Chemical warfare toxicology. Volume 1, Fundamental aspects / edited by Franz Worek, Bundeswehr Institute of Pharmacology and Toxicology, Munich, Germany, John Jenner, Defence Science and Technology Laboratory, Porton Down, UK, Horst Thiermann, Bundeswehr Institute of Pharmacology and Toxicology, Munich, Germany.

Format:

Book

Author/Creator:

Franz Worek

Contributor:

Worek, Franz, editor.

Jenner, John, editor.

Thiermann, Horst, editor.

Series:

Issues in toxicology ; 26.

Issues in toxicology ; 26

Language:

English

Subjects (All):

Chemical agents (Munitions)--Toxicology.

Chemical agents (Munitions).

Chemical warfare.

Poisoning.

Physical Description:

1 online resource (333 p.)

Place of Publication:

Cambridge : Royal Society of Chemistry, [2016]

Summary:

This book provides an up-to-date treatise on the on-going research into the toxicology of chemical warfare agents, the diagnosis and verification of exposure, and the pre- and post-exposure treatment of poisoning.

Contents:

Cover; Chemical Warfare Toxicology Volume 1: Fundamental Aspects; Preface; References to Material in the National Archives; Contents; Chapter 1 - Development, Historical Use and Properties of Chemical Warfare Agents; 1.1 Introduction; 1.2 Brief History of CW; 1.2.1 Prior to 1914; 1.2.2 The 1914-18 War (WWI); 1.2.2.1 Overview; 1.2.2.2 Irritants; 1.2.2.3 Chlorine; 1.2.2.4 Phosgene; 1.2.2.5 Sulfur Mustard; 1.2.2.6 Other Agents; 1.2.3 The Inter-War Years; 1.2.4 The 1939-1945 War (WWII); 1.2.5 Post WWII and the Cold War Years; 1.2.6 The Middle East; 1.2.7 Terrorism

1.2.8 Chemical Weapons Convention1.3 Classification, Properties and Modes of Use of CW Agents; 1.3.1 Classification; 1.3.2 Physicochemical Properties; 1.3.2.1 Gaseous and Liquid Agents; 1.3.2.2 Solid Agents; 1.3.3 Ease of Production; 1.4 Main Classes of Chemical Agents; 1.4.1 Lung Injurants (Choking Agents); 1.4.1.1 Chlorine; 1.4.1.2 Phosgene and Diphosgene; 1.4.1.3 Perfluoroisobutene; 1.4.2 Blood Agents; 1.4.2.1 Hydrogen Cyanide; 1.4.2.2 Cyanogen Chloride; 1.4.3 Vesicants (Blister Agents); 1.4.3.1 Sulfur Mustard; 1.4.3.2 Nitrogen Mustards; 1.4.3.3 Lewisite; 1.4.4 Nerve Agents

1.4.4.1 Tabun and DFP1.4.4.2 Sarin, Soman, Cyclosarin and 2-Methyl GF; 1.4.4.3 V Agents; 1.4.4.4 Other Nerve Agents; 1.4.5 Riot Control Agents; 1.4.6 Incapacitants; 1.4.7 Future Developments; References; Chapter 2 - Toxicology of Vesicants; 2.1 Introduction; 2.2 Sulfur Mustard; 2.2.1 Mechanism of Action; 2.2.1.1 Chemical Reactivity; 2.2.1.2 Alterations to DNA; 2.2.1.3 Alterations to Other Cellular Components and Processes; 2.2.2 Toxicokinetics, Metabolism and Distribution; 2.2.2.1 Studies in Animals

2.2.2.2.2 Other Routes of Exposure.No systematic studies describe the kinetics of SM following other routes of exposure in humans. In part...2.2.2.3 In vitro Studies; 2.2.3 Acute Toxicity; 2.2.3.1 Studies in Animals; 2.2.3.1.1 Oral Exposure.There are few reports on the oral toxicity of SM. In one study, the oral lethal dose, 50% (LD50) of SM [administer...; 2.2.3.1.2 Dermal Exposure.Since the first research efforts in 1917-1918, a large range of animal species have been exposed to SM liquid an...

Notes:

Description based upon print version of record.

Includes bibliographical references and index.

Description based on online resource; title from PDF title page (ebrary, viewed July 11, 2016).

ISBN:

9781523104765

1523104767

9781782622413

1782622411