Circadian Pharmacokinetics / edited by Baojian Wu, Danyi Lu, Dong Dong.

Format:

Book

Contributor:

Wu, Baojian, editor.

Lu, Danyi, editor.

Dong, Dong, editor.

Language:

English

Subjects (All):

Pharmacology.

Pharmacy.

Medical sciences.

Drug development.

Preclinical Research.

Local Subjects:

Pharmacology.

Pharmacy.

Preclinical Research.

Physical Description:

1 online resource (VII, 253 p. 59 illus., 46 illus. in color.)

Edition:

1st ed. 2020.

Place of Publication:

Singapore : Springer Nature Singapore : Imprint: Springer, 2020.

Summary:

This book summarizes the recent advances for the understanding of circadian clock system in the regulation of drug metabolism and pharmacokinetics. Basic knowledge in the field of circadian clock and pharmacokinetics are systemically introduced to make it easier for readers to understand the entire book's contents. The rhythmic expression of DMEs (drug-metabolizing enzymes) and transporters are summarized, and the underlying mechanisms thereof (i.e., regulation by circadian oscillators) are discussed. Typically, evidence for the DME- and transporter-mediated chronopharmacokinetics, chronotoxicity and chronoefficacy are highlighted in this book.

Contents:

Chapter 1. Introduction to mammalian circadian clock system

Chapter 2. Introduction to pharmacokinetics

Chapter 3. Circadian clock and metabolic diseases

Chapter 4. Circadian clock and CYP metabolism

Chapter 5. Circadian clock and non-CYP phase I metabolism

Chapter 6. Circadian clock and phase II metabolism

Chapter 7. Circadian clock and uptake transporters

Chapter 8. Circadian clock and efflux transporters

Chapter 9. Role of pharmacokinetics in chronotherapeutics

Chapter 10. Role of non-pharmacokinetic factors in chronoefficacy.

ISBN:

981-15-8807-4