Understanding the Dual Nature of Lysozyme : Part Villain - Part Hero: A Drosophila Melanogaster Model of Lysozyme Amyloidosis.
- Format:
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- Author/Creator:
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- Series:
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- Language:
- English
- Subjects (All):
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- Physical Description:
- 1 online resource (89 pages)
- Edition:
- 1st ed.
- Other Title:
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- Linköping Studies in Management and Economics. Dissertations
- Understanding the dual nature of lysozyme
- Place of Publication:
- Linköping : Linköping University Electronic Press, 2014.
- Summary:
- This dissertation by Linda Helmfors investigates the dual role of lysozyme, a protein found in bodily fluids, as both a protective agent and a contributor to disease. Using a Drosophila melanogaster model, the research explores lysozyme's involvement in amyloidosis and its potential impact on Alzheimer's disease (AD). The study highlights how lysozyme mutations lead to protein misfolding and aggregation, contributing to systemic amyloidosis. Additionally, the research examines the interaction between lysozyme and amyloid β peptide, revealing lysozyme's protective role against AD-related neurotoxicity. The work also studies the role of serum amyloid P component (SAP) in amyloid diseases, suggesting it may aid in correct protein folding. This dissertation is aimed at scientists and researchers in the fields of biochemistry, molecular biology, and neurology, offering insights into protein misfolding diseases and potential therapeutic approaches. Generated by AI.
- Contents:
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- Intro
- Abstract
- Populärvetenskaplig sammanfattning
- List of papers
- Contribution report
- Abbreviations
- Table of Contents
- Preface
- 1 Introduction
- 2 Aims of the research
- 3 Methodology
- 4 Results and discussion
- 5 Conclusions
- 6 Future work
- 7 Acknowledgements
- 8 References.
- Notes:
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- Description based on publisher supplied metadata and other sources.
- Part of the metadata in this record was created by AI, based on the text of the resource.
- ISBN:
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- OCLC:
- 927227420
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