Cancer through the Lens of Evolution and Ecology / edited by Jason Somarelli and Norman Johnson.

Format:

Book

Contributor:

Somarelli, Jason, editor.

Johnson, Norman A., editor.

Taylor & Francis eBooks

Language:

English

Subjects (All):

Cancer.

Epigenetics.

Evolution (Biology).

Neoplasms.

Medical Subjects:

Neoplasms.

Physical Description:

1 online resource (1 online reosurce (xx, 194 pages)

Place of Publication:

[Boca Raton, FL] : CRC Press, 2024.

Biography/History:

Jason A. Somarelli is a molecular biologist, who received his doctoral degree from Florida International University in Miami, FL and was an American Cancer Society postdoctoral fellow at Duke University. He is currently an Assistant Professor in the Department of Medicine at Duke University. Somarelli serves as the Director of Research for the Duke Cancer Institute Comparative Oncology Group and is the Director of the Duke University Marine Laboratory Scholars in Marine Medicine Program. Dr. Somarelli⁰́₉s research uses evolutionary and ecology paradigms to understand molecular adaptations to extreme environments. His work spans diverse topics, such as the evolutionary pressures faced by cancer cells during drug treatment and metastatic spread, the molecular adaptations of whales and other marine mammals to low oxygen conditions, and the evolution of microbes to use plastic as a nutrient source. In addition to his scholarly activities, Dr. Somarelli is passionately involved in training and education, leading multiple outreach and research training programs for high school students and undergraduates in an effort to enhance diversity in STEM careers. Norman A. Johnsonis an evolutionary geneticist, who received his doctoral degree from the University of Rochester and was a postdoctoral fellowat the University of Chicago. He is now an adjunct professor in the Biology department at the University of Massachusetts at Amherst. Johnson has also taught at the University of Chicago, the University of Texas at Arlington, and Hampshire College. Most of his research has been on the genetics and evolution of why hybrids between species are often sterile or inviable. Other research interests include the evolution of sex chromosomes, the evolution of extremely large dietary niches in insects, conflict between different parts of the genome, and the interplay between the relaxation of selection and the loss of traits. Johnson⁰́₉s first book,Darwinian Detectives: Revealing the Natural History of Genes and Genomes(Oxford University Press, 2007), examines how biologists infer the action of natural selection and other evolutionary processes from DNA sequence information. More recently, hewroteDarwin⁰́₉s Reach: 21st Century Applications of Evolutionary Biology(CRC Press, 2022). This book explores how ideas and information from evolutionary are being used in diverse ways in the realms of health, food, the environment, and society at large. Dr. Johnson has been active in science communication and outreach; notably, he co-led the National Evolutionary Synthesis Center working group on communicating the relevance of human evolution.

Contents:

ForewordRandolph NesseChapter 1: A species within a speciesJason A. Somarelli and Norman A. JohnsonChapter 2: Therapy As a Driver of Evolutionary SelectionDana Ataya, Joel S. Brown and Robert A. GatenbyChapter 3: The Genetic Hitchhiker⁰́₉s Guide to Tumor EvolutionRohini Janivara and Joseph LachanceChapter 4: Multicellularity, phenotypic heterogeneity, and cancerChristopher Helenek, Jason A. Somarelli, and G©Łbor Bal©ŁzsiChapter 5: Feedback loops in gene regulatory networks and cell-cell communication networks: drivers of cancer cell plasticityYeshwanth Mahesh, Subbalakshmi Ayalur Raghu, Mohit Kumar JollyChapter 6: Polygenic Evolution of Germline Variants in CancerUjani Hazra and Joseph LachanceChapter 7: Two-phased cancer evolution: the pattern and scale of genomic and nongenomic landscapesAndrzej Kasperski and Henry H. HengChapter 8: Evolutionary and ecological perspective on the multiple states of T cell exhaustionIrina Kareva and Joel S. BrownChapter 9: Landscape Genetics for Cancer BiologyErin L. Landguth and Norman A. JohnsonChapter 10: Tumor Island Biogeography: Theory and Clinical ApplicationsAntonia ChroniChapter 11: Cancer and the Evolutionary Ecology of InvasionsJoel S. Brown, Sarah A. Amend and Kenneth J. Pienta Chapter 12: Unifying Theories in Comparative Oncology Zachary T. Compton Chapter 13: From Evolutionary Biology to Bedside and Beyond: A View of Comparative Oncology Throughout the Translational PipelineVeronica Colmenares, William C. Eward, Laurie A. Graves Chapter 14: What do we gain from viewing cancer through an eco-evo lens?Jason A. Somarelli and Norman A. Johnson

Notes:

Electronic reproduction. London Available via World Wide Web.

ISBN:

9781003307921

1003307922

9781040027660

1040027660

9781040027684

1040027687

Publisher Number:

99996728123

9781003307921

Access Restriction:

Restricted for use by site license.