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The Handbook of Medicinal Chemistry : Principles and Practice / edited by Simon E. Ward and Andrew M. Davis.
- Format:
- Book
- Author/Creator:
- Ward, Simon E, Editor.
- Language:
- English
- Subjects (All):
- Pharmaceutical chemistry--Handbooks, manuals, etc.
- Pharmaceutical chemistry.
- Drug development--Handbooks, manuals, etc.
- Drug development.
- Physical Description:
- 1 online resource : illustrations
- Edition:
- Second edition.
- Place of Publication:
- Royal Society of Chemistry 2023
- System Details:
- Mode of access: World Wide Web.
- Summary:
- Completely revised and updated, the 2nd edition of The Handbook of Medicinal Chemistry draws together contributions from authoritative practitioners to provide a comprehensive overview of the field as well as insight into the latest trends and research. An ideal companion for students in medicinal chemistry, drug discovery and drug development, while also communicating core principles, the book places the discipline within the context of the burgeoning platform of new modalities now available to drug discovery. The book also highlights the role chemistry has to play in wider target validation and translational technologies. This is a carefully curated compilation of writing from global experts using their broad experience of medicinal chemistry, project leadership and drug discovery and development from an industry, academic and charity perspective to provide unparalleled insight into the field.
- Contents:
- Title 1 Physicochemical Properties 2 Synthesis in Medicinal Chemistry 3 Useful Computational Chemistry Tools for Medicinal Chemistry 4 Structure-based Design for Medicinal Chemists 5 Fragment-based Ligand Discovery (FBLD) 6 Machine Learning in Drug Design 7 Drug Metabolism 8 ADME Optimization in Drug Discovery 9 Molecular Biology for Medicinal Chemists 10 Assays 11 In Vitro Biology: Measuring Pharmacological Activity that Will Translate to Clinical Efficacy 12 Animal Models: Practical Use and Considerations 13 Bioinformatics for Medicinal Chemistry 14 Translational Science 15 Discovery Toxicology in Lead Optimization 16 Toxicology and Drug Development 17 Patents for Medicines 18 Target Validation for Medicinal Chemists 19 Lead Generation 20 Lead Optimisation: What You Should Know! 21 Pharmaceutical Properties - The Importance of Solid Form Selection 22 The Medicinal Chemistry and Process Chemistry Interface 23 Clinical Drug Development 24 SMN2 Splicing Modification by Small Molecules - A Blueprint to Tackle the Underlying Genetic Cause of Many Underserved Diseases 25 The Discovery of Checkpoint Kinase 1 Inhibitors: From Fragments to Clinical Candidate 26 Medicinal Chemistry for Neglected Diseases - Malaria, Tuberculosis, Sleeping Sickness, Leishmaniasis and River Blindness 27 New Therapeutic Chemical Modalities: Compositions, Modes-of-action, and Drug Discovery Subject Index
- Notes:
- Includes bibliographical references and index.
- Description based on online resource; title from digital title page (viewed on April 16, 2023)
- Description based on print version record.
- Description based on online resource; title from PDF title page (EBook Central, viewed April 15, 2025).
- ISBN:
- 1-83767-107-9
- 1-83916-588-X
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