Provisional peer-reviewed toxicity values for the aliphatic low carbon range total petroleum hydrocarbon (TPH) fraction (various CASRNs) / Elizabeth O. Owens, Glenn E. Rice, and Allison L. Phillips.

Format:

Book

Author/Creator:

Owens, Elizabeth O., author.

Rice, Glenn E., author.

Phillips, Allison L., author.

Language:

English

Subjects (All):

Hydrocarbons.

Physical Description:

1 online resource

Other Title:

Provisional peer-reviewed toxicity values for the aliphatic low carbon range total petroleum hydrocarbon

Place of Publication:

Cincinnati, OH : U.S. Environmental Protection Agency, Office of Research and Development, Center for Public Health and Environmental Assessment, 2022.

Contents:

AUTHORS, CONTRIBUTORS, AND REVIEWERS

COMMONLY USED ABBREVIATIONS AND ACRONYMS

BACKGROUND

QUALITY ASSURANCE

DISCLAIMERS

QUESTIONS REGARDING PPRTVS

1. INTRODUCTION

1.1. DEFINITION OF THE ALIPHATIC LOW CARBON RANGE FRACTION

1.2. OVERVIEW OF PHYSICOCHEMICAL PROPERTIES AND ENVIRONMENTAL FATE

1.3. OVERVIEW OF MIXTURE ASSESSMENT METHODS

2. SUMMARY OF TOXICITY AND DOSE-RESPONSE ASSESSMENT APPROACH

2.1. IDENTIFICATION OF RELEVANT MIXTURES AND COMPOUNDS WITH TOXICITY VALUES

2.2. IDENTIFICATION OF OTHER RELEVANT TOXICITY DATA

2.3. METHODS FOR INDICATOR CHEMICAL SELECTION

2.4. DEVELOPMENT OF EXPOSURE-RESPONSE ARRAYS

3. REVIEW OF POTENTIALLY RELEVANT DATA

3.1. NONCANCER EVIDENCE

3.2. CANCER EVIDENCE

4. TOXICOKINETIC CONSIDERATIONS

5. MECHANISTIC CONSIDERATIONS AND GENOTOXICITY

6. DERIVATION OF PROVISIONAL VALUES

6.1. DERIVATION OF ORAL REFERENCE DOSES

6.2. DERIVATION OF INHALATION REFERENCE CONCENTRATIONS

6.3. SUMMARY OF NONCANCER PROVISIONAL REFERENCE VALUES

6.4. CANCER WEIGHT-OF-EVIDENCE DESCRIPTOR

6.5. DERIVATION OF PROVISIONAL CANCER RISK ESTIMATES

APPENDIX A. LITERATURE SEARCH AND SCREENING

APPENDIX B. COMPOSITION OF MIXTURES RELEVANT TO THE ALIPHATIC LOW CARBON RANGE FRACTION

APPENDIX C. POTENTIALLY RELEVANT NONCANCER EVIDENCE

APPENDIX D. REFERENCES.

Notes:

Description based on publisher supplied metadata and other sources.