Interaction profile for chlorpyrifos, lead, mercury, and methylmercury / Hana R. Pohl, Joan Colman.

Format:

Book

Author/Creator:

Pohl, Hana R., author.

Colman, Joan, author.

Language:

English

Subjects (All):

Chlorpyrifos--Toxicology.

Chlorpyrifos.

Mercury--Toxicology.

Mercury.

Physical Description:

1 online resource (1 PDF file (ix, 93 pages)) : illustrations

Place of Publication:

Atlanta, Ga. : U.S. Department of Health and Human Services, Public Health Service, Agency for Toxic Substances and Disease Registry, 2006.

Summary:

The ATSDR Interaction Profile succinctly characterizes the toxicologic and adverse health effects information for mixtures of hazardous substances. Each peer-reviewed profile identifies and reviews the key literature that describes toxicologic properties of the featured mixtures. The primary purpose of this Interaction Profile for chlorpyrifos, mercury, methylmercury, and lead is to evaluate data on the toxicology of the "whole" mixture and the joint toxic action of the chemicals in the mixture in order to recommend approaches for assessing the potential hazard of this mixture to public health. To this end, the profile evaluates the whole mixture data (if available), focusing on the identification of health effects of concern, adequacy of the data as the basis for a mixture Minimal Risk Level (MRL), and adequacy and relevance of physiologically based pharmacokinetic/pharmacodynamic (PBPK/PD) models for the mixture. The profile also evaluates the evidence for joint toxic action--additivity and interactions--among the mixture components. A weight-of-evidence (WOE) approach is commonly used in these profiles to evaluate the influence of interactions in the overall toxicity of the mixture. The weight-of-evidence evaluations are qualitative in nature, although the Agency for Toxic Substances and Disease Registry (ATSDR) recognizes that observations of toxicological interactions depend greatly one xposure doses and that some interactions appear to have thresholds. Thus, the interactions are evaluated in a qualitative manner to provide a sense of what influence the interactions may have when they do occur. The profile provides environmental health scientists with ATSDR Division of Toxicology's (DT) recommended approaches for the incorporation of the whole mixture data or the concerns for additivity and interactions into an assessment of the potential hazard of this mixture to public health. These approaches can then be used with specific exposure data from hazardous waste sites or other exposure scenarios.

Contents:

PREFACE

CONTRIBUTORS

PEER REVIEW

SUMMARY

LIST OF ACRONYMS, ABBREVIATIONS, AND SYMBOLS

1. Introduction

2. Joint Toxic Action Data for the Mixture of Concern and Component Mixtures

2.1. Mixture of Concern

2.2. Component Mixtures

2.3. Relevance of the Joint Toxic Action Data and Approaches to Public Health

2.4. Recommendations for Data Needs

3. Recommendation for Exposure-Based Assessment of Joint Toxic Action of the Mixture

4. Conclusions

5. References

Appendix A. Background Information for Chlorpyrifos

Appendix B. Background Information for Lead

Appendix C. Background Information for Mercury and Methylmercury

Appendix D. Chemical Structures of Organic Mixture Components.

Notes:

Description based on publisher supplied metadata and other sources.