Biophysical and Chemical Properties of Collagen : Biomedical Applications / John A. M. Ramshaw and Veronica Glattauer.

Format:

Book

Author/Creator:

Ramshaw, John A. M., author.

Glattauer, Veronica, author.

Contributor:

Institute of Physics (Great Britain), publisher.

Series:

Biophysical techniques series (Menlo Park, Calif.)

Biophysical Society-IOP Series

Language:

English

Subjects (All):

Biomedical materials.

Physical Description:

1 online resource (various pagings) : illustrations (some color).

Edition:

First edition.

Place of Publication:

Bristol [England] (Temple Circus, Temple Way, Bristol BS1 6HG, UK) : IOP Publishing, [2020]

System Details:

Mode of access: World Wide Web.

System requirements: Adobe Acrobat Reader, EPUB reader, or Kindle reader.

Biography/History:

John Ramshaw is a chemist who studied at Van Mildert College, Durham University, UK, where he was awarded BSc, PhD and DSc degrees. He recently retired as a chief research scientist at CSIRO and is now at The University of Melbourne. He has extensive experience of collagen and biomedical materials, through research leading to papers and patents, consulting and innovation. Veronica Glattauer graduated from La Trobe University in Melbourne, Australia, with a BSc in chemistry and biochemistry. She was later awarded a PGDip in computer science from Monash University. She has extensive scientific knowledge in the area of biomaterial science and engineering, extracellular matrix biology (principally collagen), protein chemistry and cell biology.

Summary:

Collagen has proved to be a safe and effective biomedical material. Clinicians have used collagen-based devices in a wide range of applications with successful patient outcomes. This book gives an understanding of how present devices work, and could be improved, as well as the development of new devices where a knowledge of collagen structure, chemistry and biology is required. The purification of collagen materials and the fabrication of a range of collagen products and their applications are covered within. Current developments include recombinant collagen materials that provide further application opportunities. Written by experts in the field, this text will be of interest for researchers as well as lecturers and students. Part of Biophysical Society Series.

Contents:

15. Applications of biosynthetic materials

15.1. Vascular devices

15.2. Hernia, ligament and other options

16. Collagen applications in tissue engineering and regenerative medicine

16.1. Fabricated collagen as a supporting structure

16.2. ACM as a supporting structure

17. Coating of biomedical materials with collagen

17.1. Coating of synthetic polymers

17.2. Collagen on metals and inorganic materials

18. Composites of collagen with other materials

18.1. Composites with other biopolymers

18.2. Composites with synthetic polymers

18.3. Composites with inorganic materials

18.4. Composites with bioactive entities

part V. Conclusions. 19. Concluding remarks.

part I. Introduction. 1. Introduction

1.1. Overview

part II. The structure and biochemistry of collagen. 2. The structure of collagen

2.1. Composition

2.2. X-ray diffraction studies

2.3. Different collagen types

2.4. Other proteins with a triple-helix

2.5. Protein sequences

3. Biosynthesis and biodegradation of collagen

3.1. Biosynthetic pathway

3.2. Selected secondary modification enzymes in collagen biosynthesis

3.3. Degradation of collagen in tissues

4. Collagen assemblies

4.1. Ordered collagen structures

4.2. Fibrillogenesis

5. Tissue arrangement

5.1. Formation of new tissue

5.2. Native crosslinking

5.3. Examples of tissue structure

5.4. Mineralisation

5.5. Mechanical properties

6. Collagen stability

6.1. Molecular stability

6.2. Solvent effects on stability

6.3. Peptide models to study stability

6.4. Other uses for peptide models

7. Interactions

7.1. Describing interactions with other molecules

7.2. Interactions with other collagens

7.3. Interactions with proteoglycans

7.4. Interaction with globular proteins

7.5. Interactions with the immune system

7.6. Antibodies to collagens as biochemical reagents

part III. The production of collagen-based biomaterials. 8. Production of tissue-derived collagens

8.1. Tissue and fibrous collagen

8.2. Acellular matrix

8.3. Soluble collagens

8.4. Production of collagen in cell culture

8.5. Fractionation of soluble collagens

8.6. Further purification of soluble collagens

9. Production of recombinant collagens

9.1. Recombinant animal collagen production

9.2. Recombinant bacterial collagen production

9.3. Recombinant 'bioengineered' adaptations to collagen structures

9.4. Recombinant chimeric fusion proteins

9.5. De novo designed structures

10. Evaluation of the quality of collagen preparations

10.1. Collagen quantitation

10.2. Solution properties

10.3. Electrophoretic methods

10.4. Optical methods

10.5. Biophysical methods

11. Fabrication of biomedical products

11.1. Gels and hydrogels

11.2. Foams and sponges

11.3. Reconstituted fibres

11.4. Films and membranes

11.5. Beads and particles

11.6. Fibrous capsule materials

11.7. Other technologies

11.8. Sterilisation

12. Chemical modifications

12.1. Chemical crosslinking methods

12.2. Physical crosslinking

12.3. Assessing the effectiveness of crosslinking

12.4. Site-specific chemical modifications

part IV. Applications of collagen in medical products. 13. Applications for intact tissue collagen

13.1. Stabilised tissues

13.2. Acellular matrix

14. Applications for purified collagen

14.1. Gels and hydrogels

14.2. Foams and sponges

14.3. Films and membranes

14.4. Beads and particles

14.5. Reconstituted fibres

Notes:

"Version: 20191101"--Title page verso.

Includes bibliographical references.

Title from PDF title page (viewed on December 9, 2019).

Description based on print version record.

ISBN:

9780750320955

0750320958

9780750320962

0750320966

OCLC:

1130295065