Toxicological profile for hexachlorocyclohexane (HCH) / Malcolm Williams.

Format:

Book

Author/Creator:

Williams, Malcolm, author.

Language:

English

Subjects (All):

Environmental Exposure--adverse effects.

Environmental Exposure.

Physical Description:

1 online resource (xi, 350 pages) : illustrations

Other Title:

Toxicological profile for hexachlorocyclohexane

Place of Publication:

Atlanta, Ga. : U.S. Department of Health and Human Services, Agency for Toxic Substances and Disease Registry, 2024.

Summary:

The ATSDR toxicological profile succinctly characterizes the toxicology and adverse health effects information for the toxic substance described therein. Each peer-reviewed profile identifies and reviews the key literature that describes a substance's toxicological properties. Profiles are updated on a periodic basis and released for a public comment period. The toxicological database for HCH includes human observational studies of pesticide workers and the general population and studies of animals exposed by inhalation, oral administration, and dermal application. In general, the studies of pesticide applicators with exposure to I-HCH or technical HCH used qualitative measures of exposure.

Contents:

DISCLAIMER

FOREWORD

VERSION HISTORY

CONTRIBUTORS & REVIEWERS

CHAPTER 1. RELEVANCE TO PUBLIC HEALTH

1.1. OVERVIEW AND U.S. EXPOSURES

1.2. SUMMARY OF HEALTH EFFECTS

1.3. MINIMAL RISK LEVELS (MRLs)

CHAPTER 2. HEALTH EFFECTS

2.1. INTRODUCTION

2.2. DEATH

2.3. BODY WEIGHT

2.4. RESPIRATORY

2.5. CARDIOVASCULAR

2.6. GASTROINTESTINAL

2.7. HEMATOLOGICAL

2.8. MUSCULOSKELETAL

2.9. HEPATIC

2.10. RENAL

2.11. DERMAL

2.12. OCULAR

2.13. ENDOCRINE

2.14. IMMUNOLOGICAL

2.15. NEUROLOGICAL

2.16. REPRODUCTIVE

2.17. DEVELOPMENTAL

2.18. OTHER NONCANCER

2.19. CANCER

2.20. GENOTOXICITY

CHAPTER 3. TOXICOKINETICS, SUSCEPTIBLE POPULATIONS, BIOMARKERS, CHEMICAL INTERACTIONS

3.1. TOXICOKINETICS

3.2. CHILDREN AND OTHER POPULATIONS THAT ARE UNUSUALLY SUSCEPTIBLE

3.3. BIOMARKERS OF EXPOSURE AND EFFECT

3.4. INTERACTIONS WITH OTHER CHEMICALS

CHAPTER 4. CHEMICAL AND PHYSICAL INFORMATION

4.1. CHEMICAL IDENTITY

4.2. PHYSICAL AND CHEMICAL PROPERTIES

CHAPTER 5. POTENTIAL FOR HUMAN EXPOSURE

5.1. OVERVIEW

5.2. PRODUCTION, IMPORT/EXPORT, USE, AND DISPOSAL

5.3. RELEASES TO THE ENVIRONMENT

5.4. ENVIRONMENTAL FATE

5.5. LEVELS IN THE ENVIRONMENT

5.6. GENERAL POPULATION EXPOSURE

5.7. POPULATIONS WITH POTENTIALLY HIGH EXPOSURES

CHAPTER 6. ADEQUACY OF THE DATABASE

6.1. EXISTING INFORMATION ON HEALTH EFFECTS

6.2. IDENTIFICATION OF DATA NEEDS

6.3. ONGOING STUDIES

CHAPTER 7. REGULATIONS AND GUIDELINES

CHAPTER 8. REFERENCES

APPENDICES

APPENDIX A. ATSDR MINIMAL RISK LEVEL WORKSHEETS

APPENDIX B. LITERATURE SEARCH FRAMEWORK FOR HCH

APPENDIX C. FRAMEWORK FOR ATSDR'S SYSTEMATIC REVIEW OF HEALTH EFFECTS DATA FOR HCH

APPENDIX D. USER'S GUIDE

APPENDIX E. QUICK REFERENCE FOR HEALTH CARE PROVIDERS

APPENDIX F. GLOSSARY

APPENDIX G. ACRONYMS, ABBREVIATIONS, AND SYMBOLS.

Notes:

Description based on publisher supplied metadata and other sources.