Provisional peer-reviewed toxicity values for perylene (CASRN 198-55-0) / Laura M. Carlson.

Format:

Book

Author/Creator:

Carlson, Laura M., author.

Language:

English

Subjects (All):

Toxicity Tests--methods.

Toxicity Tests.

Physical Description:

1 online resource (iv, 64 pages) : illustrations

Other Title:

Provisional peer-reviewed toxicity values for perylene

Place of Publication:

Cincinnati, OH : U.S. Environmental Protection Agency, Office of Research and Development, Center for Public Health and Environmental Assessment, 2023.

Summary:

Perylene, CASRN 198-55-0, is a polycyclic aromatic hydrocarbon (PAH) compound that occurs in coal tar and fossil fuels and is found as a byproduct of incomplete combustion (NLM, 2022c). Its structure consists of five fused aromatic rings and can be described as a dinaphthalene. Perylene is preregistered with Europe's Registration, Evaluation, Authorisation, and Restriction of Chemicals (REACH) program (ECHA, 2022) and is listed on the U.S. EPA's Toxic Substances Control Act (TSCA) public inventory (NLM, 2022c; U.S. EPA, 2021). Perylene is used as a fluorescent lipid probe in membrane cytochemistry and in the production of organic semiconductors (NLM, 2022c). Perylene is not produced commercially in the United Sates; it can be produced by the condensation of naphthalene in the presence of mixed Lewis acid and protic acid catalysts or by reaction of phenanthrene with acrolein in anhydrous hydrofluoric acid (NLM, 2022c).

Contents:

AUTHORS, CONTRIBUTORS, AND REVIEWERS

COMMONLY USED ABBREVIATIONS AND ACRONYMS

BACKGROUND

QUALITY ASSURANCE

DISCLAIMERS

QUESTIONS REGARDING PPRTVS

1. INTRODUCTION

2. REVIEW OF POTENTIALLY RELEVANT DATA (NONCANCER AND CANCER)

2.1. HUMAN STUDIES

2.2. ANIMAL STUDIES

2.3. OTHER DATA (SHORT-TERM TESTS, OTHER EXAMINATIONS)

3. DERIVATION OF PROVISIONAL VALUES

3.1. DERIVATION OF PROVISIONAL REFERENCE DOSES

3.2. DERIVATION OF PROVISIONAL REFERENCE CONCENTRATIONS

3.3. SUMMARY OF NONCANCER SCREENING PROVISIONAL REFERENCE VALUES

3.4. CANCER WEIGHT-OF-EVIDENCE DESCRIPTOR

3.5. DERIVATION OF PROVISIONAL CANCER RISK ESTIMATES

APPENDIX A. SCREENING NONCANCER PROVISIONAL VALUES

APPENDIX B. REFERENCES.

Notes:

Description based on publisher supplied metadata and other sources.