Interaction profile for persistent chemicals found in breast milk (chlorinated dibenzo-p-dioxins, hexachlorobenzene, p,p'-DDE, methylmercury, and polychlorinated biphenyls) / Hana R. Pohl [and three others].

Format:

Book

Author/Creator:

Pohl, Hana R., author.

Language:

English

Subjects (All):

Dioxins--toxicity.

Dioxins.

Physical Description:

1 online resource (xvii, 209 pages) : illustrations

Other Title:

Interaction profile for persistent chemicals found in breast milk

Place of Publication:

Atlanta, Ga. : U.S. Department of Health and Human Services, Public Health Service, Agency for Toxic Substances and Disease Registry, 2004.

Summary:

The ATSDR Interaction Profile succinctly characterizes the toxicologic and adverse health effects information for mixtures of hazardous substances. Each peer-reviewed profile identifies and reviews the key literature that describes toxicologic properties of the featured mixtures. The primary purpose of this Interaction Profile for chlorinated dibenzo-p-dioxins (CDDs), hexachlorobenzene, p,p'-DDE, methylmercury, and polychlorinated biphenyls (PCBs) is to evaluate data on the toxicology of the "whole" mixture and the joint toxic action of the chemicals in the mixture in order to recommend approaches for assessing the potential hazard of this mixture to public health. To this end, the profile evaluates the whole mixture data (if available), focusing on the identification of health effects of concern, adequacy of the data as the basis for a mixture minimal risk level (MRL), and adequacy and relevance of physiologically-based pharmacokinetic/pharmacodynamic models for the mixture. The profile also evaluates the evidence for joint toxic action--additivity and interactions--among the mixture components.

Contents:

ACKNOWLEDGMENT

PREFACE

CONTRIBUTORS

PEER REVIEW

SUMMARY

LIST OF ACRONYMS, ABBREVIATIONS, AND SYMBOLS

1. Introduction

2. Joint Toxic Action Data for the Mixture of Concern and Component Mixtures

2.1. Mixture of Concern

2.2. Component Mixtures

2.3. Relevance of the Joint Toxic Action Data and Approaches to Public Health

3. Recommendation for Exposure-Based Assessment of Joint Toxic Action of the Mixture

4. Conclusions

5. List of References

APPENDICES

Appendix A. Background Information for Chlorinated Dibenzo-p-Dioxins (CDDs)

Appendix B. Background Information for Hexachlorobenzene

Appendix C. Background Information for p,p'-DDE

Appendix D. Background Information for Methylmercury

Appendix E. Background Information for PCBs

Appendix F. Chemical Structures of Mixture Components.

Notes:

Description based on publisher supplied metadata and other sources.