Interaction profile for persistent chemicals found in fish (chlorinated dibenzo-p-dioxins, hexachlorobenzene, p,p'-DDE, methylmercury, and polychlorinated biphenyls) / Hana R. Pohl [and three others].

Format:

Book

Author/Creator:

Pohl, Hana R., author.

Language:

English

Subjects (All):

Dioxins--toxicity.

Dioxins.

Physical Description:

1 online resource (xix, 213 pages) : illustrations

Other Title:

Interaction profile for persistent chemicals found in fish

Place of Publication:

Atlanta, Ga. : U.S. Department of Health and Human Services, Public Health Service, Agency for Toxic Substances and Disease Registry, 2004.

Summary:

The ATSDR Interaction Profile succinctly characterizes the toxicologic and adverse health effects information for mixtures of hazardous substances. Each peer-reviewed profile identifies and reviews the key literature that describes toxicologic properties of the featured mixtures. Chlorinated dibenzo-p-dioxins (CDDs), hexachlorobenzene, p,p'-DDE (the predominant metabolite of p,p'-DDT), methylmercury, and polychlorinated biphenyls (PCBs) occur with high frequency in water, sediment, and fish from the North American Great Lakes and occur, to varying degrees, in other dietary components including fish from other parts of the world (e.g., the Baltic Sea), human milk, dairy products, and meat. The purposes of this profile are (1) to evaluate data (if available) on health hazards, and their dose-response relationships, from oral exposure to this five-component mixture, (2) to evaluate data on the joint toxic actions of components of this mixture, and (3) to make recommendations for exposure-based assessments of the potential impact of joint toxic action of the mixture on public health.

Contents:

ACKNOWLEDGMENT

PREFACE

CONTRIBUTORS

PEER REVIEW

SUMMARY

LIST OF ACRONYMS, ABBREVIATIONS, AND SYMBOLS

1. Introduction

2. Joint Toxic Action Data for the Mixture of Concern and Component Mixtures

2.1. Mixture of Concern

2.2. Component Mixtures

2.3. Relevance of the Joint Toxic Action Data and Approaches to Public Health

3. Recommendation for Exposure-Based Assessment of Joint Toxic Action of the Mixture

4. Conclusions

5. List of References

APPENDICES

Appendix A. Background Information for Chlorinated Dibenzo-p-Dioxins (CDDs)

Appendix B. Background Information for Hexachlorobenzene

Appendix C. Background Information for p,p'-DDE

Appendix D. Background Information for Methylmercury

Appendix E. Background Information for PCBs

Appendix F. Chemical Structures of Mixture Components.

Notes:

Description based on publisher supplied metadata and other sources.