Drug Targets for Plasmodium Falciparum: Historic to Future Perspectives / by Mohammed Tarique.

Format:

Book

Author/Creator:

Tarique, Mohammed.

Series:

Biomedical and Life Sciences Series

Language:

English

Subjects (All):

Parasitology.

Proteins.

Diseases--Causes and theories of causation.

Diseases.

Pharmacology.

Pathogenesis.

Local Subjects:

Parasitology.

Proteins.

Pathogenesis.

Pharmacology.

Physical Description:

1 online resource (205 pages)

Edition:

1st ed. 2024.

Place of Publication:

Singapore : Springer Nature Singapore : Imprint: Springer, 2024.

Summary:

This book offers a comprehensive exploration of malaria, a life-threatening disease affecting millions globally, with a focus on the parasitic organisms of the genus Plasmodium that cause it. It discusses the challenges posed by the disease, especially in economically developing regions, and delves into the biology and pathophysiology of the Plasmodium species, including their genetic flexibility and resistance to treatments. Special attention is given to P. falciparum, the most dangerous of these parasites, detailing its complex life cycle, interaction with human hosts, and the severe clinical manifestations it can induce. The book further explores the global health concern of antimalarial drug resistance, highlighting the WHO's efforts in combating the disease and the necessity for novel treatments. Innovative research directions, such as targeting the unique organelles of Plasmodium like the apicoplast and employing proteasome inhibitors, are thoroughly examined as potential strategies in the development of new antimalarial drugs. Additionally, it addresses the critical role of the hemoglobin digestion process in the parasite's lifecycle, presenting it as a promising target for therapeutic intervention. This work is an essential resource for researchers, clinicians, and policymakers involved in malaria control and drug development, providing insights into the current challenges and future directions in the fight against this endemic disease.

Contents:

Chapter 1. Introduction: An overview of Malaria and Plasmodium

Chapter 2. Pathogenesis of Plasmodium falciparum

Chapter 3. Antimalarial Drugs and drug resistance

Chapter 4. Metabolic pathways of Enzymes: Therapeutic targets and prospects for Innovative antimalarial drugs

Chapter 5. Targeting apicoplasts in Plasmodium falciparum, origin and pathways

Chapter 6. Proteases and protein kinases as potential drug target

Chapter 7. Plasmodium falciparum: Transporter and Drug Target

Chapter 8. Enzymes of isoprenoid biosynthesis and control of malarial parasite plasmodium falciparum

Chapter 9.Ubiquitin-Proteasome system as a potential drug target for Malaria

Chapter 10.Food Vacuole as a Drug Target.

Notes:

Description based on publisher supplied metadata and other sources.

ISBN:

9789811944840

OCLC:

1443942412