Treatment of Breast Cancer with Natural Products.

Format:

Book

Author/Creator:

Mishra, Yachana.

Contributor:

Mishra, Vijay.

Language:

English

Subjects (All):

Natural products.

Cancer.

Physical Description:

1 online resource (266 pages)

Edition:

1st ed.

Place of Publication:

San Diego : Elsevier Science & Technology, 2024.

Summary:

The book 'Treatment of Breast Cancer with Natural Products' by Yachana Mishra and Vijay Mishra explores the use of natural products in the treatment of breast cancer. It provides an extensive overview of various natural compounds such as curcumin, paclitaxel, quercetin, resveratrol, sulforaphane, allicin, berberine, and vinca alkaloids, detailing their anticancer mechanisms, delivery systems, and clinical trials. The book aims to serve as a comprehensive resource for clinicians, biochemists, and medical students interested in alternative treatments for breast cancer. It discusses the potential benefits and limitations of natural products as therapeutic agents, emphasizing the need for further research in this area. The authors intend for the book to stimulate interest in non-toxic treatment alternatives and to inform both academic and clinical audiences about advancements in breast cancer management. Generated by AI.

Contents:

Front Cover

Treatment of Breast Cancer with Natural Products

Treatment of Breast Cancer with Natural ProductsYachana MishraSchool of Bioengineering and Biosciences, Lovely Professional ...

Dedication

Contents

About the authors

Preface

Acknowledgments

One - Breast cancer: An insight

1. Introduction

2. Epidemiology of breast cancer

3. Etiology of breast cancer

4. Risk factors for breast cancer

4.1 Sex, age, and blood group

4.2 Degree of economic development

4.3 Hormonal status

4.4 Reproductive risk factors

4.5 Genetic factors

4.6 Mild breast changes

4.7 Ionizing radiations

4.8 Alcohol consumption and nicotinism

4.9 Diet and obesity

5. Types of breast cancer

5.1 Noninvasive breast cancer

5.1.1 Ductal carcinoma in situ

5.1.2 Lobular carcinoma in situ

5.2 Invasive breast cancer

5.2.1 Infiltrating lobular carcinoma

5.2.2 Infiltrating ductal carcinoma

5.2.3 Medullary carcinoma

5.2.4 Mucinous carcinoma

5.2.5 Tubular carcinoma

5.2.6 Inflammatory breast cancer

5.2.7 Paget's disease of breast

5.2.8 Phyllodes tumor

5.2.9 Triple-negative breast cancer

6. Breast cancer screening

6.1 Mammography

6.2 Magnetic resonance imaging

6.3 Ultrasound

6.4 Dynamic contrast-enhanced MRI

6.5 Magnetic resonance spectroscopy

6.6 Breast-specific gamma imaging

7. Available approaches to control breast cancer

7.1 Molecular testing

7.2 Liquid biopsy

7.3 Genetic testing

7.4 Artificial intelligence

8. Treatments for breast cancer

8.1 Local treatment

8.1.1 Surgery

8.1.2 Radiation therapy

8.2 Systemic treatment

8.2.1 Hormonal therapy.

8.2.2 Chemotherapy

8.2.3 Biological therapy

9. Drug delivery systems in the treatment of breast cancer

9.1 Systemic drug delivery approaches

9.1.1 Organic drug delivery approaches

9.1.1.1 Liposomes

9.1.1.2 Micelles

9.1.1.3 Dendrimers

9.1.1.4 Polymers

9.1.2 Inorganic drug delivery approaches

9.1.2.1 Quantum dots

9.1.2.2 Gold nanoparticles

9.2 Localized drug delivery approaches

9.2.1 Hydrogels

9.2.2 Nanofibers

10. Drug targeting approaches in the treatment of breast cancer

10.1 Passive targeting

10.2 Active targeting

10.3 Targeted therapies in breast cancer treatment

11. Conclusion and future perspectives

References

Two - Curcumin in breast cancer treatment

2. Curcumin

2.1 History

2.2 Phytochemistry of curcumin

2.3 Metabolism of curcumin

2.4 Isolation and identification of curcumin

3. Physicochemical properties of curcumin

4. Anticancer action mechanism of curcumin

4.1 Inhibiting the cancer cell proliferation

4.2 Inhibition of invasion and migration

4.3 Inducing cell apoptosis and autophagy

4.4 Effect of curcumin on molecular signaling pathways

4.4.1 P13k/Akt/mTOR pathway

4.4.2 JAK/STAT3 pathway

4.4.3 ERK/MAPK pathway

4.4.4 NF-κB pathway

4.4.5 P53 pathway

4.4.6 Wnt/β-catenin signaling pathway

5. Reported studies of curcumin

6. Delivery systems of curcumin

7. Toxicity profile of curcumin

7.1 In vitro cellular toxicity test and antitumor activity

8. Clinical trials of curcumin

9. Conclusion and future perspectives

Three - Paclitaxel in breast cancer treatment

2. Paclitaxel

2.2 Chemistry and metabolization

2.3 Methods of preparation

2.3.1 Old extraction method

2.3.2 New extraction method

2.3.3 Semisynthetic methods.

2.3.3.1 Cell culture-based method

2.3.3.2 Holton's method

3. Physical and chemical characteristics of paclitaxel

4. Anticancer action mechanism of paclitaxel

4.1 Pharmacological resistance mechanism of paclitaxel

4.1.1 RNF 8/TWIST/ROR 1 axis

4.1.2 TLR4-dependent resistance

4.1.3 BRCA1-IRIS

4.1.4 Nf-κB pathway

4.2 Induction of apoptosis and autophagy

5. Delivery systems of paclitaxel

5.1 Liposomes

5.2 Micelles

5.3 Nanoparticles

5.3.1 Solid-lipid nanoparticles

5.3.2 Polymeric nanoparticles

5.3.2.1 Chitosan

5.3.2.2 Poly lactic-co-glycolic acid (PLGA)

5.4 Prodrug approach

5.4.1 Macromolecules-based prodrugs

5.4.2 Targeting prodrugs

5.5 Emulsions

5.6 Hydrogels

5.7 Implants

6. Toxicity profile of paclitaxel

6.1 Hypersensitivity

6.2 Neurotoxicity

6.3 Hematological toxicity

6.4 Cardiotoxicity

7. Conclusion and future aspects

Four - Quercetin in breast cancer treatment

2. Quercetin

2.1 Chemical structure and phytochemistry

2.2 Metabolism and pharmacokinetics

3. Physicochemical properties of quercetin

4. Anticancer mechanism of action of quercetin

4.1 Inhibition of metastasis

4.2 Effect on cell proliferation

4.3 Wnt/β-catenin pathway

4.4 PI3K/Akt pathway

4.5 JAK/STAT/MAPK pathway

4.6 p53, NF-κB, and apoptotic pathway

4.7 Autophagy pathway

5. Reported studies of quercetin

6. Delivery systems of quercetin

7. Toxicity profile of quercetin

8. Clinical trials on quercetin

9. Patents on quercetin

10. Conclusion and future prospects

Five - Resveratrol in breast cancer treatment

2. Resveratrol

2.1 Historical background

2.2 Phytochemistry and chemical structure

2.3 Sources and absorption of resveratrol

2.4 Metabolism of resveratrol.

3. Physiochemical properties of resveratrol

4. Anticancer action mechanism of resveratrol

4.1 Resveratrol as a phytoestrogen

4.2 Inhibition of aromatase

4.3 Induction of apoptosis, autophagy, and cell cycle arrest

4.4 Effects on Nrf2/ARE pathway

4.5 Effects on NF-κB/STAT3/MAPK pathways

5. Reported studies of resveratrol

6. Delivery systems of resveratrol

7. Toxicity profile of resveratrol

8. Clinical trials on resveratrol

Six - Sulforaphane in breast cancer treatment

2. Sulforaphane

2.2 Phytochemistry

2.3 Metabolism and absorption of sulforaphane

3. Physical and chemical properties of sulforaphane

4. Anticancer action mechanism of sulforaphane

4.1 NRF-2 mediated elevation of antioxidant defense

4.2 Induction of mitochondria-mediated apoptosis

4.3 Promotes autophagy

4.4 Induction of cell cycle arrest

5. Reported studies of sulforaphane

6. Hydrogel delivery systems of sulforaphane

7. Toxicity profile of sulforaphane

8. Clinical trials on sulforaphane

9. Patents on sulforaphane

10. Conclusion and future directions

Seven - Epigallocatechin-3-gallate in breast cancer treatment

2. Epigallocatechin

2.2 Chemical structure and phytochemistry

2.3 Metabolism

2.4 Absorption

3. Basic physicochemical properties of epigallocatechin

4. Anticancer action mechanism of epigallocatechin

4.1 Preventing DNA damage and ROS elevation brought on by carcinogens

4.2 Inhibition of DNA methylation

4.3 Inhibition of tumor angiogenesis

4.4 Interacting with target proteins

4.5 Antimetastasis of breast cancer cells

4.6 Regulation of cell signaling pathways

4.6.1 PI3K/Akt/mTOR pathway

4.6.2 ERK and 67-LR pathway.

4.6.3 EGFR and STAT3 pathway

5. Reported studies of epigallocatechin

6. Delivery systems of epigallocatechin

7. Toxicity profile of epigallocatechin

8. Clinical trials on epigallocatechin

9. Patents on epigallocatechin

10. Conclusion and future perspectives

eight - Allicin in breast cancer treatment

2. Allicin

2.3 Absorption

2.4 Metabolism

3. Basic physicochemical properties of allicin

4. Anticancer action mechanism of allicin

4.1 Induction of apoptosis and autophagy

4.2 Inhibition of metastasis

4.3 AMPK/TSC2 pathway

4.4 p53 pathway

5. Reported studies of allicin

6. Delivery systems of allicin

7. Toxicity profile of allicin

8. Conclusion and future perspectives

Nine - Berberine in breast cancer treatment

2. Berberine

3. Basic physicochemical properties of berberine

4. Anticancer mechanism of berberine

4.1 Induce cell cycle arrest

4.2 Modulates autophagy

4.3 Modulates expression of miRNA

4.4 Effects on Akt/Nrf2 signaling pathway

4.5 Effects on MAPK/NF-κB signaling pathway

4.6 mTOR/JAK/STAT pathway

5. Reported studies of berberine

6. Delivery systems of berberine

7. Toxicity profile of berberine

8. Clinical trials on berberine

9. Patents on berberine

Ten - Vinca alkaloids in breast cancer treatment

2. Vinca alkaloids

2.1 Types of vinca alkaloids and their historical background

2.1.1 Vinblastine

2.1.2 Vincristine

2.1.3 Vindesine

2.1.4 Vinorelbine

2.1.5 Vinflunine

2.2 Chemical structure and phytochemistry.

2.3 Metabolism of vinca alkaloids.

Notes:

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Part of the metadata in this record was created by AI, based on the text of the resource.

ISBN:

9780443299148

OCLC:

1439598871