Guidance on pre-exposure oral prophylaxis (PrEP) for serodiscordant couples, men and transgender women who have sex with men at high risk of HIV : recommendations for use in the context of demonstration projects / World Health Organization.

Format:

Book

Author/Creator:

World Health Organization, author, issuing body.

Language:

English

Subjects (All):

HIV infections--Prevention.

HIV infections.

Physical Description:

1 online resource (16 pages)

Other Title:

Guidance on pre-exposure oral prophylaxis

Place of Publication:

Geneva : World Health Organization, 2012.

Summary:

These recommendations have been developed specifically to address the daily use of antiretrovirals in HIV-uninfected people to block the acquisition of HIV infection. This prevention approach is known as pre-exposure prophylaxis. At this stage evidence is available from studies with two groups: men and transgender women who have sex with men; and serodiscordant heterosexual couples. In parallel, WHO also is preparing new recommendations on the use of antiretroviral drugs in people living with HIV to prevent transmission of infection.

Contents:

1. BACKGROUND

1.1 Why is guidance needed?

2. OVERVIEW OF PREP RESEARCH

2.1 Clinical trials

2.2 Systematic review of evidence

3. RECOMMENDATIONS

3.1 Use of PrEP by serodiscordant couples

3.2 Use of PrEP by men and transgender women who have sex with men

3.3 Use of PrEP by other groups

4. NEED FOR DEMONSTRATION PROJECTS

5. REVIEW PROCESS

5.1 Monitoring the guidance

5.2 Declarations of conflicts of interests

REFERENCES

ANNEXES

Annex 1 Pre-exposure prophylaxis (PrEP) for HIV serodiscordant couples: a systematic review

Annex 2 GRADE Table for systematic review of serodiscordant couples

Annex 3 PrEP for serodiscordant couples: values and preferences review of the literature

Annex 4 Pre-exposure prophylaxis (PrEP) for men and transgender women who have sex with men (MSM and TG): a systematic review

Annex 5 GRADE table for systematic review of MSM/TG

Annex 6 PrEP for MSM/TG: values and Preferences review of the literature

Annex 7 Members of external groups.

Notes:

Description based on publisher supplied metadata and other sources.