Advances in Antiviral Research / edited by Naveen Kumar, Yashpal Singh Malik, Shailly Tomar, Sayeh Ezzikouri.

Format:

Book

Author/Creator:

Kumar, Naveen.

Contributor:

Malik, Yashpal Singh.

Tomar, Shailly.

Ezzikouri, Sayeh.

Series:

Livestock Diseases and Management, 2662-4354

Language:

English

Subjects (All):

Virology.

Drugs--Design.

Drugs.

Bioinformatics.

Structure-Based Drug Design.

Local Subjects:

Virology.

Structure-Based Drug Design.

Bioinformatics.

Physical Description:

1 online resource (463 pages)

Edition:

1st ed. 2024.

Place of Publication:

Singapore : Springer Nature Singapore : Imprint: Springer, 2024.

Summary:

This book illustrates advancements in the sophisticated tools and techniques for discovering and designing new antiviral drugs, identifying approved drugs against new and emerging viruses through large-scale computational virtual screening or drug repurposing approaches, and their evaluation in various in vitro and in vivo models. The chapters also cover the challenges associated with the emergence of antiviral drug resistance and possible ways to counter them. It discusses bioinformatics tools and software and computational approaches for the discovery of antivirals. The books also outline approaches for designing broad-spectrum antivirals effective against viruses by epigenetic- and epitranscriptomic-targeted reprogramming. Further, it provides vital details on the procedures for drug applications, clinical trials, and their regulations. Finally, the book provides a comprehensive yet representative description of advances in antiviral research protocols and methodologies suitable for antiviral researchers at all career stages, including graduate and postgraduate students and policy-makers.

Contents:

1. Antivirals: approaches and the way forward

2. Bioinformatics databases and tools available for the development of antiviral drugs

3. Developments in computer-aided drug design for antiviral research

4. Organoids in antiviral research: potential and challenges

5. Metabolomics tools in antiviral research

6. Epigenetic- and epitranscriptomic- targeted reprogramming: novel targets for the development of broad-spectrum antivirals

7. Application of cryoelectron microscopy in antiviral research

8. Host directed antiviral therapy

9. Role of herbal formulations in antiviral therapy - an overview

10. The use of animal models for antiviral therapeutics development: opportunities and challenges

11. In-vitro and in-vivo evaluation tools of SARS-CoV-2 antiviral drugs

12. Discovery of SARS-CoV-2 antiviral drugs through large-scale virtual screening of FDA-approved drugs

13. A high-throughput computational pipeline for selection of effective antibody therapeutics against viruses

14. Insights on various antiviral drugs for treating patients with COVID- 19

15. In ovo based antiviral assay for screening of herbal formulations against Influenza viruses

16. The path to cure Hepatitis B: How far are we?

17. Unveiling emerging avenues in antiviral research: navigating clinical trials and regulatory landscapes.

ISBN:

981-9991-95-1