Biologics for early rheumatoid arhritis / Hege Kornør, [and five others].

Format:

Book

Author/Creator:

Kornør, Hege, author.

Language:

English

Subjects (All):

Antirheumatic agents.

Biological products.

Physical Description:

1 online resource (97 pages)

Place of Publication:

Oslo, Norway : Norwegian Knowledge Centre for the Health Services, 2010.

Summary:

Rheumatoid arthritis (RA) is a chronic autoimmune disease that causes inflammation of the joints. The disease affects 0.5% to 1% of the adult population, and causes severe pain and disability. Direct costs related to treatment, and indirect costs associated with occupational disability, is significant. RA is treated with an interdisciplinary approach, in which disease modifying anti-rheumatic drugs (DMARDs) are an important component. The recommended first choice is one or more DMARDs. In the absence of treatment effect, a biologic drug may be added. The purpose of this systematic review was to investigate the efficacy and safety of biologics, compared with DMARDs in patients with early (d"3 years) RA. The commissioner is the Norwegian Rheumatism Association, whose members are concerned with good treatment at the early stages of RA. We included a total of 12 randomised controlled trials that examined the effect of biologics infliximab, adalimumab, etanercept and abatacept. The results suggest that, compared with DMARDs alone, biologicals in combination with DMARDs give:1. more patients in remission2. neither more or less serious adverse events3. more patients who achieved a 50% improvement4. improved physical function5. less joint destruction Due to methodological weaknesses in the included studies most results contain some degree of uncertainty.

Notes:

Description based on publisher supplied metadata and other sources.