Macrophages biology and tissue inflammation in health and disease / edited by Stuart Goodman, Michiaki Takagi, and Jiri Gallo.

Format:

Book

Contributor:

Goodman, Stuart, editor.

Takagi, Michiaki, editor.

Gallo, Jiri, editor.

Language:

English

Subjects (All):

Inflammation--Immunological aspects.

Inflammation.

Macrophages.

Physical Description:

1 online resource (202 pages)

Edition:

First edition.

Place of Publication:

London, England : Academic Press, [2024]

Summary:

This book explores the biology of macrophages and their role in inflammation, tissue repair, and regeneration. It provides an in-depth analysis of the cellular and molecular mechanisms of inflammation, distinguishing between acute and chronic types. The text also examines the interaction between macrophages and other cells, their involvement in diseases such as arthritis and cancer, and their potential in tissue engineering and regenerative medicine. The authors, experts in orthopaedic surgery and related fields, aim to enhance understanding of macrophage behavior for improved therapeutic strategies. The book is intended for researchers and practitioners in medicine and biomedical sciences. Generated by AI.

Contents:

Intro

Macrophages Biology and Tissue Inflammation in Health and Disease

Copyright

Contents

Contributors

Chapter 1: Inflammation and macrophage development

1. Inflammation

2. Local immune response

3. Role of macrophages in inflammation, tissue repair, and regeneration

4. Macrophage development

5. Macrophages populations

6. Tissue-resident macrophages

References

Chapter 2: Acute and chronic inflammation

1. General features of inflammation

2. Proinflammatory threats

3. Acute inflammation

4. Chronic inflammation

5. New insights of TRMs in inflammation

6. Systemic effect of inflammation

Chapter 3: Phenotype and function of macrophages is regulated by chemokines

1. Chemokines

2. Chemokines and their receptors in macrophages

2.1. Macrophage plasticity and heterogeneity

2.1.1. Heterogeneity of macrophages

2.1.2. Plasticity of macrophages

3. Chemokines in homeostasis and inflammation

4. Chemokines in diseases of the musculoskeletal system

4.1. Chemokines in bone remodeling

4.2. Chemokines in osteoporosis

4.3. Chemokines mediating pathologic response to orthopedic implants

4.4. Chemokines in osteoarthritis

4.5. Chemokines in rheumatoid arthritis

5. Chemokines in the therapy

Chapter 4: Cross talk between macrophages and other cells

1. Introduction

2. How does cellular cross talk occur?

2.1. Macrophages and cell-to-cell contact

2.2. Macrophage communication via soluble factors

2.3. Extracellular vesicles, exosomes, and microvesicles

2.4. Macrophage extracellular traps (METs)

3. Discussion

3.1. Where we are now

3.2. Opportunities

4. Conclusion

Acknowledgments

Chapter 5: Macrophages in tissue engineering and regeneration.

1. Macrophage polarization: From inflammation to regeneration

2. Mesenchymal stem cell-macrophage cross talk

2.1. Macrophage production of growth factors

3. Regeneration

3.1. Bone

3.2. Skeletal muscle

3.3. Skin

4. Regeneration vs. fibrosis

5. Macrophages in tissue engineering

5.1. Bone

5.2. Skin

5.3. Treatment of inflammatory dysregulation/chronic inflammation

6. Conclusion

Chapter 6: Macrophages and the musculoskeletal system

2. Tissue-specific macrophages in healthy musculoskeletal tissues

3. Synovial macrophages and joint fluid production

3.1. Synovium

3.2. Joint fluid production

3.3. Joint fluid workup

4. Macrophages in inflammatory musculoskeletal diseases

4.1. Rheumatoid arthritis

4.2. Seronegative spondyloarthritis

4.3. Psoriatic arthritis

4.4. Reactive arthritis

5. Macrophages in noninflammatory musculoskeletal diseases

5.1. Osteoarthritis (OA)

5.2. Macrophages in the intervertebral disc pathology

5.3. Macrophages in tendinopathy and tendinitis

5.4. Macrophages in enthesopathy

5.5. Macrophages in the healing of traumatic injuries

5.6. Macrophages in osteoporosis

6. Macrophages in biomaterial-associated complications

6.1. Macrophages around stable total joint arthroplasty

6.2. Macrophages in aseptic loosening/periprosthetic osteolysis

6.3. Macrophages in prosthetic joint infection

7. Macrophages in orthopedic infections

7.1. Osteomyelitis, spondylodiscitis

7.2. Septic arthritis

8. Macrophages in musculoskeletal tumors

8.1. Tumor microenvironment (TME) concept

8.2. Tumor-associated macrophages

8.3. Role of macrophages in metastasis

8.4. Why bone and not skeletal muscle is preferential metastatic site?

9. Macrophages in aging MS system

9.1. Multiple myeloma.

9.2. Sarcopenia-Skeletal muscle aging and macrophages

9.3. Musculoskeletal stiffness and inflammaging

9.4. Can aging be slowed via affecting the macrophages?

10. Conclusion

Chapter 7: Future research and applications

2. Macrophage-assisted immunomodulation

3. Macrophage-assisted tissue healing, regeneration, or substitution

4. Macrophage-assisted strategies for maintenance of healthy implant-tissue interfaces

5. Macrophage-assisted antiinfective approaches

6. Macrophage-assisted antiaging and resilience strategies

7. Bioinformatic approaches to estimation of macrophage behavior

8. Conclusion

Acknowledgment

Chapter 8: Conclusion

Index.

Notes:

Includes bibliographical references and index.

Description based on publisher supplied metadata and other sources.

Part of the metadata in this record was created by AI, based on the text of the resource.

Description based on print version record.

ISBN:

0-12-821762-6

OCLC:

1443081196