Biomaterial Based Approaches to Study the Tumour Microenvironment / edited by Jessica O. Winter and Shreyas Rao.

Format:

Book

Author/Creator:

Jessica O Winter

Contributor:

Winter, Jessica O., editor.

Rao, Shreyas, editor.

Series:

Biomaterials science series ; Number 14.

Biomaterials Science Series ; Number 14

Language:

English

Subjects (All):

Tumors.

Biomedical materials.

Physical Description:

1 online resource (487 pages)

Edition:

First edition.

Place of Publication:

London, England : Royal Society of Chemistry, [2023]

Summary:

This book provides an introduction to the rich chemical, topographical, and mechanical cues in the tumour microenvironment and then introduces readers to bioengineering strategies.

Contents:

Cover

Contents

Preface

Chapter 1 Tissue Engineering Models for Cancer Pathology

1.1 Introduction

1.2 Historical Timeline

1.3 Content Organization

1.4 Conclusions and Future Outlook

Acknowledgements

References

Chapter 2 Introduction to the Tumor Microenvironment

2.1 Cancer

2.2 The Tumor Microenvironment

2.3 The Tumor and its Microenvironment - Principles

2.4 The Phenotype of TME-residing Cells (Cancer andNon-cancerous Cells Alike) is Shaped by Reciprocal Cues

2.4.1 Cell to Cell Signaling

2.4.2 Acellular Signaling

2.5 Target Cancer-TME Interactions for Cancer Therapy

Chapter 3 Mimicking Fibrous Topographical Features of the Tumor Microenvironment

3.1 The Fibrous Extracellular Matrix in Tumors

3.2 Strategies to Mimic Fibrous ECM

3.3 Capturing the Interactions in the Tumor Microenvironment

3.3.1 Protrusions in Cancer Cells

3.3.2 Cancer Cell Migration

3.3.3 Forces Exerted by Cancer Cells

3.4 Concluding Remarks

Chapter 4 Mimicking Mechanical Features of the Tumor Microenvironment

4.1 Introduction to the Complex Nature of the Cancer Microenvironment

4.2 Impact of the Tumor MicroenvironmentalComponents or Constituents on Mechanics (Three Ways)

4.3 Microenvironmental Embedded Cells Impact Mechanics

4.3.1 Endothelial Cells Including Tumor Endothelial Cells and Pericytes

4.3.2 Cancer Associated Fibroblasts (CAFs)

4.3.3 Mast Cells in Tumors

4.3.4 Tumor Associated Macrophages (TAMs)

4.3.5 Immune Cells of the Innate and Adaptive Immune System

4.3.6 Cancer-associated Eosinophiles

4.3.7 Cancer-associated Neutrophiles

4.4 Dimensionality of Cell Culture Systems and Mechanics

4.5 How Can the Mechanics of Tumor Microenvironments be Mimicked?.

4.6 Effects of Native and Synthetic Microenvironments on Matrix and Cancer Cell Mechanics

4.6.1 Synthetic Matrices

4.6.2 Combined Native and Synthetic Matrices

4.6.3 Interpenetrating Networks

4.6.4 Microstructured Gels

4.7 Multicomponent Tumor Microenvironment Models

4.8 How do Mechanical Phenotypes of TumorMicroenvironments Contribute to Malignant Cancer Progression?

4.9 Conclusion and Outlook

Chapter 5 Mimicking Chemical Features of the Tumor Microenvironment

5.1 Introduction

5.2 Hallmarks of the Tumor Microenvironment

5.2.1 Components of the Tumor Microenvironment

5.3 Biomaterial Strategies to Mimic the Tumor Microenvironment

5.3.1 Natural Biomaterials

5.3.2 Synthetic Biomaterials

5.4 Recent Advances in Biomaterial Design for Cancer Research

5.5 Conclusion

Disclosure Statement

Abbreviations

Chapter 6 Mimicking Multicellular Features of the Tumor Microenvironment

6.1 Introduction

6.1.1 Basic Concepts for Modelling the Tumour Microenvironment

6.2 Deconstructing the Tumour Microenvironment

6.2.1 The Multicellular Composition of Tumour Tissues

6.2.2 The Extracellular Matrix of Healthy and Cancerous Tissues

6.2.3 The Biomechanical Profile of the Tumour Microenvironment

6.2.4 The Biochemical Profile of the Tumour Microenvironment

6.3 Tools to Engineer Multicellular Models of the Tumour Microenvironment

6.3.1 Mimicking the Extracellular Matrix

6.3.2 Recreating the Vascularisation of Tumour Tissues

6.3.3 Including the Metabolic and Inflammatory Profiles of Tumour Tissues

6.4 Perspectives for Multicellular 3D Models of the Tumour Microenvironment

Chapter 7 Cell Patterning to Mimic Tumor Anatomy

7.1 Introduction

7.2 Self-assembled Monolayers.

7.2.1 Self-assembled Monolayers for Culturing Cancer Cells

7.2.2 Self-assembled Monolayers for Investigating the Role of ECM Components in the TME

7.2.3 Microcontact Printing and Patterned 2D Surfaces

7.3 Self-assembled Spheroids

7.3.1 Spheroids Formed on Self-assembled Monolayers

7.3.2 Low-adhesion Plates

7.3.3 Hanging-drop Approaches

7.3.4 Microcapsules

7.3.5 Magnetic Levitation

7.4 Microlithography

7.4.1 Imprint/Molded Lithography

7.4.2 Imprint Lithography and Interactions with the ECM

7.5 Microfluidic Tumor Models

7.5.1 Cancer Cell Patterning in Microfluidic Devices

7.5.2 Microvessels in Microfluidic Tumor Models

7.6 Summary

Chapter 8 Advanced Scaffold Design via Electrospinning

8.1 Introduction

8.2 Electrospinning

8.2.1 Principle of Electrospinning

8.2.2 Materials for Electrospun Fibers

8.3 Structure of Electrospun Scaffolds

8.3.1 Random

8.3.2 Aligned

8.3.3 Multilayer

8.3.4 3D Structure

8.4 Immobilization of Tumor-related Agents Onto or Within Electrospun Fibers

8.4.1 Blend Electrospinning

8.4.2 Coaxial Electrospinning

8.4.3 Surface Functionalization

8.5 Electrospun Scaffolds for Tumor Applications

8.5.1 Properties of Electrospun Fibers to Mimic the Tumor Microenvironment

8.5.2 Cancer Biology

8.5.3 Cancer Detection

8.5.4 Therapeutic Applications

8.6 Conclusion and Outlook

Chapter 9 Advanced Scaffold Fabrication using Additive Manufacturing

9.1 Overview of Additive Manufacturing

9.2 Fabrication Methods for Printing Scaffolds to Mimic the Tumor Microenvironment

9.2.1 Stereolithography

9.2.2 Fused Deposition Modeling

9.2.3 Selective Laser Sintering

9.2.4 3D Printing

9.2.5 Bioprinting

9.3 Conclusion

References.

Chapter 10 Microfluidic Models of the Tumor Microenvironment

10.1 Introduction

10.2 Microfluidic Control of O2 Gradients

10.2.1 Physiological O2 Tension and Hypoxia

10.2.2 O2 Gradients

10.3 Microfluidic Control of Biomolecular Gradients

10.3.1 Oncogenic Gradients in the Tumor Microenvironment

10.3.2 Biomolecular Gradients

10.3.3 pH Gradients

10.4 Microfluidic Control of the Fluid Mechanical Environment

10.4.1 Interstitial Flow

10.4.2 Shear Stress and Intravascular Flow

10.5 Microfluidic Control of the Solid Mechanical Environment

10.5.1 Solid Stress and Tumor-vascular Interactions

10.5.2 ECM Composition and Microarchitecture of the Tumor Microenvironment

10.6 Conclusion and Future Perspectives

Chapter 11 Modeling of the Tumor Microenvironment in Tumor Organoids

11.1 Introduction

11.2 The Tumor Microenvironment and Organoid Models

11.3 Tumor Spheroids and Organoids

11.3.1 Tumor Spheroids

11.3.2 Tumor Organoids

11.4 Organoid Models of Individual Tumor Types

11.4.1 Breast Cancer

11.4.2 Colon Cancer

11.4.3 Liver Cancer

11.4.4 Gastric Cancer

11.4.5 Lung Cancer

11.4.6 Pancreatic Cancer

11.4.7 Other Cancers

11.4.8 Tumor-Immune Cell Organoid Models

11.5 Applications of Tumor Organoids

11.5.1 Drug Screening

11.5.2 Precision Medicine

11.5.3 Future Directions

11.6 Summary and Conclusions

Chapter 12 Imaging in Scaffolds

12.1 Challenges in Imaging Three-dimensional Tumor Microenvironment Scaffolds

12.2 Sample Processing to Facilitate Imaging

12.2.1 Tissue Clearing Methods

12.2.2 Imaging Contrast

12.3 Optical Coherence Tomography

12.3.1 OCT Instrumentation

12.3.2 OCT Applications for Imaging the Tumor Microenvironment

12.4 Confocal Microscopy.

12.4.1 LSCM Instrumentation

12.4.2 LSCM Applications for Imaging the Tumor Microenvironment

12.5 Light Sheet Microscopy

12.5.1 LSFM Instrumentation

12.5.2 LSFM For Imaging the Tumor Microenvironment and Tissue Scaffolds

12.6 Multiphoton Imaging

12.6.1 Multiphoton Instrumentation

12.6.2 Multiphoton Imaging for Imaging 3D Tumor Scaffolds

12.7 Magnetic Resonance Imaging

12.7.1 MRI Mechanism

12.7.2 MRI for Studies of the Tumor Microenvironment

12.7.3 MRI of Tissue Scaffolds for Imaging of 3D Tumor Microenvironments

12.7.4 Comparison of MRI and Optical Imaging

12.8 Quantitative Analysis of Images

12.8.1 Introduction

12.8.2 Basic Image Analysis Methods

12.8.3 Image Segmentation Methods

12.8.4 Cell Heterogeneity Analysis

12.9 Overall Summary

Chapter 13 The Intersection of Biomaterials, Tissue Engineering, and Immuno-oncology

13.1 Introduction

13.2 The Immune System and Cancer

13.2.1 Cell Types in the Tumor Immune Microenvironment (TIME)

13.2.2 Cancer Immunoediting and Immune Escape

13.3 Immunotherapies

13.4 3D Models in Immuno-oncology

13.4.1 Scaffold-free 3D Systems

13.4.2 Biomaterial-based Strategies for 3D Tumor and Immuno-oncology Engineering

13.5 Future Perspectives

Chapter 14 Tissue Engineered Models of Metastasis: Focus on Bone Metastasis

14.1 Introduction

14.2 Breast Cancer Bone Metastasis

14.2.1 Cellular Interactions Regulating the Bone Metastatic Cascade

14.2.2 Extracellular Matrix Properties Affecting Bone Metastasis

14.3 Tissue-engineered Models to Study Bone Metastasis

14.3.1 Biomaterials for Bone Metastasis Models

14.3.2 Current Advances of Tissue-engineered Bone Metastasis Models

14.4 Conclusions and Future Directions

Chapter 15 Tissue-engineered Cancer Models in Drug Screening.

Notes:

Description based on publisher supplied metadata and other sources.

Description based on print version record.

Includes bibliographical references and index.

Other Format:

Print version: Winter, Jessica O Biomaterial Based Approaches to Study the Tumour Microenvironment

ISBN:

1-83916-602-9

1-83916-601-0