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Tuning autophagy-inducing activity and toxicity for lanthanide nanocrystals / Yunjiao Zhang.
Springer eBooks EBA - Springer Chemistry and Material Science Collection 2022 Available online
View online- Format:
- Book
- Author/Creator:
- Zhang, Yunjiao, author.
- Series:
- Springer theses.
- Springer theses
- Language:
- English
- Subjects (All):
- Nanocrystals.
- Physical Description:
- 1 online resource (169 pages)
- Place of Publication:
- Gateway East, Singapore : Springer, [2022]
- Summary:
- This thesis presents a simple, yet highly effective surface engineering solution that uses non-covalent binding peptides to control the autophagy-inducing activity of nanomaterials and nanodevices. The author presents RE-1, a short synthetic peptide that sequence-specifically binds to lanthanide (LN) oxide and upconversion nanocrystals with high affinity, which was discovered using an innovative phage display approach. RE-1 effectively inhibits the autophagy-inducing activity and toxicity of these nanocrystals by forming a stable coating layer on the surface of the nanoparticles, and by reducing their sedimentation and cell interaction. RE- 1 and its variants provide a versatile tool for tuning cell interactions in order to achieve the desired level of autophagic response and are useful for the various diagnostic and therapeutic applications of LN-based nanomaterials and nanodevices.
- Notes:
- Description based on print version record.
- Other Format:
- Print version: Zhang, Yunjiao Tuning Autophagy-Inducing Activity and Toxicity for Lanthanide Nanocrystals
- ISBN:
- 981-16-8166-X
- 981-16-8165-1
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