Intensity Modulated Radiation Therapy : A Clinical Overview / Indra J. Das [and three others].

Format:

Book

Author/Creator:

Das, Indra J., author.

Contributor:

Institute of Physics (Great Britain), publisher.

Series:

IPEN-opleidingsreeks.

IPEM-IOP Series in Physics and Engineering in Medicine and Biology Series

Language:

English

Subjects (All):

Radiotherapy.

Radiotherapy, Intensity-Modulated.

Radiation Oncology.

Medical Subjects:

Radiotherapy, Intensity-Modulated.

Radiation Oncology.

Physical Description:

1 online resource (various pagings) : illustrations (some color).

Edition:

First edition.

Place of Publication:

Bristol [England] (Temple Circus, Temple Way, Bristol BS1 6HG, UK) : IOP Publishing, [2020]

System Details:

Mode of access: World Wide Web.

System requirements: Adobe Acrobat Reader, EPUB reader, or Kindle reader.

Biography/History:

Indra J Das is currently Vice Chair, Professor and Director of Medical Physics at Northwestern University Feinberg School of Medicine in Chicago. He is serving or served on several journal editorial boards including, International Journal of Radiation Oncology, Biology, Physics, Medical Physics, British Journal of Radiology, and Journal of Radiation Research. Nicholas J Sanfilippo is a radiation oncologist with special interest in treatment of head and neck, thoracic, cutaneous, and genitourinary malignancies. He joined Weill Cornell Medicine in 2018 as Vice Chairman of the Department of Radiation Oncology, Residency Program Director, and Director of Quality Assurance. Antonella Fogliata is a research scientist at the Humanitas Research Hospital in Milan-Rozzano. She teaches many courses covering radiotherapy advanced technologies for medical physicists and clinicians. She serves as associate editor on a number of journals, including Physica Medica. Luca Cozzi was the head of the physics unit at the Oncology Institute of Southern Switzerland and a research scientist at the Humanitas Research Hospital. He has acted also as a Privat Docent at the University of Lausanne, Adjunct Professor at the Humanitas University, and president of the Swiss Society of Radiobiology and Medical Physics.

Summary:

Intensity modulated radiation therapy (IMRT) has become standard of care for most cancer sites that are managed by radiation therapy. This book documents the evolution of this technology over 35 years to the current level of volumetric arc modulated therapy (VMAT). It covers every aspect of this radiation treatment technology, including the fundamentals of IMRT/VMAT, basic principles and advanced processes for implementation. The physics of IMRT is followed by the clinical application in major disease sites such as central nervous system, head and neck, breast, lung, prostate and cervix. It also provides updated references on each component of IMRT/VMAT. This book is written by leading experts in the field with extensive clinical experience in the practice and implementation of this technology. Part of IPEM-IOP Series in Physics and Engineering in Medicine and Biology.

Contents:

1. Introduction

2. Beam modulation

2.1. Forward planning

2.2. Paradigm shift

2.3. Simulated annealing

3. Definitions and terminology

3.1. Pixel

3.2. Voxel

3.3. Bixel (beamlet)

3.4. Intensity level

3.5. Segment

3.6. Concept of dose painting

4. IMRT devices

4.1. Intensity modulation filter/compensator

4.2. Dynamic Jaw

4.3. MLC based

4.4. Direct aperture optimization (DAO)

4.5. Systems for IMRT

5. IMRT, IMAT and VMAT

5.1. IMRT

5.2. IMAT

5.3. Volumetric, modulated arc therapy, VMAT

5.4. Outlook

6. Intensity modulated planning process

6.1. IMRT planning process

6.2. Imaging

6.3. Target volume

6.4. DVH constraints

6.5. Inverse planning

6.6. MLC sequencing

6.7. Transfer and treatment sequencing

6.8. Phantom plan

6.9. IMRT PSQA

6.10. Treatment verification

6.11. Record and verification

7. Contouring

7.1. Contouring for intensity modulation inverse planning

7.2. Margins

7.3. Motion and contouring

7.4. Auto-segmentation

8. Treatment planning

8.1. Beam (and arc) geometry

8.2. The collimator rotation

8.3. Non-coplanarity

8.4. Flattened and unflattened beams

8.5. Modulation degrees and delivery accuracy

8.6. The feathering : large field splitting and multi-isocentric setup

8.7. Artifact handling

8.8. The interplay effect

8.9. The neutron production and the whole body dose : beam quality

8.10. Conclusions on treatment planning

9. Optimization

9.1. The inverse planning concept

9.2. The goals and the cost function

9.3. The optimization objectives

9.4. The optimization algorithms

9.5. The direct aperture optimization

9.6. The biological optimization

9.7. Benefit and deficiencies in biological optimization

9.8. Robust optimization

10. Dose calculation

10.1. Required accuracy in dose calculation

10.2. Dose calculation algorithms and classification

10.3. Type 'a', 'b', 'c' algorithm classification

10.4. Dose-to-medium or dose-to-water?

10.5. Dose calculation accuracy in various TPS implementations

10.6. Fluence to dose and MLC parameters : another source of uncertainty

10.7. The out-of-field dose

10.8. Dose calculation with metallic objects

10.9. Other elements influencing the dose calculation accuracy

11. Plan variability

11.1. Dosimetric variation : the intra- and inter-planner and planning system sources

11.2. Knowledge-based planning

11.3. Protocol-based automation

11.4. Multi-criteria optimization

11.5. MCO, a posteriori

11.6. MCO, a priori

11.7. Plan variability conclusion

12. Quality assurance and verification

12.1. Theory of comparison

12.2. Silico method

12.3. Measurements

12.4. Log-file approach

12.5. Artificial intelligence

12.6. Outlook

13. IMRT dose prescription and recording

13.1. Planning variability

13.2. ICRU-83 guidelines

13.3. State of compliance

13.4. Essentiality in IMRT

14. Tumors of the central nervous system

14.1. Epidemiology

14.2. Anatomic considerations

14.3. Clinical and diagnostic evaluation

14.4. Intensity modulated radiation therapy : biologic considerations

14.5. Intensity modulated radiation therapy : technical considerations

14.6. IMRT for CNS tumors : general considerations

14.7. Clinical experience of IMRT in brain tumors

14.8. Clinical experience of IMRT in spinal and paraspinal tumors

14.9. IMRT for craniospinal irradiation

15. Head and neck cancer

15.1. Epidemiology

15.2. Anatomy

15.3. Nasopharyngeal carcinoma : general considerations

15.4. IMRT for nasopharyngeal carcinoma

15.5. Oropharyngeal carcinoma : general considerations

15.6. IMRT for oropharyngeal carcinoma

15.7. Carcinoma of the oral cavity : general considerations

15.8. IMRT for oral cavity carcinoma

15.9. Cancer of the larynx and hypopharynx : general considerations

16. Lung cancer

16.1. Epidemiology

16.2. Anatomy

16.3. Lung cancer : general considerations

16.4. IMRT for lung cancer

17. Breast cancer

17.1. Epidemiology

17.2. Anatomy

17.3. Breast cancer : general considerations

17.4. IMRT for breast cancer

18. Prostate cancer

18.1. Epidemiology

18.2. Anatomy

18.3. Prostate cancer : general considerations

18.4. Prostate cancer IMRT

19. Cervical cancer

19.1. Epidemiology

19.2. Cervical cancer : general considerations

19.3. IMRT for cervical cancer

20. Summary and outlook

20.1. Plan automation, adaptive therapy and artificial intelligence : a glance into the crystal ball

20.2. Decision-making artificial intelligence (AI) guided radiotherapy.

Notes:

"Version: 20201201"--Title page verso.

Includes bibliographical references.

Title from PDF title page (viewed on January 14, 2021).

Description based on print version record.

ISBN:

9780750313353

0750313358

OCLC:

1231597434