Advanced therapeutics in pain medicine / edited by Sahar Swidan, Matthew Bennett.

Format:

Book

Contributor:

Bennett, Matthew, editor.

Swidan, Sahar, editor.

Language:

English

Subjects (All):

Pain--Treatment.

Pain.

Physical Description:

1 online resource (407 pages)

Edition:

1st ed.

Place of Publication:

Boca Raton, Florida ; London, England ; New York : CRC Press, [2021]

Summary:

"Chronic pain places a tremendous burden on both the patient and the healthcare system. The use of opioids to address pain has resulted in negative impacts. As practitioners work to undo the current opioid crisis, options to manage pain need a new approach. Advanced Therapeutics in Pain Medicine offers pioneering approaches to this intransigent problem providing a functional medicine approach toward treating pain. This book is dedicated to the advancement of non-opioid therapeutic options that offer real progress in reaching a future of better pain management. With an emphasis on pathophysiology, chapters review various types of pain and propose comprehensive treatment plans. These include manual therapies, novel pharmacologic and plant-based approaches, hormonal effects on pain pathways, as well as psychological and lifestyle interventions"-- Provided by publisher.

Contents:

Cover

Half Title

Title Page

Copyright Page

Table of Contents

Preface

Editors

Contributors

Chapter 1 Physiology of the Pain System

Peripheral System

Axons

Central System

Spinal Cord

Dorsal Horn Excitability

Supraspinal Modulation

Spinothalamic Tract

Brain Considerations

Other Considerations

References

Chapter 2 Neuro-Endocrine-Immune Dysfunction in the Chronic Pain Patient

Peripheral Sensitization

Mast Cells

Endocrine and Inflammation

Autonomic Nervous System and Inflammation

More on Peripheral Sensitization

DRG

Central Sensitization

Dorsal Horn Modulation

Brain

Endocrine System

Mitochondria

Leptin and Ghrelin

Conclusion

Chapter 3 The Opioid Epidemic

Opioid Overview

Opioid Failure

NMDA Pathway

Non-NMDR Pathways

Genetic Implications

Glial Cells

Hyperalgesia

Endocrine Disruption

Autonomic Nervous System

Chapter 4 Endogenous Cannabinoid Receptors and Medical Cannabis

Historical Considerations and Clinical Precedent

Maintaining Physiologic Balances

The Roles of Receptors and Their Ligands

A Master Regulatory System's Mechanism of Action

The Ubiquitous Endocannabinoid System

Plant-Derived Molecules Engage Endogenous Receptors

The Effects of Bioactive Cannabis Plant Chemicals Lead to the Discovery of Receptors and Endocannabinoids

Cannabis Modulates Opiates as Endocannabinoids Modulate Endorphins

Chemical Complexity of the Cannabis Plant

Δ-9 Tetrahydrocannabinol (THC) and Cannabidiol (CBD)

FDA Approval of CBD as a Medicine

Additional Bioactive Chemical Components in Cannabis

Research: Evidenced-Based Data vs. Anecdotal Experiences

Institutes of Medicine (1999)

National Academies of Sciences, Engineering, and Medicine (2017).

Education: Clinical Rationale to Cannabinoids Used as Medicine

A Concept Model Describing the Roles of Endocannabinoids

Clinical Considerations of Cannabinoid Medicines

Dosing Guidance

Paradoxical Dose-Dependent Effects on Pain

Routes of Administration

Risks and Contraindications

Contaminants and Testing

Contemporary Cannabis and Its Medicalization

Legal Status and Accreditable Practice Standards

Future Developments

The Contemporary Clinician's Responsible Role

Chapter 5 Sex Hormones and Pain Control

Introduction

Sex Hormones in Women

Sex Hormones in Males

Pregnenolone in Women and Men

Adrenal Hormones in Women and Men

The Effects of Pain on Sex Hormones

Hormones and Pain Control

Opioid Suppression of Hormones

Chapter 6 Managing Pain in the Presence of Autoimmune Disease

Etiology of AD and Immune System Dysregulation

Genetics and Terrain Plus Environmental Triggers

Losing the Immune System Set Point

Diagnostic Testing

Bloodwork

Bloodwork: Interpretation

Blood Work: Treatment

Salivary Cortisol

Salivary Cortisol: Testing

Salivary Cortisol: Interpretation

Salivary Cortisol: Treatment

Diagnostic Stool Analysis

Digestive Stool Analysis: Testing

Digestive Stool Analysis: Interpretation

Digestive Stool Analysis: Treatment

Provocative Heavy Metal Test

Provocative Heavy Metal: Testing

Heavy Metal: Assessment

Heavy Metal: Treatment

Food Sensitivity Test

Food Sensitivity Test: Testing

Food Sensitivity Test: Assessment

Food Sensitivity Test: Treatment

Treatment Based on Empirical Knowledge Rather Than Lab Results

Case Studies

Potential Testing Limitations

Chapter 7 Fibromyalgia: A Comprehensive Perspective

What Is Fibromyalgia?.

Microbiome Composition in Patients with Fibromyalgia

Current Treatments for Fibromyalgia

Medication Therapies

Medications and Experimental Agents under Study for Fibromyalgia

Low-Dose Naltrexone

Dopamine Agonists

Ambroxol

NMDAR Inhibitors

Antiviral/Cyclooxygenase Inhibitor Combination (IMC-1)

Cannabinoids

Herbals and Supplements

5-Hydroxytryptophan (5-HTP)

S-Adenosyl-l-Methionine (SAMe)

St. John's Wort

Magnesium

Coenzyme Q10

Melatonin

Panax Ginseng

Ribose

Vitamin D

Acetyl l-Carnitine

Capsaicin

Turmeric

Valerian, Chamomile, and Passion Flower

Adaptogens

Non-Drug Therapies

Mind-Body Practices

Chapter 8 A Functional Approach to Gynecologic Pain: Integrative Gynecology for the Non-Gynecologist

Examination and Imaging

Types of Pain

Menstrual

Pain during the Period: Dysmenorrhea

The Ovarian Cyst

Non-Menstrual Pain

Infectious Causes

Vulvar Pain Syndrome

Chapter 9 Headache Disorders

Migraine

Diagnosis

Pathogenesis

Migraine Treatment

New Thoughts on Treatment

New Developments in Migraine Treatment

Role of Opiates in Migraine Treatment

Migraine and the Emergency Department

Trigeminal Autonomic Cephalalgias

Cluster Headache

Treatment

New Cluster Headache Therapies

Indomethacin-Responsive TACS

Chronic Paroxysmal Hemicrania

Hemicrania Continua

Indomethacin Treatment

Other Potential Non-Indomethacin Treatments78

SUNCT Syndrome

Other Less Common Primary Headache Syndromes

Primary Exercise Headache1,82

Primary Cough Headache1,82

Primary Headache Associated with Sexual Activity1,82

New Daily Persistent Headache

Secondary Disorders Mimicking NDPH

Key Points in Regard to NDPH

Summary

References.

Chapter 10 Biotensegrity: Advancing Pain Diagnosis and Treatment by Rethinking Anatomy and Biomechanics

Myofascial Pain as an Introduction to Understanding Chronic Pain and Sports Injury

Not All Feedback and Control Are Neurologic

The Case of a Bodybuilder with Degenerative Arthrosis

An Advantage of Dynamic Ultrasonography

Tensegrity: The Tension Is the Frame

Biotensegrity-Based Anatomy and Biomechanics: A Summary

Fascia as a Body-Wide Signaling Mechanism

Clinical Application of Biotensegrity Principles in Pain Medicine: A Summary

Biotensegrity-Informed History

Biotensegrity-Informed Physical Exam

The False Concept of Ligaments as the Only Controllers of PROM

Biotensegrity-Informed Treatment

Restoration of Tensional Integrity: Clinical and Tissue Improvements 3 Months Post-Procedure

Chapter 11 Myofascial Trigger Points, Sensitization, and Chronic Musculoskeletal Pain: Evaluation and Management

Origin and History of MPS

Chronic Musculoskeletal Pain and Sensitization: Implications for Evaluation and Treatments

Aims and Objectives

MPS, Sensitization, and Viscerosomatic Interactions

The Role of the Limbic System

Possible Physiological Mechanisms

Clinical Evaluation of the MTrP and Sensitized Segments

Principles and Methods of Treatment

Treating the MTrP

Beyond the MTrP: Spinal Segmental Sensitization

Perpetuating Factors of MPS

A Case Scenario

Chapter 12 Mycotoxins and Tick-Borne Disease: Increasingly Common Causes of Unexplained Chronic Pain

Lyme Disease

History

Epidemiology

Pain as a Clinical Presentation

Molecular Mechanisms of Pain in Lyme Disease

Diagnosis of Lyme Disease

Antibiotic Treatment of Lyme Disease

Herbal Treatment of Lyme Disease.

A Note on Co-Infections

Mycotoxin Illness

Molecular Mechanisms of Pain in Mycotoxin Illness

Environmental Diagnosis

Patient Diagnosis

Treatment of Mycotoxin Illness

Pain Management in Environmentally Acquired Illness

Chapter 13 Regenerative Medicine in Pain Management

Mesenchymal Stem Cells

Bone Marrow-Derived Stem Cells

Adipose-Derived Stem Cells

MSCs in Pain Management

Neuropathic Pain

Discogenic Pain

Osteoarthritis or Inflammatory Pain

Bone Marrow-Derived Stem Cell Studies in OA

Adipose-Derived Stem Cell Studies in OA

Allogeneic-Derived Stem Cells

Cancer Pain

Opioid Tolerance and Opioid-Induced Hyperalgesia

Extracellular Vesicles

Chapter 14 Adenine Dinucleotide: Past, Present, and Future

Historical Perspective on NAD+

What Is the Role of NAD+ in the Body?

Current Clinical Applications of Intravenous NAD+

Basic Research into the Mechanisms of NAD+ Effectiveness

The Effect of Alcohol on NAD+ Levels and Markers for Inflammation and Oxidative Stress

NAD+'s Effectiveness at Reducing Inflammation and Oxidative Stress Levels in Addiction Patients

Intravenous NAD+ Infusion Reduces a Second Marker for Inflammation and Oxidative Stress in Addiction Patients

Intravenous BR+NADTM Infusions Increase the NAD+/NADH Ratio in Alcohol Abuse Patients

Intravenous BR+NADTM Infusions Increase the NAD+/NADH Ratio in Patients Addicted to Opiates

Establishing Baseline NAD+ Levels

Additional NAD Research, Inc., Partnership Studies Underway or Planned

Chapter 15 Ketamine Use in Pain Management

Background

Mechanism of Action

Pharmacokinetics

Pain Management with Ketamine

Dosages and Routes of Administration

Intranasal

Intravenous

Parenteral Ketamine.

Intranasal Ketamine.

Notes:

Description based on print version record.

ISBN:

0-429-50489-6

0-429-99826-0

9780429504891

OCLC:

1206395913