Scleroderma : From Pathogenesis to Comprehensive Management / edited by Yannick Allanore, John Varga, Christopher P. Denton, Masataka Kuwana, Lorinda Chung, Ami A. Shah.

Format:

Book

Author/Creator:

Allanore, Yannick, author.

Language:

English

Subjects (All):

Rheumatology.

Local Subjects:

Rheumatology.

Physical Description:

1 online resource (XXI, 835 p.)

Edition:

3rd ed. 2024.

Place of Publication:

Cham : Springer International Publishing : Imprint: Springer, 2024.

Summary:

This fully-updated third edition of Scleroderma: From Pathogenesis to Comprehensive Management builds upon the well-regarded approach in the previous editions to provide integrated, concise, and up-to-date synthesis of current concepts of pathogenesis and modern approaches to management of systemic sclerosis (scleroderma). With a multidisciplinary approach to comprehensive care, this book is easily accessible for health care professionals in many fields. Comprised of the authoritative work of international experts, the new edition includes extensive updated material reflecting major developments in the field. It presents a succinct and thoughtful synthesis of current pathomechanistic concepts, providing a valuable reference tool for basic and translational investigators working in the field. Scleroderma: From Pathogenesis to Comprehensive Management serves as an essential, all-inclusive fully up to date resource for rheumatologists, pulmonologists, cardiologists, gastroenterologists, nephrologists and all those involved in the care of scleroderma patients.

Contents:

Preface

. Foreword

Section 1: Introduction.

1. Historical perspective of scleroderma

Section 2: Epidemiology, Genetics and Classification.

2. Epidemiology, Environmental and Infectious Risk Factors

3. Influence of ethnicity and sex bias in systemic sclerosis

4. Genetic Factors

5. Classification and Disease Subsets in Clinical Practice

6. Clustering and evolving concepts for subclassification

7. The Clinical Aspects of Autoantibodies

8. Systemic sclerosis overlap syndromes

9. Juvenile Localized and Systemic Scleroderma

10. Morphea (Localized scleroderma)

Section 3: The Biological Basis of Systemic Sclerosis.

11. Scleroderma Mimics

12. Introduction: The Etiopathogenesis of Systemic Sclerosis - an Integrated Overview

13. Pathology of Systemic Sclerosis

14. Inflammation And Immunity In Systemic Sclerosis

15. Autoantibodies as Markers and Possible Mediators of Scleroderma Pathogenesis

16. Mechanisms of Vascular Disease

17. Biomarkers in Systemic Sclerosis

18. Cellular and molecular mechanisms of fibrosis in systemic sclerosis

19. Overview of Animal Models

Section 4: Cardiovascular Manifestations and Management.

20. Overview of management and outcome assessment in systemic sclerosis

21. Raynaud’s Phenomenon, Digital Ulcers and Nailfold Capillaroscopy

22. Renal crisis and other renal manifestations

23. Cardiac Involvement: Evaluation And Management

Section 5: Pulmonary Manifestations and Management.

24. Overview of lung involvement

25. Clinical assessment of ILD

26. Lung Imaging Perspective in Scleroderma

27. Treatment of Interstitial Lung Disease in systemic sclerosis

28. Pathogenesis of Pulmonary Arterial Hypertension

29. Clinical Assessment of Pulmonary Hypertension

30. The management of pulmonary arterial hypertension in the setting of systemic sclerosis

Section 6: Gastrointestinal Manifestations and Management.

31. Overview of gastrointestinal tract involvement

32. UpperGastrointestinal Tract: Manifestations of Systemic Sclerosis

33. Lower Gastrointestinal Tract Involvement: Understanding the Interplay of Motility, the Microbiome and Nutrition

Section 7: Skin, Musculoskeletal and Other Complications.

34. Evaluation and Management of Skin Disease

35. Calcinosis

36. Tendons, Joints, and Bone

37. Skeletal Muscle Involvement

38. Cancer in Systemic Sclerosis

39. Overlooked Manifestations

40. Pregnancy

41. Vaccinations in Patients with Systemic Sclerosis

Section 8: Management and Outcome Assessment

42. Management Of Progressive Skin Involvement In Diffuse Scleroderma

43. Hematopoietic stem cell transplantation

44. Immune targeted therapies in SSc.

45. Physical and Occupational Therapy

46. Psychosocial Issues and Care for Patients with Systemic Sclerosis

Section 9: Case Studies: Approach to Complex Clinical Problems.

47. Measuring Disease Activity and Outcomes in Clinical Trials

48. Evolving clinical trial design andinnovative approaches

49. Drug Development and Regulatory Considerations for Systemic Sclerosis Therapies

50. Managing the Ischemic Finger in Scleroderma

51. Scleroderma Renal Crisis: a case study

52. Rapid diffuse skin disease with progressive joint contractures

53. Management of the Scleroderma Patient with Pulmonary Arterial Hypertension Failing Initial Therapy

54. Pseudo-obstruction with malabsorption and malnutrition

55. Progressive Interstitial Lung Disease Non-Responsive to Immunosuppressive Therapy

56. Body Image Distress in Scleroderma

57. Managing Complicated Digital Ulcers

58. Lower Limb Ulceration.

ISBN:

3-031-40658-3