Cyclic peptides : from bioorganic synthesis to applications / edited by Jesko Koehnke, James Naismith and Wilfred A. van der Donk.

Format:

Book

Contributor:

Koehnke, Jesko, editor.

Naismith, James, editor.

Donk, Wilfred A. van der, editor.

Series:

Chemical biology series.

Chemical Biology, 2055-1975

Language:

English

Subjects (All):

Cyclic peptides--Synthesis.

Cyclic peptides.

Physical Description:

1 online resource (379 pages) : illustrations (some color).

Place of Publication:

London, England : Royal Society of Chemistry, 2018.

Summary:

Cyclic peptides are increasingly employed as chemical tools in biology and drug discovery. They have gained a lot of interest as alternative sources of new drugs to traditional small molecules. This book introduces cyclic peptides and provides a thorough overview of biosynthetic and fully synthetic approaches to their preparation. Following an introduction to cyclic peptides, biosynthetic and traditional chemical routes to cyclic peptides are reviewed. Due to their size, their synthesis is not trivial. Recent advances in the incorporation of novel structural units are presented in addition to how synthesis and biological methods can be combined. The chemical analysis of this molecular class is also discussed. Furthermore, chapters detail the progression of cyclic peptides as tools in biology and as potential drugs, providing a future vision of their importance. In total, this book provides the reader with a comprehensive view of the state-of-the-art of cyclic peptides, from construction to possible clinical utility. This book will be an essential resource for students, researchers and scientists within industry in medicinal, bioorganic, natural product and analytical chemistry fields.

Contents:

An Introduction to Cyclic Peptides / Martin Empting

The Biosynthesis of Cyclic Peptides

RiPPs

an Overview / Clarissa M. Czekster and James H. Naismith

Thioesterase Domain-mediated Macrocyclization of Non-ribosomal Peptides / Sho Konno, Laëtitia Misson and Michael D. Burkart

The Biosynthetic Machinery and Its Potential to Deliver Unnatural Cyclic Peptides / Rashed S. Al Toma, Natalia A. Jungmann and Roderich D. Sussmuth

Modulation of Protein-Protein Interactions Using Cyclic Peptides / Salvador Guardiola, Sonia Ciudad, Laura Nevola and Ernest Giralt

Biology and Synthesis of the Argyrins / L. Millbrodt and M. Kalesse

Peptide Cross-links Catalyzed by Metalloenzymes in Natural Product Biosynthesis / Marcus I. Gibson, Clarissa C. Forneris and Mohammad R. Seyedsayamdost

Double-click Stapled Peptides for Inhibiting Protein-Protein Interactions / K. Sharma, D.L. Kunciw, W. Xu, M.M. Wiedmann, Y. Wu, H.F. Sore, W.R.J.D. Galloway, Y.H. Lau, L.S. Itzhaki and D.R. Spring

Libraries of Head-to-tail Peptides / Andrew T. Ball and Ali Tavassoli

An Introduction to Bacterial Lasso Peptides / Julian D. Hegemann and Mohamed A. Marahiel

Biological Synthesis and Affinity-based Selection of Small Macrocyclic Peptide Ligands / Toby Passioura, Yuki Goto, Takayuki Katoh and Hiroaki Suga

Mass Spectrometric Analysis of Cyclic Peptides / Yulin Qi and Dietrich A. Volmer

Experimental and Computational Approaches to the Study of Macrocycle Conformations in Solution / Joshua Schwochert and R. Scott Lokey

Trends in Cyclotide Research / Meng-Wei Kan and David J. Craik

Cyclic Peptides : A Look to the Future / Cristina N. Alexandru-Crivac, Luca Dalponte, Wael E. Houssen, Mohannad Idress, Marcel Jaspars, Kirstie A. Rickaby and Laurent Trembleau.

Notes:

Description based on online resource; title from PDF title page (ebrary, viewed January 29, 2018).

Includes bibliographical references at the end of each chapters and index.

ISBN:

9781788013772

1788013778

9781788010153

1788010159