Updated Recommendations on Treatment of Adolescents and Children with Chronic HCV Infection, and HCV Simplified Service Delivery and HCV Diagnostics.

Format:

Book

Author/Creator:

World Health Organization, author, issuing body.

Language:

English

Subjects (All):

Child health services.

Physical Description:

1 online resource (155 pages)

Edition:

1st ed.

Place of Publication:

Geneva : World Health Organization, 2022.

Summary:

This publication from the World Health Organization provides updated guidelines on the treatment of adolescents and children with chronic Hepatitis C Virus (HCV) infection. It details the simplified service delivery models for HCV testing, care, and treatment, emphasizing a public health approach. The guidelines aim to enhance understanding of HCV epidemiology, natural history, and the effectiveness of direct-acting antivirals. It also addresses task-sharing and improving the uptake of testing and linkage to care. Intended for healthcare professionals and policymakers, the document includes methodologies, evidence summaries, and recommendations for integrating HCV services globally. Generated by AI.

Contents:

Intro

ACKNOWLEDGEMENTS

ABBREVIATIONS AND ACRONYMS

GLOSSARY OF TERMS

EXECUTIVE SUMMARY

chapter 1. INTRODUCTION

1.1 Objectives and scope of updated HCV guidelines

1.2 Related guidelines

1.3 Intended audience

1.4 Guiding principles

chapter 2. BACKGROUND - EPIDEMIOLOGY AND NATURAL HISTORY

2.1 Epidemiology of hepatitis C virus infection and the challenge of HCV elimination

2.2 Natural history of HCV infection

2.3 Routes of transmission

2.4 Direct-acting antivirals

chapter 3. METHODOLOGY AND PROCESS OF DEVELOPING THE GUIDELINES

3.2 WHO guideline development process (Web Annex 1)

3.3 Roles

3.4 Evidence that informed the recommendations

3.5 Grading of certainty of evidence and strength of recommendations

3.6 Formulation of recommendations

3.7 Declarations of interest and management of conflicts of interest

3.8 Dissemination and updating of the guidelines

TREATMENT IN ADULTS, ADOLESCENTS AND CHILDREN

CHAPTER 4. TREATMENT FOR ADULTS, ADOLESCENTS AND CHILDREN (≥3 YEARS)

4.1 New recommendations: Treatment of adolescents (12-17 years), older children (6-11 years) and younger children (3-5 years) and Existing 2018 recommendations for adults

4.2 Background

4.3 Summary of the evidence for treatment in adolscents and children (Web Annex 4A)

4.4 Rationale for the recommendations

4.5 Implementation considerations

4.6 Research gaps

SIMPLIFIED SERVICE DELIVERY FOR A PUBLIC HEALTH APPROACH TO HCV TESTING, CARE AND TREATMENT

CHAPTER 5. DECENTRALIZATION AND INTEGRATION

5.1 Recommendations: Decentralized and integrated HCV testing and treatment services

5.2 Background

5.3 Summary of evidence (Web Annex 5A)

5.4 Rationale for recommendation

5.5 Implementation considerations

5.6 Research gaps

CHAPTER 6. TASK SHARING

6.1 Recommendation: task sharing.

6.2 Background

6.3 Summary of the evidence (Web Annex 5A)

6.4 Rationale for the recommendations

6.5 Implementation considerations

6.6 Existing additional good practice principles for simplified service delivery (from 2018 HCV treatment guidelines)

CHAPTER 7. IMPROVING THE UPTAKE OF TESTING AND LINKAGE TO CARE

7.1 Summary of existing and new recommendations on improving uptake of testing and linkage to care

7.2 Background

7.3 Summary of the evidence for three 2017 recommendations to promote testing and linkage

7.4 Rationale for the 2017 recommendations for three strategies to promote testing and linkage

7.5 Implementation considerations

HCV DIAGNOSTICS

CHAPTER 8. DETECTION OF VIRAEMIC HCV INFECTION TO GUIDE TREATMENT - New recommendations

8.1 Existing and new recommendations on detection of HCV viraemic infection

8.2 Background

8.3 Summary of evidence - POC HCV RNA NAT assays

8.4 Rationale for the recommendations - POC HCV RNA NAT assays

8.5 Summary of the evidence - laboratory-based HCV RNA NAT assays from 2017 hepatitis testing guidelines (4)

8.6 Rationale for the recommendations - lab-based HCV RNA assays

8.7 Implementation considerations for POC HCV RNA and laboratory-based HCV RNA assays

8.8 Research gaps

CHAPTER 9. ASSESSMENT OF HCV TREATMENT RESPONSE - TEST OF CURE

9.1 Existing and new recommendations on assessment of HCV treatment response

9.2 Background

9.3 Summary of the evidence

9.4 Rationale for the recommendations

9.5 Implementation considerations

9.6 Research gaps

CHAPTER 10. LABORATORY-BASED REFLEX TESTING AND REFLEX SAMPLE COLLECTION FOR HCV VIRAEMIA

10.1 New recommendation on reflex HCV RNA testing

10.2 Background

10.3 Summary of the evidence (Web Annex 10A1 and 10A2)

10.4 Rationale for the recommendations.

10.5 Implementation considerations

References.

Notes:

Description based on publisher supplied metadata and other sources.

Part of the metadata in this record was created by AI, based on the text of the resource.

OCLC:

1452606310