Cancer Epigenetics and Nanomedicine : Targeting the Right Player Via Nanotechnology.

Format:

Book

Author/Creator:

Kesharwani, Prashant.

Contributor:

Thakur, Chitra.

Language:

English

Subjects (All):

Epigenetics.

Nanomedicine.

Physical Description:

1 online resource (460 pages)

Edition:

1st ed.

Place of Publication:

San Diego : Elsevier Science & Technology, 2024.

Summary:

This book, 'Cancer Epigenetics and Nanomedicine: Targeting the Right Player,' edited by Prashant Kesharwani and Chitra Thakur, explores the complex interplay between cancer epigenetics and nanotechnology in developing targeted cancer therapies. It delves into the mechanisms of cancer, including tumor metabolism, the role of one-carbon amino acids, and environmental causes of cancer. The book underscores the significance of epigenetic modifications in cancer progression and treatment, discussing DNA methylation, histone modifications, and chromatin remodeling as pivotal factors in cancer biology. Additionally, it highlights the potential of nanomedicine in delivering targeted treatments by modulating epigenetic pathways. Aimed at researchers, practitioners, and students in oncology and medical sciences, this book provides insights into the latest advancements in cancer treatment, emphasizing the integration of epigenetic and nanotechnology approaches to improve therapeutic outcomes. Generated by AI.

Contents:

Intro

Cancer Epigenetics and Nanomedicine: Targeting the Right Player via Nanotechnology

Copyright

Contents

Contributors

About the editors

Preface

Acknowledgments

Section 1: Overview of cancer, internal and external factors associated with cancer

Chapter 1: Overview of cancer: Mechanisms of carcinogenesis

Introduction

Cancer: A historical perspective

Origin of cancer: Theories and drivers of carcinogenesis

Theories of cancer origin

Mechanisms of carcinogenesis

Endogenous and exogenous factors affecting DNA

DNA repair

Oncogenes and tumor suppressor genes

Sustained proliferation

Cell death and resistance

Angiogenic switch

Tissue invasion and metastasis

The tumor microenvironment

Hallmarks of cancer

Epigenetics and cancer

DNA methylation in cancer

Histone modifications

Nucleosome positioning

Noncoding RNAs

Conclusion

References

Chapter 2: Tumor metabolism and micronutrients: New insights to target malignant tumors

Role of micronutrients in targeting malignant tumors

Impact of iron levels on cancer proliferation

Targeting intracellular iron levels to induce cellular death

Impact of calcium levels on cancer proliferation

Targeting calcium levels to induce cellular death

Impact of magnesium levels on cancer proliferation

Targeting Warburg effect to induce tumor cell death

Role of glycolytic enzymes in inducing cancer cell death

Other metabolic pathways used by tumor cells

Interplay between glutaminolysis and Warburg effect

Discussion and conclusion

Author contributions

Conflict of interest

Chapter 3: The role of one-carbon amino acids in tumor-immune metabolism: From oncogenesis to therapy

One-carbon metabolism

Methionine

Serine.

One-carbon metabolism and T-cell function

Dependency of methionine metabolism in T-cells

Dependency of serine metabolism in T-cells

Restriction of AAs as therapy

Therapeutic restriction of methionine

Therapeutic restriction of serine

Conclusion and future directions

Chapter 4: Environmental causes of cancer

Smoking and tobacco use

Radiation

Alcohol consumption

Diet and obesity

Air pollution

Water pollution

Soil pollution

Lead

Cadmium

Polycyclic aromatic hydrocarbons

Asbestos

Pathogenic microbes

Environmental carcinogens

Aflatoxins

Benzene

Hexavalent chromium compounds

Perspectives

Chapter 5: Cancer stem cells-Challenges for cancer therapies

The identification of the CSCs

CSCs in tumorigenesis models

Biology of CSCs

Challenges posed by CSCs in cancer therapies

Ambiguity of the CSC markers

Crosstalk among the regulatory pathways

CSC-mediated tumor dormancy

Enhanced drug efflux activity of CSCs

Increased DNA repair in CSCs

Enhanced autophagy and mitophagy in CSCs

Suppressed ferroptosis in CSCs

Metastatic potential of CSCs

Hypoxic adaptation

CSCs generate a tumor supporting niche

Epigenetic regulation

Perspective

Chapter 6: Carving a therapeutic niche for metastatic cancer: Opportunities and challenges

History of metastasis

Mechanism of metastasis

Challenges for therapy of metastasis

Section 2: Epigenetics and its importance in cancer therapies

Chapter 7: An overview of epigenetics and cancer

Role of epigenetics in normal and cancer cells

Epigenetics mechanism and their regulation on cancer

Role of histone modifications in cancer.

Chromatin remodeling in cancer

Alterations in chromatin remodeling enzymes

Aberrations in nucleosome positioning

DNA methylation and histone methylation cross-talks

Role of epigenetic dysregulation of noncoding RNAs in cancer

Epigenetic dysregulation in cancer stem cells, a promise for therapeutic intervention

Epigenetics in the clinics: Prognostics, diagnostics, and therapeutic intervention for cancers

Harnessing epigenetics mechanism in prognosis and diagnosis of cancer

Epigenetic therapy: A targeted approach to cancer treatment

Advancements and innovation in epigenetic technologies in investigating mechanisms in cancer cells

Epigenetic profiling

Epigenome editing

Single-cell epigenomics

Chapter 8: Metabolic adaptation and epigenetic modulations: Unraveling tumor plasticity under variable tumor microenvironment

Metabolic adaptation to TME

Metabolic microenvironment in solid tumors

TME altered metabolic pathways

Glucose metabolism

Amino acid metabolism

Lipid metabolism

Metabolic reprogramming via transcription factors in the TME

p53

HIFs

NF-κB

ROS and redox signaling in a harsh TME

Epigenetic and metabolic crosstalk in TME

DNA methylation

RNA methylation

Chromatin modifications

Chromatin remodeling

Histone methylation

Histone acetylation

Histone lactylation

Noncoding RNA

lncRNA

miRNA

Metabolic plasticity

Epigenetic modifications in shaping the TME

Epithelial-mesenchymal plasticity

Cancer cell dormancy

Intratumor heterogeneity leading to phenotypic variation

Chapter 9: Involvement of epigenetic modifications in cancer stem cells and chemoresistance

Tumor heterogeneity and drug resistance

Cancer stem cells: A new dimension to drug resistance.

Reprogramming of cancer stem cells and epigenetic modifications

Histone methylation and demethylation

Histone acetylation and deacetylation

Micro-RNAs (miRNA)

Long noncoding RNAs (lncRNA)

Epigenetic involvement in drug resistance

Therapeutic targeting of epigenetic alterations in cancers

DNMT inhibitors

Histone deacetylase (HDAC) inhibitors

Histone methyltransferase inhibitors

Combinatorial strategies for epigenetic therapeutics

Chapter 10: Cancer biomarkers: Where genetics meets epigenetics

Epigenetics in cancer biology

Histone PTMs as cancer biomarkers

Chromatin remodeling complexes

miRNAs in cancer

miRNA-based therapeutic strategies

Chapter 11: Epigenetics approach in cancer treatment with focus on lung and breast cancer

Introduction to epigenetics in breast and lung cancer

DNA methylation in breast and lung cancer

Chromatin remodeling and HDAC inhibition

Role of miRNAs as epigenetic biomarkers

Scope of epidrugs

Future directions

Chapter 12: Dietary components as epigenetic modifiers and their roles in cancer prevention

Epigenetic mechanisms and its importance in cancer

Crosstalk between dietary components and metabolism in epigenetic regulation

Types of dietary components and their role in epigenetics and chemoprevention

Dietary polyphenols

Epigallocatechin-gallate

Sulforaphane

Resveratrol

Curcumin

Quercetin

Genistein

Section 3: Nanomedicine targeting epigenetic machinery in cancer therapy.

Chapter 13: Harnessing plant-derived biosynthetic nanomaterials for epigenetic modulation in cancer therapy

Epigenetic modulation in cancer

Current approaches for epigenetic modulation in cancer therapy

Biosynthetic nanomaterials from plants

Plant-based nanomaterials used in cancer research

Plant-derived nanoparticles

Plant secondary metabolites

Plant-based polymeric nanoparticles

Epigenetic modulation by biosynthetic nanomaterials

Plant-derived nanoparticles for targeted delivery of epigenetic modifiers

Plant secondary metabolites as natural epigenetic modulators

Plant-based polymeric nanoparticles for sustained release of epigenetic drugs

Experimental evidence and preclinical studies

Clinical potential and future directions

Chapter 14: Nanotechnology-enhanced immunotherapy for cancer

The fundamentals of the immune system

T-cell ontogeny

T-cell activation signals

Tumor immunology

Immune responses against tumors

Adoptive T-cell therapy for combating cancers

Immune checkpoints and their role in cancer immunotherapy

CTLA-4

PD-1/PD-L1 pathway

TIGIT

LAG3

Other therapies

Nanotechnological advances in immunotherapy

Chapter 15: Nanoparticles in metastatic cancer treatment

Understanding metastasis in cancer

NPs for drug delivery

Fundamentals and rationale for using NPs in cancer treatment

Applications of NPs for drug deliverance

Targeted drug delivery methodologies

Passive targeting: EPR effect (enhanced permeability and retention)

Active targeting

Intracellular/intramolecular targeted therapies

Applications in metastatic cancer treatment

Conclusion and future perspectives

References.

Chapter 16: Amine-terminated dendrimers: A novel method for diagnose, control and treatment of cancer.

Notes:

Description based on publisher supplied metadata and other sources.

Part of the metadata in this record was created by AI, based on the text of the resource.

Other Format:

Print version: Kesharwani, Prashant Cancer Epigenetics and Nanomedicine

ISBN:

9780443132100

OCLC:

1443080859