Enzyme regulation in intermediary metabolism / Lloyd Wolfinbarger, Jr., Ph. D., professor emeritus, Old Dominion University, Norfolk, Virginia, USA.

Format:

Book

Author/Creator:

Wolfinbarger, Lloyd, Jr., author.

Language:

English

Subjects (All):

Enzymes--Regulation.

Enzymes.

Metabolism.

Physical Description:

1 online resource (190 pages) : illustrations (some color), graphs, tables

Edition:

1st ed.

Place of Publication:

Hoboken, New Jersey : Wiley Blackwell, 2017.

Summary:

Enzyme Regulation in Metabolic Pathways shows the reader how to understand the roles of enzymes and their kinetic constants in intermediary metabolism. It provides a means of correlating data obtained in experimental studies to multiple possible mechanisms through which some enzyme may catalyze the conversion of a substrate to a product. Although not the most appropriate means of determining some potential kinetic mechanism, quasi-equilibrium assumptions are used throughout the book, keeping the rate equation derivations simple. Actual metabolic pathways with known (presumed) positive and negative regulation events are linked to these potential kinetic mechanisms using both rate equation derivations and data plots illustrating how the rate equation derivations can be used to explain the data plots. This book will be a valuable reference for students in biological sciences and biochemistry majors required to take a core course in enzymology.

Contents:

Intro

Title Page

Copyright Page

Contents

Preface

Author's Review

Part I

Chapter 1 Characteristics of Enzymes

Thermodynamics

Enzyme Nomenclature

Activity Coefficients

Chapter 2 Self-Assembly of Polymers

Chapter 3 Beginnings of Equations

Secondary Data Plots

Chapter 4 Metabolite Distribution Systems

Chapter 5 Modification of Enzymatic Activity

Competitive Modifiers

Noncompetitive Modifiers

Uncompetitive Modifiers

Chapter 6 Modification of Metabolite Flow Through Metabolic Pathways

Chapter 7 Which is the Real Substrate?

Chapter 8 Non-Quasi-Equilibrium Assumptions

Chapter 9 Underlying Attributes of Assessing Enzymatic Activities

Primary Data Plots

Part II

Chapter 10 Breakdown of the Michaelis-Menten Equation (or Complex Enzyme Mechanisms)

Chapter 11 Rate Equation Derivation by the King-Altman Method: Two Substrates and Two Products

Assignment of Values to Kinetic Constants: Ordered Two-Substrate/Two-Product Mechanism

Chapter 12 Modification of Enzyme Mechanisms: The Next Generation

Role of the Binding Constants of Modifiers

Chapter 13 What Are These "Rate Constants" We Have Been Dealing With?

The Concentration Factor(s)

Bending the Data Curve Downward in Figure 13.2

Bending the Data Curve Upward in Figure 13.2

Other Factors Influencing Kinetic (Rate) Constants in Enzyme Mechanisms

Index

Supplemental Images

EULA.

Notes:

Includes bibliographical references and index.

Description based on print version record.

Includes index.

ISBN:

9781119155416

111915541X

9781119155409

1119155401

9781119155423

1119155428