Bioactive Microbial Metabolites : Scope and Challenges / Vaibhav Mishra, Jitendra Mishra, and Naveen Kumar Arora, editors.

Format:

Book

Contributor:

Mishra, Vaibhav, editor.

Mishra, Jitendra, editor.

Arora, Naveen Kumar, editor.

Series:

Developments in applied microbiology and biotechnology.

Developments in Applied Microbiology and Biotechnology Series

Language:

English

Subjects (All):

Microbial metabolites--Health aspects.

Microbial metabolites.

Microbial metabolites--Biotechnology.

Physical Description:

1 online resource (368 pages)

Edition:

First edition.

Place of Publication:

London, England : Academic Press, [2024]

Summary:

This book, 'Bioactive Microbial Metabolites: Scope and Challenges,' edited by Vaibhav Mishra, Jitendra Mishra, and Naveen Kumar Arora, presents an in-depth exploration of microbial metabolites and their significant roles in various biological processes and applications. It covers topics such as the production and role of microbial secondary metabolites in biocontrol, the potential of microbial metabolites in biotechnology, and their applications in human health. The book is intended for researchers, practitioners, and students in microbiology and related fields, offering insights into recent advances and future perspectives in microbial metabolite research. It emphasizes the importance of microbial metabolites in environmental and health sciences, focusing on their potential therapeutic applications and biotechnological innovations. Generated by AI.

Contents:

Front Cover

Bioactive Microbial Metabolites

Copyright Page

Contents

List of contributors

1 Microbial secondary metabolites and their roles in biocontrol of phytopathogens

1.1 Introduction

1.2 Primary and secondary metabolites

1.3 Biological control agents

1.4 Fungal secondary metabolites

1.4.1 The genus Trichoderma

1.4.1.1 Biocontrol mechanism of Trichoderma

1.4.1.1.1 Mycoparasitism

1.4.1.1.2 Competition

1.4.1.1.3 Antibiosis

1.4.1.2 Plant growth promotion by Trichoderma

1.4.1.2.1 Induced systemic resistance

1.4.1.2.2 Plant root colonization

1.4.1.2.3 Symbiosis and endophytism

1.4.2 Actinomycetes

1.4.2.1 The genus Streptomyces as a biocontrol agent

1.5 Genus Bacillus for biological control of phytopathogens

1.5.1 Bacillus thuringiensis

1.6 Genus Pseudomonas for biological control of phytopathogens

1.6.1 2,4-Diacetyl phloroglucinol

1.6.2 Pyoluteorin

1.6.3 Hydrogen cyanide

1.6.3.1 Siderophores

1.7 Conclusion

Acknowledgment

Conflict of Interest

References

2 Microbial metabolites with biological control activity

2.1 Introduction

2.2 Lytic enzymes

2.3 Antibiotics

2.4 Endotoxins

2.5 Siderophores

2.6 Bacteriocins

2.7 Volatile organic compounds

2.8 Perspectives

2.9 Conclusion

3 Role of rhizobial metabolites in control of soil-borne phytopathogenic fungi

3.1 Introduction

3.2 Rhizobium-legume interactions and biological nitrogen fixation

3.3 Rhizobia as a biocontrol agent against fungal phytopathogens

3.4 Biocontrol mechanism of rhizobia

3.4.1 Antibiotics

3.4.2 Siderophores

3.4.3 Hydrogen cyanide

3.4.4 Hydrolytic enzymes

3.4.5 Induced systemic resistance

3.5 Future prospective and conclusion

Further reading

4 Agriculturally important microbial secondary metabolites.

4.1 Introduction

4.2 Metabolites from microbes

4.3 VOCs in microbe-microbe interaction

4.3.1 Bacteria-bacteria

4.3.2 Fungi-bacteria

4.3.3 Fungi-fungi

4.3.4 Biocontrol agents as efficient producers of VOCs and soluble metabolites

4.3.4.1 Bacillus

4.3.4.2 Pseudomonas

4.3.4.3 Trichoderma spp.

4.3.4.4 Beauveria bassiana

4.3.4.5 Metarhizium anisopliae

4.3.4.6 Verticillium lecanii

4.4 Bacterial metabolites with insecticidal properties

4.5 Conclusion

5 Microbial metabolites and bioactive compounds from fermented fruit waste

5.1 Introduction

5.2 Potential use of fruit waste

5.2.1 Biopolymers

5.2.2 Edible and essential oils

5.2.3 Phytochemicals

5.3 Fermentation of fruit waste stream

5.3.1 Production of methane and volatile fatty acids

5.3.2 Production of biosurfactant

5.3.3 Production of single-cell protein

5.3.4 Production of other compounds

5.4 Improvement of extractable bioactive compounds

5.5 Extraction of bioactive compounds

5.5.1 Solvent extraction

5.5.2 Supercritical fluid extraction

5.5.3 Ultrasound-assisted extraction

5.5.4 Microwave-assisted extraction

5.5.5 Pulse electric field-assisted extraction

5.6 Encapsulation of bioactive compounds

5.7 Conclusion

6 Fungal extracellular carboxylic acids associated with ore mining: a wide perspective for the future

6.1 Introduction

6.2 Citric acid

6.3 Itaconic acid

6.4 Fumaric acid

6.5 Malic acid

6.5.1 Oxidative tricarboxylic acid cycle

6.5.2 Reducing tricarboxylic acid cycle

6.5.3 Glyoxylate cycle

6.6 Gluconic acid

6.7 Lactic acid

6.8 Oxalic acid

6.9 Alpha-ketoglutaric acid

6.10 Filamentous fungi as bioleaching agents

6.11 Solubilization mechanisms in biohydrometallurgy.

6.12 Fungal organic acids in the hydrometallurgy of atmospheric leaching of laterites

6.13 Conclusion

7 Chitinase enzyme: sources and application

7.1 Introduction

7.2 Structure of chitinase

7.3 Sources of chitinase

7.3.1 Bacteria

7.3.2 Fungi

7.3.3 Plant chitinases

7.3.4 Insect chitinases

7.4 Chitinase production

7.4.1 Fermentation

7.4.2 Immobilization and recombinant methods

7.5 Applications of chitinases

7.5.1 Medical application

7.5.2 Biocontrol agents

7.5.3 Waste management

7.5.4 Production of single-cell protein

7.5.5 Novel food packaging

7.6 Conclusion

8 Microbial mannanases and their biotechnological applications

8.1 Introduction

8.2 Mannan degrading enzymes and their sources

8.3 Mode of action of mannanases

8.4 Microbial source of β-mannanase

8.4.1 Fungal β-mannanases

8.4.2 Bacterial β-mannanases

8.5 Biotechnological applications of β-mannanases

8.5.1 Functional food

8.5.2 Pharmaceutical sector

8.5.3 Coffee and fruit juice clarification

8.5.4 Paper and pulp

8.5.5 Feed sector

8.5.6 Detergent sector

8.5.7 Saccharification and biofuel generation

8.5.8 Oil drilling

8.5.9 Industrial stain or dye degradation

8.6 Conclusion

9 Kojic acid: history, properties, biosynthesis, and applications

9.1 History

9.2 Physico-chemical properties of kojic acid

9.3 Aspergillus as a producer of kojic acid

9.3.1 Biosynthetic pathway

9.3.2 Factors affecting kojic acid production

9.3.2.1 Medium constituents (C, N, and P sources)

9.3.2.2 Environmental conditions

9.3.2.3 Fermentation type

9.4 Derivatives of kojic acid

9.5 Applications of kojic acid

9.5.1 Antimicrobial agent

9.5.2 Anticancer agent

9.5.3 Tyrosinase inhibitor

9.5.4 Insecticides and pesticides.

9.5.5 Food industry

9.5.6 Chemical industry

9.6 Future directions and concluding remarks

10 Bioactive peptides derived from milk: formation and functional benefits

10.1 Introduction

10.2 Mechanisms for bioactive peptide formation

10.2.1 Enzymatic hydrolysis

10.2.2 Microbial fermentation

10.3 Functional effects of milk-derived bioactive peptides

10.3.1 Antihypertensive effect

10.3.2 Antioxidant effect

10.3.3 Anticancer effect

10.3.4 Anti type 1 diabetes effect

10.3.5 Opioid effect

10.3.6 Antimicrobial effect

10.3.7 Immunomodulatory effect

10.3.8 Role of COVID-19

10.3.9 Mineral-binding effect

10.4 Lactic acid bacteria (LAB) as source of bioactive peptides

10.5 Conclusion

11 Insights into the challenges and resolutions in the bacterial fermentation process

11.1 Introduction

11.2 Brief history of fermentation

11.3 Bacterial fermentation processes

11.3.1 Lactic acid fermentation

11.3.2 Ethanol fermentation

11.4 Challenges in bacterial fermentation processes

11.4.1 End product inhibition

11.4.2 High operational cost

11.4.3 Growth requirements of the production strain

11.4.4 Genetic characteristics of the production strain

11.4.5 Safety issues

11.5 Conclusions

12 Microbial protease: an update on sources, production methods, and applications

12.1 Introduction

12.2 Classification of protease

12.3 Source of microbial protease

12.3.1 Bacterial protease

12.3.2 Fungal proteases

12.4 Production of protease

12.5 Stability of protease

12.6 Application of microbial protease enzyme

12.6.1 Detergents industries

12.6.2 Dairy industry

12.6.3 Leather industry

12.6.4 Pharmaceutical industry

12.6.5 Food industry

12.6.6 Baking industry

12.7 Conclusion

References.

13 Microbial metabolites with anticancerous properties

13.1 Introduction

13.2 Algae metabolites

13.2.1 Carotenoids

13.2.1.1 Fucoxanthin

13.2.1.2 Fucoxanthinol

13.2.1.3 Astaxanthin

13.2.1.4 Zeaxanthin

13.2.1.5 Lutein

13.2.1.6 Violaxanthin

13.2.2 Cyanotoxins

13.2.3 Borophycin

13.2.4 Cucarin-A

13.2.5 Alkaloids

13.2.5.1 Calothrixin A and B

13.2.6 Polysaccharides

13.3 Bacterial metabolite

13.3.1 Actinomycetes

13.3.2 Streptomyces

13.4 Fungal metabolites

13.4.1 β-Glucan

13.4.1.1 5-Methylmellin

13.4.2 Xylaranic acid and monascin

13.4.3 Aromatic polyketides

13.5 Protozoal metabolites

13.6 Regulatory concerns

13.7 Conclusion

14 Underexplored groups of soil microorganisms: a treasure house for bioactive metabolites with therapeutic value

14.1 Introduction

14.2 Lineages of novel soil bacteria producing secondary metabolites

14.2.1 Acidobacteriota

14.2.2 Verrucomicrobia

14.2.3 Gemmatimonadota

14.2.4 Candidatus Rokubacteria

14.2.5 Chloroflexi

14.3 Biosynthetic gene clusters for secondary metabolites production by the soil microorganisms

14.4 Bioactive compounds from soil bacteria and their therapeutic value

14.4.1 Flavan-3-ols

14.4.2 Dehydroxymethylepoxyquinomicin

14.4.3 Calicheamicin

14.4.4 Allocyclinones

14.4.5 Kibdelomycin

14.4.6 Aminocoumarins

14.4.7 Svetamycins A-G

14.5 Underexplored soil fungi produce novel bioactive secondary metabolites

14.5.1 Psychrophilins A-H (1-8)

14.5.2 Solaninaphthoquione (1)

14.5.3 Geomycins A-C (160-162)

14.5.4 P-orlandin

14.5.5 Cyclosporin-A

14.5.6 Terretonin M (245) and N (1)

14.6 Conclusion

15 Use and applications of bioactive microbial metabolites in human health

15.1 Introduction

15.2 Microbial metabolites.

15.2.1 Primary metabolites.

Notes:

Includes bibliographical references and index.

Description based on publisher supplied metadata and other sources.

Part of the metadata in this record was created by AI, based on the text of the resource.

Description based on print version record.

ISBN:

9780443185694

0443185697