Chemical warfare toxicology. Volume 2, Management of poisoning / edited by Franz Worek, Bundeswehr Institute of Pharmacology and Toxicology, Munich, Germany, John Jenner, Defence Science and Technology Laboratory, Porton Down, UK, Horst Thiermann, Bundeswehr Institute of Pharmacology and Toxicology, Munich, Germany.

Format:

Book

Author/Creator:

Franz Worek

Contributor:

Worek, Franz, editor.

Jenner, John, editor.

Thiermann, Horst, editor.

Series:

Issues in toxicology ; 27.

Issues in toxicology ; 27

Language:

English

Subjects (All):

Chemical agents (Munitions)--Toxicology.

Chemical agents (Munitions).

Chemical warfare.

Poisoning.

Physical Description:

1 online resource (346 p.)

Place of Publication:

Cambridge : Royal Society of Chemistry, [2016]

Summary:

This book provides an up-to-date treatise on the on-going research into the toxicology of chemical warfare agents, the diagnosis and verification of exposure, and the pre- and post-exposure treatment of poisoning.

Contents:

Cover; Chemical Warfare Toxicology Volume 2: Management of Poisoning; Preface; References to Material in The National Archives; Contents; Chapter 1 - Treatment of Nerve Agent Poisoning; 1.1 Introduction; 1.2 OP Compounds; 1.2.1 General Remarks That Are Relevant for Therapy; 1.2.2 Toxicology of OP Compounds; 1.2.2.1 Toxicokinetic Aspects Relevant for Therapy; 1.2.2.2 Toxicodynamics of Nerve Agents; 1.2.2.2.1 Reactions of Nerve Agents with AChE.OP compounds, i.e. nerve agents and pesticides, inhibit serine esterases such as AChE (E.C. ...

1.2.2.2.2 Binding of Nerve Agents to Other Targets.As highly reactive compounds, nerve agents are able to interact with a variety of prote...1.3 Protective Measures and Decontamination; 1.4 Clinical Picture of Nerve Agent Poisoning; 1.4.1 Acute Nerve Agent Poisoning; 1.4.1.1 Central Nervous System; 1.4.1.2 Autonomic Nervous System; 1.4.1.2.1 Sympathetic Nervous System.Nicotinic ACh receptors are located at paravertebral sympathetic ganglions. In response to the pregan...

1.4.1.2.2 Parasympathetic Nervous System.ACh is the primary neurotransmitter of the parasympathetic nervous system and neurotransmission o...1.4.1.3 Somatic Nervous System; 1.4.1.4 Conclusion; 1.4.2 Intermediate Syndrome; 1.4.3 Organophosphate Induced Delayed Neuropathy; 1.5 Pretreatment; 1.6 Differences Between Nerve Agent and OP Compound Pesticide Poisoning; 1.7 Therapeutic Regimen of Nerve Agent Poisoning; 1.7.1 General Considerations; 1.7.2 Atropine; 1.7.2.1 Self and Buddy Aid; 1.7.2.2 Treatment by Medical Specialists; 1.7.3 Oximes; 1.7.3.1 General Background

1.7.3.2 Effectiveness of Oximes in Nerve Agent Poisoning1.7.3.3 Interaction with Persisting Poison Load; 1.7.3.4 Oxime Dosing Strategies; 1.7.3.5 Monitoring of Oxime Therapy; 1.7.3.6 Obidoxime; 1.7.3.7 Pralidoxime; 1.7.3.8 HI-6; 1.7.3.9 Benzodiazepines; 1.7.3.10 Magnesium; 1.7.3.11 Alkalinization by Sodium Bicarbonate; 1.7.3.12 Supportive Treatment; 1.8 Summary and Outlook; References; Chapter 2 - Nerve Agents: Catalytic Scavengers as an Alternative Approach for Medical Countermeasures; 2.1 Introduction; 2.2 The Scavenger Concept; 2.3 Endogenous Bioscavengers; 2.4 Stoichiometric Scavengers

2.5 Pseudo-Catalytic Scavengers2.6 Catalytic Scavengers; 2.7 Requirements for Operational Catalytic Scavengers; 2.8 Potential Enzymes; 2.8.1 Phosphotriesterases; 2.8.1.1 Bacterial PTEs; 2.8.1.2 Human Paraoxonase; 2.8.1.3 Other Mammalian PTEs; 2.8.2 Engineered ChEs and CaEs; 2.8.3 Oxidases; 2.8.3.1 Glutathione S-Transferases; 2.8.3.2 Laccases; 2.9 Catalytic Antibodies; 2.10 Artificial Enzymes; 2.11 Future Directions; References; Chapter 3 - Nicotinic Receptors as Targets for Nerve Agent Therapy; 3.1 Introduction; 3.2 Current Therapy for Nerve Agent Poisoning

3.3 Potential Benefits of Nicotinic Antagonists in Nerve Agent Poisoning

Notes:

Description based upon print version of record.

Includes bibliographical references and index.

Description based on online resource; title from PDF title page (ebrary, viewed July 11, 2016).

ISBN:

9781523104772

1523104775

9781782628071

178262807X