An Introduction to Mycosporine-Like Amino Acids / Hakuto Kageyama.

Format:

Book

Author/Creator:

Kageyama, Hakuto, author.

Language:

English

Subjects (All):

Mycosporine-like amino acids.

Amino acids--Biotechnology.

Amino acids.

Physical Description:

1 online resource (165 pages)

Edition:

First edition.

Place of Publication:

Singapore : Bentham Books, [2023]

Summary:

Mycosporine-like amino acids (MAAs), have the property of absorbing ultraviolet rays, and are widely used as active ingredients in cosmetics such as sunscreens. They also have many bioactive properties that make them an attractive ingredient for pharmaceuticals and functional food. This book summarizes information about the molecular structures, activities and applications of mycosporine-like amino acids (MAAs). It aims to be an introductory book for undergraduate and graduate students in applied sciences, or as a handbook for researchers in pharmaceutical chemistry and cosmetics. Key features - 11 structured chapters covering the biochemistry of MAAs - Introduces readers to biochemical and synthetic pathways of MAAs - Presents information on many bioactive properties of MAAs including helioprotective, anti-inflammatory, antioxidant and anti-collagenase effects - Simple, clear explanations for learners - Academic and scholarly references for advanced readers - Illustrated appendices.

Contents:

Cover

Title

Copyright

End User License Agreement

Contents

Foreword

Preface

Mycosporine-like Amino Acids and their Biomolecular Properties

INTRODUCTION

MOLECULAR STRUCTURES OF MAAS

Basic Chemical Structure

Resonance Hybrid Structures

Factors that Affect the Molecular Structures of MAAs

DATABASE OF MAAS

CONCLUDING REMARKS

LIST OF ABBREVIATIONS

CONSENT FOR PUBLICATION

CONFLICT OF INTEREST

ACKNOWLEDGEMENTS

REFERENCES

Distribution of MAAs

MACROALGAE

CYANOBACTERIA

Cyanobacteria in which MAA Accumulation is Induced by UV Irradiation

Cyanobacteria in which MAA Accumulation is Induced by Salt and Osmotic Stress

Cyanobacteria in which MAA Accumulation is Induced by Temperature Changes

Cyanobacteria of the Genus Nostoc that are Resistant to Drought

Biosynthetic Pathways of MAAs and their Regulatory Mechanisms

INTRODCUTION

Biosynthetic Pathways of MAAs

Biosynthetic Pathway of 4-deoxygadusol, A Precursor Compound of MAAs

Biosynthesis of 4-DG from the Shikimate Pathway

Discovery of DHQS and O-MT by Genome Mining

Biosynthesis of 4-DG from the Pentose Phosphate Pathway

Biosynthetic Pathway of MAAs Utilizing 4-DG as a Precursor

Gene Clusters for Biosynthesis of MAAs in Cyanobacteria

MAA Biosynthetic Genes in Species other than Cyanobacteria

MAA Biosynthetic Genes as Gene Resources

Substrate Specificity of NRPS/D-Ala-D-Ala Ligase

REGURATORY MECHANISMS OF MAA BIOSYNTHETIC PATHWAYS

UV Irradiation Stress

Salt Stress and Osmotic Stress

Other Abiotic Factors

Nutrient Concentration

Temperature

Far-red Light

Bottleneck Factors in MAA Synthesis

Supply of Precursors of MAAs.

Supply of Amino Acids

LOCALIZATION OF MAAS

Analytical and Preparative Methods for MAAs

Analysis of Maas and their Molecular Structures

HPLC Analysis of MAAs

Methods to Determine the Molecular Structures of MAAs

Measurement of Absorption Maximum Wavelength of MAA

Determination of Molecular Weight of MAA Molecules

Identification of Amino Acid Residues Contained in MAA Structures by Amino Acid Analysis

Characterization of the Molecular Structure of MAA by NMR Analysis

Shinorine

Porphyra-334

Mycosporine-2-glycine

NMR Conditions

Examples of Studies that Determined the Molecular Structures of MAAs

PREPARATION AND PRODUCTION OF MAAS

Preparation of MAAs

Extractions of MAAs

Chromatographic Separation

Practical Example

Production of MAAs

Biological Activities of MAAs and their Applications 1: UV-protective Activity of MAAs and their Application as Sunscreens

UV-A

Characteristics of UV-A and its Effect on the Skin

UV-B

Characteristics of UV-B and its Effect on the Skin

HELIOGUARD 365

About Helioguard 365

Properties and Activities of Helioguard 365

Stability of MAAs in Helioguard 365

Inhibitory Effect of Helioguard 365 on DNA Damage caused by UV Irradiation in Human Fibroblast Cells

Improvement of Skin Firmness, Smoothness, and Wrinkles by Helioguard 365

Inhibitory Effect of Helioguard 365 on Lipid Peroxidation

Enhancement Effect of Helioguard 365 on SPF Value

HELINORI

About HELINORI

Properties and Activities of HELINORI

Stability of Helonori.

Suppression of Sunburn

Other Activities of Helonori

Biological Activities of MAAs and their Applications 2: Antioxidative Properties

ANTIOXIDATIVE ACTIVITIES OF MAAS

EFFECTS OF MAAS ON THE ANTIOXIDANT SYSTEM

Biological Activities of MAAs and their Applications 3: Anti-inflammatory Effects

EFFECTS OF MAAS ON UV-B-INDUCED INFLAMMATORY PATHWAY

Biological Activities of MAAs and their Applications 4: Anti-glycative Properties

ANTI-GLYCATIVE PROPERTIES OF MAAS

Biological Activities of MAAs and their Applications 5: Inhibition of Collagenase Activity

INHIBITORY EFFECTS OF MAAS ON COLLAGENASE ACTIVITIES

Biological Activities of MAAs and their Applications 6: Metal Chelating Abilities

POTENTIAL METAL CHELATING ACTIVITIES OF MAAS

Biological Activities of MAAs and their Applications 7: DNA Protective Property, Wound Healing Effects, Anti-Cancer Effects, And Applications in Horticulture and as a Film Material

DNA Protective Properties of MAAS

WOUND HEALING EFFECTS OF MAAS.

ANTI-CANCER EFFECTS OF MAAS

APPLICATION OF MAAS TO HORTICULTURE

APPLICATION OF MAAS AS FILM MATERIALS

Appendix A

Appendix B

Appendix C

Appendix D

Appendix E

Subject Index

Back Cover.

Notes:

Includes bibliographical references and index.

Description based on publisher supplied metadata and other sources.

Description based on print version record.

ISBN:

9789815136081

9815136089

OCLC:

1379432629