The cellular response to the genotoxic insult : the question of threshold for genotoxic carcinogens / edited by Helmut Greim, Richard J. Albertini.

Format:

Book

Contributor:

Greim, Helmut.

Albertini, Richard J.

Series:

Issues in Toxicology

Issues in toxicology, 1757-7179 ; 13

Language:

English

Subjects (All):

Genetic toxicology.

Carcinogens.

Physical Description:

1 online resource (335 p.)

Place of Publication:

Cambridge [England] : RSC Pub., 2012.

Language Note:

English

Summary:

Genotoxic carcinogens can lead to DNA mutations with the potential to cause cancer. Typically, a series of mutation events are needed before malignancy occurs so a single, small exposure may not result in disease. Also, cells have an armoury of defence mechanisms which, to a degree, counter the effects of mutagens. Distinguishing the point at which exposure to a carcinogen increases mutation rates beyond the background level is challenging. In fact, there is now general agreement that, for genotoxic carcinogens, no specific threshold can be identified. However, NOAELs (No Observed Adverse Effe

Contents:

i-iv.pdf; v-vi; vii-xiv; 1-20; 21-32; 33-51; 52-62; 63-91; 92-112; 113-159; 160-179; 180-189; 190-212; 213-238; 239-265; 266-290; 291-311; 312-320

Notes:

Description based upon print version of record.

Includes bibliographical references and index.

ISBN:

1-84973-292-2

OCLC:

788646487