Clinical Applications of Mass Spectrometry in Drug Analysis : Methods and Protocols / edited by Uttam Garg.

Format:

Book

Contributor:

Garg, Uttam., Editor.

Series:

Methods in Molecular Biology, 1940-6029 ; 2737

Language:

English

Subjects (All):

Mass spectrometry.

Pharmacology.

Analytical chemistry.

Drug abuse.

Criminology.

Mass Spectrometry.

Analytical Chemistry.

Drugs.

Local Subjects:

Mass Spectrometry.

Pharmacology.

Analytical Chemistry.

Drugs.

Physical Description:

1 online resource (XVI, 476 p. 80 illus., 51 illus. in color.)

Edition:

2nd ed. 2024.

Place of Publication:

New York, NY : Springer US : Imprint: Humana, 2024.

Summary:

This fully updated volume describes methods and protocols for a number of drugs and toxins in a stepwise manner. Exploring the versatility and flexibility of mass spectrometry, the book covers the advantages of this technology, which typically include elimination of the need for special reagents such as antibodies, increased sensitivity and specificity, and multi-component analysis enabling the screening of tens to hundreds of compounds in a single assay run. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, as well as tips on troubleshooting and avoiding known pitfalls. Authoritative and up-to-date, Clinical Applications of Mass Spectrometry in Drug Analysis: Methods and Protocols, Second Edition serves as a valuable resource for laboratory professionals who arealready utilizing mass spectrometry or considering bringing this technology to their labs.

Contents:

Mass Spectrometry in Clinical Laboratory: Applications in Therapeutic Drug Monitoring and Toxicology

Quantitative LC-MS/MS Analysis of Amphetamines and Cocaine in Human Urine

Quantification of Gabapentin, Lacosamide, Perampanel, Pregabalin, Rufinamide, and Vigabatrin in Serum Using Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)

Turbulent Flow Liquid Chromatography-Tandem Mass Spectrometry Methods for Antiepileptic Drug Quantitation in Serum

Quantitative LC-MS/MS Method for the Simultaneous Measurement of Six Antiepileptics and Pentobarbital in Human Serum

Triazole Antifungal Quantification for Therapeutic Drug Monitoring in Serum by Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS): Posaconazole, Voriconazole, Itraconazole, and Hydroxyitraconazole

Liquid Chromatography-Tandem Mass Spectrometry-Based Therapeutic Monitoring of Plasma Atovaquone Concentrations in Pediatric Patients

Analysis of Barbiturates in Urine by LC-MS/MS

High Throughput Quantitative LC-MS/MS Analysis of Barbiturates in Human Urine

High Throughput Quantitative LC-MS/MS Analysis of Benzodiazepines in Human Urine

Quantitation of Bupropion in Urine by Liquid Chromatography-Tandem Mass Spectrometry

Quantitative Analysis of Buprenorphine, Norbuprenorphine, and Their Glucuronide Metabolites in Human Urine

Liquid Chromatography-Tandem Mass Spectrometry Method for the Quantification of Plasma Busulfan

Determination of Busulfan and Melphalan in Plasma by Turbulent Flow Chromatography-Tandem Mass Spectrometry

Serum and Urine Quantification of Delta-8 and Delta-9 Tetrahydrocannabinol Carboxylic Acid Using Gas Chromatography-Mass Spectrometry

11-Nor-9-Carboxy-Δ8-Tetrahydrocannabinol, 7-Carboxy Cannabidiol, and 11-Nor-9-Carboxy-Δ9-Tetrahydrocannabinol in Urine by LC-MS/MS

Quantification of Clofarabine and Fludarabine in Plasma by High Performance Liquid Chromatography-Tandem Mass Spectrometry

Untargeted High-Resolution Mass Spectrometry for Detection of Natural Products and Confiscated Powders and Pills

Drug Screening of 49 Compounds by Liquid Chromatography-Tandem Mass Spectrometry in Saliva

High Throughput Comprehensive Quantitative LC-MS/MS Analysis of a Common Drugs and Metabolites (62 Compounds) in Human Urine

Detection of 41 Drugs and Metabolites in Urine with Internal Hydrolysis Control by Liquid Chromatography-Tandem Mass Spectrometry

Comprehensive Urine Drug Screen by Gas Chromatography-Mass Spectrometry (GC-MS)

Comprehensive Urine Drug Screen by Liquid Chromatography-Quadrupole Time of Flight Mass Spectrometry

A Liquid Chromatography-Tandem Mass Spectrometry Assay for Quantification of Ethyl Glucuronide and Ethyl Sulfate in Urine

Quantification of Fentanyl and Norfentanyl in Whole Blood Using Liquid Chromatography-Tandem Mass Spectrometry

Quantitative Assay of Fentanyl and Analogues Using LC-MS/MS

Analysis of Hypoglycemic Drugs by Liquid Chromatography-Tandem Mass Spectrometry

Multiplex Immunosuppressant (ISD) Method for the Measurement of Cyclosporine A, Tacrolimus, Sirolimus/Rapamycin, and Everolimus in Whole Blood Using MassTrakTM Kit

Assessment of Iohexol Serum Clearance by LC-MS/MS with Isotopically Labeled Internal Standard

Quantification of Mycophenolic Acid in Plasma by High Performance Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)

Quantitation of Urine Nicotine, Cotinine, and 3-OH-Cotinine by Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)

Quantification of Olanzapine by Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)

Quantitative Opiate, Opioid, and Benzodiazepine Testing by Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)

Quantitative LC-MS/MS Analysis of Opiates and Opioids in Human Urine

Quantification of Oxcarbazepine Using Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)

Liquid Chromatography-Tandem Mass Spectrometry for Quantitation of Serum Pentobarbital

Quantification of Phencyclidine (PCP) in Urine, Serum, or Plasma by Gas Chromatography-Mass Spectrometry (GC-MS)

Simultaneous Determination of Prednisone and Prednisolone in Serum by Turbulent Flow Liquid Chromatography-Tandem Mass Spectrometry

Measurement of ThioTEPA and Its Metabolite TEPA in Plasma and Cerebrospinal Fluid by Turbulent Flow Chromatography-Tandem Mass Spectrometry

A Direct Dilute and Shoot HPLC-MS/MS Method for Tetrahydrocannabinol (THC) Metabolites

Quantification of Thiopurine Metabolites in Human Erythrocytes by Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)

Determination of Treosulfan and Fludarabine in Plasma by Turbulent Flow Liquid Chromatography-Tandem Mass Spectrometry (TFLC-MS/MS)

Determination of Thiopurine S-Methyltransferase (TPMT) Activity in Human Erythrocytes by Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS).

ISBN:

9781071635414

1071635417