The Science and Business of Drug Discovery : Demystifying the Jargon / by Edward D. Zanders.

Format:

Book

Author/Creator:

Zanders, Edward D., author.

Language:

English

Subjects (All):

Pharmacology.

Pharmacovigilance.

Pharmaceutical chemistry.

Chemistry, Physical and theoretical.

Biotechnology.

Drug Safety and Pharmacovigilance.

Pharmaceutics.

Theoretical Chemistry.

Local Subjects:

Pharmacology.

Drug Safety and Pharmacovigilance.

Pharmaceutics.

Theoretical Chemistry.

Biotechnology.

Physical Description:

1 online resource (XVII, 402 p. 102 illus., 20 illus. in color.)

Edition:

2nd ed. 2020.

Place of Publication:

Cham : Springer International Publishing : Imprint: Springer, 2020.

Summary:

The Science and Business of Drug Discovery is written for those who want to learn about the biopharmaceutical industry and its products whatever their level of technical knowledge. Its aim is to demystify the jargon used in drug development, but in a way that avoids over simplification and the resulting loss of key information. Each of the twenty chapters is illustrated with figures and tables which clarify some of the more technical points being made. Also included is a drug discovery case history which draws the relevant material together into a single chapter. In recognizing that it is difficult to navigate through the many external resources dealing with drug development, the book has been written to guide the reader towards the most appropriate information sources, including those listed in the two appendices. The following topics are covered: Different types of drugs: from small molecules to stem cells Background to chemistry ofsmall and large molecules Historical background to drug discovery, pharmacology and biotechnology The drug discovery pipeline: from target discovery to marketed medicine Commercial aspects of drug discovery Challenges to the biopharmaceutical industry and its responses Material of specific interest to technology transfer executives, recruiters and pharmaceutical translators .

Contents:

Introduction

PART 1: How Drugs are Discovered and Developed in the Pharmaceutical Industry

Introduction to Drugs and Drug Targets

Background to chemistry of small and large molecules

Laying the foundations- Drug discovery from antiquity to the twenty first century

Part II-The drug development pipeline – discovery to testing in humans

Drug discovery pipeline overview

Target discovery

Medicinal chemistry

Biotherapeutics

Screening for hits

Process chemistry and formulation

Preclinical development

Part III-The drug development pipeline – clinical trials to marketing authorisation

Clinical trials

Regulatory affairs and marketing approval

Diagnostics and personalized medicine

Putting it All Together: a drug development case history

Part IV- The Global Pharmaceuticals Business

Commercial aspects of drug development

Challenges and responses

Part V - Professional Interactions with the Drug Discovery Industry.-Professional Interactions with the Drug Discovery Industry: Technology Transfer Executives

Recruitment Executives

Pharmaceutical translators and Interpreters.

Notes:

Includes bibliographical references and index.

ISBN:

9783030578145

3030578143