic analysis of head and neck squamous cell carcinoma

1.5.2 Mutations

1.5.3 Copy number alterations

1.6 Signaling pathway associated with head and neck squamous cell carcinoma

1.6.1 Epidermal growth factor receptor pathway

1.6.2 Mitogen-activating protein kinase pathway

1.6.3 Phosphoinositide 3-kinase/Ak strain transforming/Mammalian target of rapamycin pathway

1.6.4 Janus kinase/Signal transduction and transcription activation pathway

1.6.5 Hepatocyte growth factor/mesenchymal-epithelial transition pathway

1.6.6 p53

1.6.7 Nuclear factor kappa B pathway

1.6.8 Wnt/β-catenin and Notch pathway

1.7 Genetic heterogeneity

1.7.1 Interpatient

1.7.2 Intratumoral

1.7.3 Intermetastatic

1.7.4 Intrametastatic

1.8 Management

1.8.1 Diagnosis

1.8.2 Clinical presentation

1.8.3 Histopathology

1.8.4 Tumor excision and surgical margins

1.8.5 Precision medicine

1.9 Conclusion

Acknowledgment

References

2 Association of human papillomavirus with head and neck cancers.

2.1 Head and neck cancers: pathogenesis, incidence, and mortality

2.2 Risk factors for head and neck cancers

2.3 Human papillomavirus: history, genome, and mode of infection

2.3.1 Mechanisms associated with human papillomavirus-induced oncogenesis

2.4 Epidemiology and regional differences in incidence of human papillomavirus-positive head and neck cancer

2.4.1 Determination of human papillomavirus status

2.5 Differences in mutational signatures between human papillomavirus-positive and human papillomavirus-negative head and n...

2.6 Clinical implications of human papillomavirus positivity in head and neck cancers

2.7 Conclusion

3 MicroRNA regulation of different subtypes of head and neck malignancies

3.1 Introduction

3.2 MicroRNAs: biogenesis and role in cancer

3.3 miRNA regulation of head and neck malignancies

3.4 Role of miRNAs in different subtypes of head and neck malignancies

3.4.1 Oropharyngeal cancer

3.4.2 Hypopharyngeal cancer

3.4.3 Laryngeal cancer

3.4.4 Lip and oral cavity cancer

3.4.5 Nasopharyngeal cancer

3.4.6 Paranasal sinus and nasal cavity cancer

3.4.7 Salivary gland cancer

3.4.8 Soft tissue sarcoma

3.4.9 Thyroid cancer

3.5 Conclusion

4 Oncogenic and tumor suppressor microRNAs in head and neck cancer

4.1 Introduction

4.1.1 MiRNA and its role

4.1.2 MiRNA in the genome

4.1.3 Cellular impact of miRNA-miRNA interactions

4.1.4 MiRNA biogenesis and regulation

4.1.5 Transcriptional control of miRNAs

4.1.6 Impact of altered miRNA expression in tumors

4.1.6.1 Cell cycle progression

4.1.6.2 Invasion and metastasis

4.1.6.3 Angiogenesis

4.1.6.4 Cell death inhibition

4.2 miRNA deregulation in head and neck cancer

4.2.1 Oncogenic miRNAs

4.2.1.1 miR-21

4.2.1.2 miR-31

4.2.1.3 miR-134.

4.2.1.4 miR-146a

4.2.1.5 miR-211

4.2.2 Tumor suppressor miRNA

4.2.3 Mechanism of miRNAs dysregulation and cancer development

4.2.4 Effect of miRNA deregulation on signaling pathways

4.2.4.1 miRNAs and PI3K/AKT pathway

4.2.4.2 Wnt/β-catenin signaling pathway

4.2.4.3 miRNAs and epidermal growth factor receptor pathway

4.3 Conclusion

5 Epigenetic regulation of head and neck cancer by microRNAs

5.1 Introduction

5.2 MicroRNAs: a distinct class of noncoding RNAs

5.3 Epigenetics: an epicenter in the regulation of gene expression

5.4 Epigenetics and methylomics of head and neck cancer

5.4.1 DNA hypomethylation and hypermethylation

5.4.2 Histone modifications and chromatin remodeling

5.5 Role of microRNAs in head and neck cancer

5.6 Conclusion

Acknowledgments

6 Association of genetic variations in microRNAs with susceptibility to head and neck cancer

6.1 Introduction

6.2 miR-146a role in head and neck cancer susceptibility

6.3 miR-149 role in head and neck cancer susceptibility

6.4 miR-196a2 role in head and neck cancer susceptibility

6.5 miR-605 and its role in head and neck cancer susceptibility

6.6 miR-608 and its role in head and neck cancer susceptibility

6.7 miR-499 and its role in head and neck cancer susceptibility

6.8 Conclusion and future perspectives

7 Role of microRNAs in metastasis, recurrence, and chemoradiation resistance of head and neck cancer

7.1 Introduction

7.2 Head and neck squamous cell carcinomas and miRNAs

7.3 Role of miRNAs in metastasis of head and neck squamous cell carcinomas

7.4 Role of miRNAs in the recurrence of head and neck squamous cell carcinomas

7.5 The role of microRNAs in radioresistance and chemoresistance in head and neck squamous cell carcinomas

7.6 Conclusion

References.

8 Regulation of head and neck tumor microenvironment by microRNAs

8.1 Introduction

8.2 Role of miRNA in regulating various cell types in tumor microenvironment

8.2.1 Cancer-associated fibroblasts

8.2.2 Immune cells

8.2.3 Endothelial cells

8.2.4 Extracellular matrix

8.3 Regulation of tumor microenvironments by various miRNAs

8.3.1 miR-21

8.3.2 miR-31

8.3.3 miR-34a

8.3.4 miR-155

8.3.5 miR-214

8.3.6 miR-200

8.3.7 miR-503

8.3.8 miR-29

8.4 miRNAs in head and neck squamous cell carcinoma metabolism

8.4.1 miR-218, miR-10a, and miR-340

8.4.2 miR-143 and miR-125-b-5p

8.4.3 miR-210

8.4.4 miR-31-5p

8.4.5 Mixed role miRNAs

8.5 Regulation of cancer stemness by miRNAs

8.5.1 miRNA as oncogenic factor

8.5.2 miRNA as a tumor suppressor

8.5.3 miRNA as dual function regulator

8.6 Role of hypoxia in regulating malignancy

8.6.1 Hypoxia and tumor microenvironment

8.6.2 miRNA and hypoxia in head and neck squamous cell carcinoma

8.7 Exosomal miRNA and the tumor microenvironment: intercellular communication and disease pathogenesis

8.7.1 Exosome secretion process and its effect on the tumor microenvironment

8.7.2 Exosomal miRNA and its role in modulating tumor microenvironment in head and neck cancer

8.8 MicroRNAs in targeting molecular pathways in head and neck squamous cell carcinoma

8.8.1 Epidermal growth factor receptor pathway

8.8.2 PI3K/Akt/mTOR pathway

8.8.3 Wnt pathway

8.8.4 Mitogen-activated protein kinase pathway

8.9 Therapeutic avenue to target head and neck squamous cell carcinoma using microRNA

8.10 Conclusion

9 Genome-wide discovery and prediction of microRNA-based biomarkers in head and neck squamous cell carcinoma

Abbreviations

9.1 Introduction

9.2 Overview of miRNA biomarkers

9.2.1 miRNA and cancer.

9.3 Genome-wide discovery of miRNA biomarkers

9.3.1 Discovery and prediction of novel miRNA biomarkers

9.3.1.1 Classical forward genetics

9.3.1.2 miRNA cloning

9.3.2 The generations of sequencing

9.3.2.1 First-generation of sequencing

9.3.2.2 Second-generation of sequencing

9.3.2.2.1 Roche 454 Pyrosequencing

9.3.2.2.2 Illumina (Solexa) HiSeq and MiSeq sequencing

9.3.2.2.3 Sequencing by oligonucleotide ligation and detection

9.3.2.2.4 Ion Torrent

9.3.3 Computational approaches to miRNA discovery

9.3.3.1 miRScan

9.3.3.2 Phylogenetic shadowing

9.3.3.3 miRanalyzer

9.4 Toward personalized therapy in head and neck squamous cell carcinoma using next-generation sequencing - future perspective

9.5 Conclusion

10 Computational modeling for identification of microRNAs as diagnostic and prognostic biomarkers for head and neck cancer

10.1 Introduction

10.2 microRNA databases

10.3 Types of computational models

10.3.1 Statistical models

10.3.2 Machine learning-based models

10.3.3 Deep learning-based models

10.3.4 Complex-network algorithm-based models

10.4 Pros and cons of different models

10.5 Conclusion

11 Development of microRNA as prognostic markers in head and neck cancer

11.1 Introduction

11.2 miRNAs in head and neck cancer

11.2.1 Oncogenic miRNA

11.2.2 Tumor-suppressive miRNA

11.3 miRNA as a prognostic biomarker in head and neck cancer

11.3.1 miRNA as a prognostic biomarker of progression-free survival (PFS)

11.3.2 miRNA as a prognostic biomarker of disease-free survival (DFS)

11.3.3 miRNA as a prognostic biomarker of overall survival (OS)

11.4 MicroRNA as a biomarker in head and neck cancer

11.4.1 Combined miRNA expression

11.4.2 Multiple miRNA expression analysis.

11.4.2.1 Head and neck squamous cell carcinoma.

Notes:

Includes bibliographical references and index.

Description based on publisher supplied metadata and other sources.

Description based on print version record.

ISBN:

9780443159695

0443159696

OCLC:

1451414736