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Insulin signaling in primary adipocytes in insulin sensitive and insulin resistant states [electronic resource] / Siri Aili Fagerholm.
- Format:
- Book
- Author/Creator:
- Fagerholm, Siri Aili.
- Series:
- Linköping University medical dissertations ; 1369.
- Linköping University medical dissertations, 0345-0082 ; no. 1369
- Language:
- English
- Subjects (All):
- Insulin resistance.
- Physical Description:
- 64 p. : ill. (some col.).
- Edition:
- 1st ed.
- Place of Publication:
- Linköping, Sweden : Linköping University, 2013.
- Language Note:
- English
- Contents:
- Intro
- Supervisor
- Co-supervisor
- Faculty opponent
- Board committee
- Populärvetenskaplig sammanfattning
- List of original papers
- Abbreviations
- Introduction
- Adipose tissue and adipocytes
- Adipose tissue in glucose homeostasis and lipid metabolism
- Insulin signaling
- Caveolae, caveolin-1 and insulin signaling
- The insulin receptor
- The insulin signaling network
- Endocytosis of the insulin receptor
- Mechanisms of endocytosis and the endosomal network
- The insulin receptor substrate 1
- Phosphorylation of IRS1 at Ser307
- mTORC1 and mTORC2
- S6K1 and S6K2
- Insulin signaling in insulin resistant states
- Introduction to insulin resistance
- Type 2 diabetes and the metabolic syndrome
- Genetics and epigenetics
- Insulin signaling in subjects with type 2 diabetes
- Obesity and insulin resistance
- Hypertrophic obesity
- Hyperplastic obesity
- Obesity and systemic insulin resistance
- Adipose mass expansion and ectopic fat deposition
- Inflammation and insulin resistance
- Overfeeding and insulin resistance
- Mathematical modeling of biological systems
- Introduction to systems biology
- Formulation of a mathematical model
- Material and methods
- Summary of the papers
- Paper I
- Paper II
- Paper III
- Paper IV
- Future perspectives
- Acknowledgements
- References.
- Notes:
- Bibliographic Level Mode of Issuance: Monograph
- Includes bibliographical references.
- ISBN:
- 91-7519-577-1
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